DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mspo and spon-1

DIOPT Version :9

Sequence 1:	NP_001286427.1	Gene:	mspo / 36632	FlyBaseID:	FBgn0020269	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_495473.2	Gene:	spon-1 / 174169	WormBaseID:	WBGene00006893	Length:	819	Species:	Caenorhabditis elegans

Alignment Length:	688	Identity:	139/688 - (20%)
Similarity:	220/688 - (31%)	Gaps:	284/688 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 PATQPAPQTGCTLDRLAVYKVVLHTYWTRELFPKHYPDWRPTAQWTKTLGRTHNANYALYHIGQP 168
            |...|: .|.|..| :|.|.:.....|::...||.||.......:|..||.:|::||:|:.||..
Worm   183 PVDDPS-ATCCACD-IAQYDLEFTGIWSKNTHPKDYPTLEHLTHFTDMLGSSHSSNYSLWTIGGI 245

  Fly   169 ATAAVKQFAESGRTDLLDSNAGEQQQVQMQLQSQMQAGKSPSGGISSGTTSFNATAASTATPTGG 233
            :|..:|:.||.|.|...::.|..:..   :::|.|:.
Worm   246 STDGMKEIAEWGNTYKAEAEAKAKAS---EVRSLMKV---------------------------- 279

  Fly   234 SGGSGGSGGSGGTGTTTAERSVFDEFSMPAIPMGAGRSEAKVFVDSNHSLVSLMTRIVPSPDWFI 298
                               :.::       .|...|.::::..|:..|..|||.|...|||||.:
Worm   280 -------------------KGLW-------FPDVQGTTKSQFVVNKYHHFVSLATMFGPSPDWCV 318

  Fly   299 GVDSFELCVGG-SWIDTVTVELDPLDAGTDNGFTFTAPNWPTEPQGVIYRITSRYPGHPAGSFYY 362
            |:.|..||:.. :|.:..|.||.|.|||||:|.|:.:||.||||:..|:.||::.  :|...||.
Worm   319 GLSSVNLCLPDCTWAEERTFELQPFDAGTDSGPTYMSPNEPTEPREPIHWITTKL--NPLSPFYN 381

  Fly   363 PKSKRLPPIATFQFIKLKEYELSE-------------VFNIAED----DRKYETVQTQ------- 403
            .||..:|.:|.. .::.|....||             :.|.:||    ||: |.:.||
Worm   382 SKSDTIPTLAKV-ILRRKNVTSSECKSDDILKAEAHNITNTSEDEEYKDRR-ECMMTQWEPWSLC 444

  Fly   404 ---------------------------------THLDAEHNHVEMNNELSA-------------- 421
                                             ...:|:.|..|.:...|:
Worm   445 SATCGKGIRIRSRVYVFPIKAQVFHCHRQTTEKQFCNAKINECENSEAFSSKCQVSSWGSWGECS 509

  Fly   422 ------------------------SIERERQ------------------------TEQQQLQQND 438
                                    |::.||:                        ::......:.
Worm   510 VQCGHGMRSRNRTFLNPATKSGDCSVDLERKDICVGENGDDCNVTPDPLCKTTAWSDWSPCSASC 574

  Fly   439 DERQRIRSQLLAKMNPIYGSNNSLQPAPGQVVSVVPKNDKHAILQS----IASSYRRAADASDAN 499
            ||..|:|::|.     .|..:.              |...|..||.    :..|.||..:.:...
Worm   575 DEGVRVRTRLF-----FYSEHE--------------KRCMHVNLQEKDTCVMQSCRRFIEINSEE 620

  Fly   500 ASKPTPSAIGGGKAGGAVGGGAATRRRSSAQR--------------------------------- 531
            ..:....|   |:..|..........::..:|
Worm   621 ICQEDKQA---GQCAGNFPRYWYNHEKTQCERFIFTGCKGNRNQFETEEECKQICLPGYEKSKSL 682

  Fly   532 --------------------RRDCRVSHWSEWTACSKSCGVGEMHRYRKVIKHGKRGGRQCP--A 574
                                |.||.||.|:.|.:||.|||.|:..|.|.|:|..:.||.||.  .
Worm   683 IPNNQLLEDFGNTEVDDGGERVDCEVSKWTAWGSCSVSCGRGKKSRSRHVVKLARNGGHQCSEHL 747

  Fly   575 LQQ-------------------SKWCGTERNC-HGSQT 592
            :|:                   |:|.....:| .||||
Worm   748 MQELQCRLRPCPVKLTCQVGPWSRWSPCSVSCGEGSQT 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mspo	NP_001286427.1	Spond_N	120..363	CDD:283999	66/243 (27%)
mspo	NP_001286427.1	TSP1	537..588	CDD:214559	22/72 (31%)
spon-1	NP_495473.2	Reeler	36..171	CDD:260081
		Spond_N	197..381	CDD:283999	65/242 (27%)
		TSP1	435..481	CDD:214559	2/45 (4%)
		TSP1	499..551	CDD:214559	3/51 (6%)
		TSP1	562..610	CDD:214559	10/66 (15%)
		Kunitz_BPTI	621..672	CDD:278443	4/53 (8%)
		TSP1	708..759	CDD:214559	19/50 (38%)
		TSP1	766..816	CDD:214559	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3762
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850