Protein Alignment Targ and SLC16A4

DIOPT Version :10

• Sequence 1: NP_001286425.1
• Gene: Targ / 36630
• FlyBaseID: FBgn0033955
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_004687.1
• Gene: SLC16A4 / 9122
• HGNCID: 10925
• Length: 487
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 115/570 - (20%)
• Similarity: 211/570 - (37%)
• Gaps: 111/570 - (19%)

  Fly   300 DGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVL 364
            |||:||:|::..||..:.:.|:..|..:......::.:.:...:.::.|:.....|.:|...|::
Human    16 DGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFCAGPLVAII 80

  Fly   365 INRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYFER 429
            .:..|.:..:|.|........|.|||:.|:..|.....:|.   |:..:.::..:.::...||::
Human    81 CDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLLP---GLGSAFLYQVAAVVTTKYFKK 142

  Fly   430 YRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVGM- 493
            ...::...:.||.|...:|..| ..:|:.:..|..         .|||...:| :.:.|:.:.:
Human   143 RLALSTAIARSGMGLTFLLAPF-TKFLIDLYDWTG---------ALILFGAIA-LNLVPSSMLLR 196

  Fly   494 -YHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPKKKGCAKFCPSCSNCCWRRR 557
             .|:...:::...:...:...|.....:..|....:..||.:....:|.   ..||      :..
Human   197 PIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDSTTQKA---GLPS------KNL 252

  Fly   558 KKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNIR 622
            ..|||..|:              ||.||             .:..||:.||:.:.:|
Human   253 TVSQNQSEE--------------FYNGP-------------NRNRLLLKSDEESDKV-------- 282

  Fly   623 VDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLLKQFEFKILVASAFLFPMGF 687
                   ||       |         ||:         :|||..|.:...|.|...|..|..:.:
Human   283 -------IS-------W---------SCK---------QLFDISLFRNPFFYIFTWSFLLSQLAY 315

  Fly   688 NIPFVYSSARTT---IPVEYARMIGPIIGISNLVMRNILGILA-------YKRRSWTLGLCGCGL 742
            .||..:..||..   |.:..|..:..:.||...|.:.|.|.:|       |......|.|||...
Human   316 FIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQNWIKKYHYHKSYLILCGITN 380

  Fly   743 IFGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGM 807
            :...::..........:.:..|..|:...:.|.:....|.....::|||:         |...||
Human   381 LLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRNSTVNRFLGLA---------SFFAGM 436

  Fly   808 GAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGFLKLLLPLLIKCRNRM 857
            ....|..|||.|...|..|:.:|.|:|:|.::|......:||..:.:|.:
Human   437 AVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAERWKNSL 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Targ	NP_001286425.1	MFS_MCT_SLC16	304..842	CDD:340910	109/549 (20%)
SLC16A4	NP_004687.1	MFS_MCT5	20..481	CDD:340979	111/559 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..250		7/52 (13%)