DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12866 and ESBP6

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_014274.1	Gene:	ESBP6 / 855598	SGDID:	S000005069	Length:	673	Species:	Saccharomyces cerevisiae

Alignment Length:	393	Identity:	85/393 - (21%)
Similarity:	148/393 - (37%)	Gaps:	83/393 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EISKNQPAIPPSRPIE--------PISEVPFVEPAFEKKYSRTRGFSKELSTHRDNENEYIESTD 177
            |.|....:|..|:|:.        |:       |..:...:::...|::||..|...|.    .:
Yeast    18 ETSSEVSSINSSQPVSFSKASIAAPV-------PCSDLHSTKSNDASRKLSISRTLTNR----LN 71

  Fly   178 EVSQMLSFTSYTDEYDRAEPLITKTQKFYKKRSPLIPKYDSEDSY-VVPKETDQQESGLSFNVTT 241
            ::.:.:...:...|.:.|:     ..|..:.|      :|..|:. :...|:.|.:..:....||
Yeast    72 DIKKAVDDDNLQTEENSAD-----VNKILESR------FDVADAIRLQHNESVQSKLNIPVTHTT 125

  Fly   242 VQLADTASPES--FSEYD-GNRTRKQSFDMESK---NSKESFDFSRGGRRL-GSGM--------- 290
            ...|..::|.|  ||... .|.|.:....|:||   |..........|:.| ..|:
Yeast   126 TAGASLSAPSSSAFSASSIQNDTTEHKASMDSKLMRNRLYPASTKHSGKDLEAQGITEFEPDEPT 190

  Fly   291 ---VFI-----YMVIPPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLD------VSIS 341
               ||.     .:.:|||||:|||:....||......|...:.||   .:|..|:      .|..
Yeast   191 VKKVFTNKSTGQLELPPDGGYGWVVTFCVFLTMFSTWGCNASFGV---DLAYYLNHDTYPGASKY 252

  Fly   342 SVSFVASVQIGCYFTSGAFSAV---LINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSV 403
            ..:.:|.:.:   |.....|.:   |:...|.|...:.|......:.|.:|::..|..|   |..
Yeast   253 DYALIAGLTV---FLGQLLSPLVMALMRIIGLRTTMLFGDAVMLAAYLLASFTTKLWQL---YVT 311

  Fly   404 LACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLF---------TFLNS-WLVP 458
            .....|.::|:|:..:..::..:|.:.|.:|.|.|..|.|||.|::         .|.|: |.:.
Yeast   312 QGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGTGAGGVVYGLATNKMLSDFGNTRWCLR 376

  Fly   459 IIG 461
            |||
Yeast   377 IIG 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	39/173 (23%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392
ESBP6	NP_014274.1	MFS_MCT_SLC16	212..606	CDD:340910	42/177 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1250
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.050