DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12866 and SLC16A1

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001159968.1	Gene:	SLC16A1 / 6566	HGNCID:	10922	Length:	500	Species:	Homo sapiens

Alignment Length:	560	Identity:	111/560 - (19%)
Similarity:	203/560 - (36%)	Gaps:	154/560 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSA 362
            |||||:||.:::.:|::.........:|.|....|......:.|.||:::|:.:...:..|..|:
Human    13 PPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISS 77

  Fly   363 VLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
            :|:|::|.|.|.|.|...|...::|:|:..::..|   |..:...||:.|:.....:..::|.||
Human    78 ILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQL---YVCIGVIGGLGLAFNLNPALTMIGKYF 139

  Fly   428 ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVG 492
            .:.||:|||.:.:|....:.....||.....|.|||.......||::
Human   140 YKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLL------------------ 186

  Fly   493 MYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPKKKGCAKFCPSCSNCCWRRR 557
                                                                      |||
Human   187 ----------------------------------------------------------NCC---- 189

  Fly   558 KKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNIR 622
                   ....|:||          .||    || :|...|..:..|..:.|:      |:|...
Human   190 -------VAGALMRP----------IGP----KP-TKAGKDKSKASLEKAGKS------GVKKDL 226

  Fly   623 VDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLLKQFEFKILVASAFLFPMGF 687
            .|...|.|.|        :..|:|::      ...|:.:..|..|.....|.:.::...:...|.
Human   227 HDANTDLIGR--------HPKQEKRS------VFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGL 277

  Fly   688 NIPFV----------YSSARTTIPVEYARMIGPIIGISNLVMRNILGILAYKR--RSWTLGLCGC 740
            ..|.|          |||       |.:..:..|:...::|.|..:|::|..:  |.........
Human   278 FAPLVFLSSYGKSQHYSS-------EKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAA 335

  Fly   741 GLIFGGVSVL---ISAFYGENLIWFQFLYGFSYA-VAPAVYSTLRGLIYVKYLGLSKLTNAFGIT 801
            .::..||..:   :|..|....::..| :||::. ::..::.||..|:     |..:.::|.|:.
Human   336 SVVANGVCHMLAPLSTTYVGFCVYAGF-FGFAFGWLSSVLFETLMDLV-----GPQRFSSAVGLV 394

  Fly   802 SLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSG 841
            ::.......:|..:.|:|..:.|:|...:...|:.||:||
Human   395 TIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISG 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	42/175 (24%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	33/179 (18%)
SLC16A1	NP_001159968.1	2A0113	1..455	CDD:273325	111/560 (20%)
SLC16A1	NP_001159968.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..500
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145546
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850