DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12866 and si:dkey-246g23.4

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	XP_005169996.1	Gene:	si:dkey-246g23.4 / 559426	ZFINID:	ZDB-GENE-050419-234	Length:	457	Species:	Danio rerio

Alignment Length:	561	Identity:	126/561 - (22%)
Similarity:	204/561 - (36%)	Gaps:	153/561 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSA 362
            |.|||:||.|::.:||...:..|:|.:.||....|......:.::.|::.|:.:..........:
Zfish    14 PLDGGYGWFIVLSTFLVFGLTFGVIKSFGVFFVEIHHYFSTTATASSWITSISVATVHIGAPVGS 78

  Fly   363 VLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
            .|...||.|.|.:||.|.|:|.::..|::..|..|   |..:....|...::.|..:..::|:||
Zfish    79 ALSTYFGHRPVVMAGGLLSSVGMVLGSFAQDLLQL---YITVGFLTGFGYALTWTPTVTMLGWYF 140

  Fly   428 ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVG 492
            ::.||:||..|.:|.    .|.||:   |.|                ...|||
Zfish   141 DKRRPVANALSSTGE----CLLTFI---LTP----------------SFQLMV------------ 170

  Fly   493 MYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPKKKGCAKFCPSCSNCCWRRR 557
                        |::                                             .||..
Zfish   171 ------------DQF---------------------------------------------SWRGA 178

  Fly   558 KKSQNADEQNLLIRPA---PLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIK 619
            .....|.:.||.:..|   ||.|.|.|            |::::..|..|.....|
Zfish   179 MLILGALQLNLCVCGALLRPLSRHDYF------------KDSIEENEHELSKCSNN--------- 222

  Fly   620 NIRVDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLLKQFEFKILVASAFLFP 684
              |.|.:|.::..:    |:.:     .....|||||:       |.:     |.|..|..|..|
Zfish   223 --RADSDPMKVKVI----RYVD-----YTLIANSRFMV-------YSM-----FGIFAALGFFAP 264

  Fly   685 MGFNIPFVYSSARTTIPVEY-ARMIGPIIGISNLVMRNILGILAYKRRSWTL-GLCGCGLIFGGV 747
            ..|.:|:    ||:....|| |..:..|..:.:|:.|...|.:|..|...|: .|.|..::.|.|
Zfish   265 SLFLVPY----ARSQGVEEYQAASLMSISAVLDLLGRVFFGWVANLRLVETVHQLIGTVVLLGAV 325

  Fly   748 SVLIS-AFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFI 811
            .:|.. |.....|..|...||..:....|::.|    :..:.:|:.:|.:|.|...|....|..:
Zfish   326 LLLCPLATTFTQLAVFSAGYGLVFGATVAIHIT----VLAEVVGVERLGSALGFFMLIRSSGGLL 386

  Fly   812 GTTIAGKLIGITGNYSAAFCFAGLCLIVSGFLKLLLPLLIK 852
            |..:||..|....:|.|.|..||:.|:||....::|..:.|
Zfish   387 GPPLAGIFIDKMSDYGAGFLMAGVALLVSALFLIVLHFMNK 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	42/175 (24%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	46/166 (28%)
si:dkey-246g23.4	XP_005169996.1	2A0111	10..446	CDD:331689	126/561 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950