DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12866 and Mct1

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001284810.1	Gene:	Mct1 / 31198	FlyBaseID:	FBgn0023549	Length:	626	Species:	Drosophila melanogaster

Alignment Length:	642	Identity:	162/642 - (25%)
Similarity:	270/642 - (42%)	Gaps:	134/642 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSA 362
            |||||:|||::..||:..::.||:.::.|:.........:......:::||:.:|..|:||..|:
  Fly    28 PPDGGWGWVVVFGSFMIHIVTDGMTYSFGIFYNEFLDYFNEGKGYTAWIASIMVGVTFSSGPISS 92

  Fly   363 VLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
            ..:||:|.|.|.|||.:.:|..|:.|.::.::..||.   .:....|:...:|:..:.:.|..||
  Fly    93 SFVNRYGCRAVTIAGSILAASCIIVSMFAQNVLTLII---TIGFGTGLGFGLIYLPAIVSVTQYF 154

  Fly   428 ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAY--VEV-APT 489
            |..|.:|.|.:..|.|.|..:|..|..:|:...|||..:....|:::..::....:  :|: ||.
  Fly   155 EAKRSLATGIAVCGSGFGTFVFAPLTEFLIGNYGWRGAMLIIGGIVLNCIIFGAMFRPLELEAPP 219

  Fly   490 QVGMYHLPGSSDT-------------------------SSDEYYGNFYVHDYLRQSAMTA----- 524
            |..    |.:..|                         ..|:|.       .|.|...||
  Fly   220 QTP----PNTPSTPKLAKKSAIIDQNTTAAELEPLKVLPKDQYL-------QLPQRTDTAVSGGA 273

  Fly   525 --KSRSILSTYEPRPKK--------KGCAKFCP------SCSNCCWRRRKKSQNADEQNLLIRPA 573
              :|.|:....:|....        :|.....|      |.||....|:..||   .|...:|.|
  Fly   274 LCRSNSVGHNLKPNLNNNSNGAVNGQGPTLVTPPQAVVKSTSNDDIARKCHSQ---LQLTPLRDA 335

  Fly   574 PLERE--------DLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNIRVDDEPDRI 630
            ..||.        |..|.|        |..|:  .:::...:|.:......|:           |
  Fly   336 HRERSASGTMYRPDALYQG--------SLHNL--PDYVSSRNDLSRSMSGSGV-----------I 379

  Fly   631 SRVHRERRWSNENQKKQN-------SC-RNSRFMLTVLKLFDYRLLKQFEFKILVASAFLFPMGF 687
            .|....|:.:|.:|.::.       :| :.:|.  |..::.::.|||...|.|...|.|...:||
  Fly   380 KRYGSLRQSNNVSQSQEEAKCCGCITCSKETRD--TFAEMMNFSLLKDMVFVIFSVSNFCTSIGF 442

  Fly   688 NIPFVYSSARTTIPVEYARMIG----------PIIGISNLVMRNILGILAYK---RRSWTLGLC- 738
            |:|::|       .|.||..:.          ..||::|.|.|.|||.::.|   .|.....:|
  Fly   443 NVPYLY-------VVAYAETLKLTKTDASYLISTIGVANTVGRIILGYISDKPWVNRLLVYNVCL 500

  Fly   739 -GCGLIFGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITS 802
             .||:....|. |...|  ::|.::..::||:.    ..|..|..:|.|..|||.|||||||:..
  Fly   501 TACGVSTAMVP-LCHDF--QSLAFYCCVFGFTI----GAYVGLTSVILVDLLGLDKLTNAFGLLL 558

  Fly   803 LAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGFLKLLLPLLIKCRNRMAQ 859
            |..|:.:|||..|.|.:..:|.:|:.||..|||.:.:||.:...:|.|.:.:.|.::
  Fly   559 LFQGIASFIGPPIGGWMYDLTDSYAPAFLMAGLMIAISGLVMFAIPPLQRLQVRKSE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	44/177 (25%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	58/178 (33%)
Mct1	NP_001284810.1	MFS	35..>213	CDD:119392	46/180 (26%)
Mct1	NP_001284810.1	MFS	<426..604	CDD:119392	61/191 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449864
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1250
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900