DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12866 and Slc16a4

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001013935.1	Gene:	Slc16a4 / 295356	RGDID:	1359655	Length:	500	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	116/570 - (20%)
Similarity:	215/570 - (37%)	Gaps:	118/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSA 362
            |.|||:||::::..||..:.:.|:..|..:......::.:.:...:.::.|:.....|::|..:|
  Rat    14 PLDGGWGWMVVLHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIGWIGSIMSSLRFSAGPLAA 78

  Fly   363 VLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
            ::.:.||.:..:|.|....:...|.|||:..:..|.....:|.   |:..:.::..:.:::..||
  Rat    79 IICDIFGEKTTSILGTFLVSGGYLISSWATGIPFLCVTMGLLP---GLGSAFLYQVAAVVITKYF 140

  Fly   428 ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVG 492
            ::...::...:.||.|...:|..| ...|:.:..|..         .|||...:| :.:.|:.:.
  Rat   141 KKRLGLSTAIARSGMGLTFLLAPF-TKLLIDLYDWTG---------ALILFGAIA-LNLVPSSML 194

  Fly   493 MYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSR-SILSTYEPRPKKKGCAKFCPSCSNCCWRR 556
            :..:...||::||                  .|:: ||||...|....|      ....|
  Rat   195 LRPVHIQSDSNSD------------------IKNKGSILSATGPELSHK------TETPN----- 230

  Fly   557 RKKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNI 621
            |.|:|.:     ||:.:.:::.                           |....|..|
  Rat   231 RNKAQES-----LIKDSAVKKS---------------------------GQPTTTLTV------- 256

  Fly   622 RVDDEPDRIS-RVHRER--RWSNENQKKQN----SCRNSRFMLTVLKLFDYRLLKQFEFKILVAS 679
             ::::.:.|| |.||.|  ..||:...|:.    :|:.        ||.|..|.:...|.|...|
  Rat   257 -LENQIEEISTRPHRNRPLLMSNDKTYKKKFVSWNCKE--------KLLDISLFRNPFFYIFTWS 312

  Fly   680 AFLFPMGFNIPFVYSSARTT---IPVEYARMIGPIIGISNLVMRNILGILA-------YKRRSWT 734
            ..|..:.:.||..:..||..   |.:..|..:..:.||:..|.:.|.|.:|       |:.....
  Rat   313 FLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGITETVSQLISGWIADQNWIKKYQYHKAY 377

  Fly   735 LGLCGCGLIFGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFG 799
            |.|||...:...::..........:.:..|..|:...:.|.:....:.         |::....|
  Rat   378 LILCGVTNLLAPLATTFPLLMAYTIFFAIFAGGYLALILPVLVDLSKN---------SRVHRFLG 433

  Fly   800 ITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGFLKLLLPL 849
            ..|...||....|..|||.:...|..|..:|.|:|.|.|:|......:||
  Rat   434 YASFFAGMAVLSGPPIAGWIYDYTQTYVGSFYFSGTCYILSSVSLFFVPL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	32/175 (18%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	38/173 (22%)
Slc16a4	NP_001013935.1	MFS_MCT5	20..486	CDD:340979	112/564 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.850