Protein Alignment CG12866 and SLC16A8

DIOPT Version :9

• Sequence 1: NP_001286425.1
• Gene: CG12866 / 36630
• FlyBaseID: FBgn0033955
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_037488.2
• Gene: SLC16A8 / 23539
• HGNCID: 16270
• Length: 504
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 136/591 - (23%)
• Similarity: 215/591 - (36%)
• Gaps: 176/591 - (29%)

  Fly   282 GGRRLGSGMVFIYMVIPPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFV 346
            ||.|.|.|        |||||:|||::...|:......|....:.|...::.:|.|...|..::|
Human     4 GGPRRGEG--------PPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV 60

  Fly   347 ASVQIGCYFTSGAFSAVLINRFGFRKVAIA-GVLCSAVSILASSWSVSLTMLIFFYSVLACAGGI 410
            :|:.:...:.:|..|::|:.|||.|.|.:| |:|.||..||||    ..|.|:..|.......|:
Human    61 SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILAS----FATRLLELYLTAGVLTGL 121

  Fly   411 TLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIML 475
            .|::.:..|.:::|.||||.||:|||.:.:|....:...:.|...|:...|||      .|.::|
Human   122 GLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWR------GGFLLL 180

  Fly   476 --ILLMVVAYVEVAPTQVGMYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPK 538
              :||...|...|.....|    ||                                    |||
Human   181 GGLLLHCCACGAVMRPPPG----PG------------------------------------PRP- 204

  Fly   539 KKGCAKFCPSCSNCCWRRRKKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFL 603
                            ||......|.:       ||.|.|                  .||
Human   205 ----------------RRDSAGDRAGD-------APGEAE------------------ADG---- 224

  Fly   604 LMGSDKNTQQVNYGIKNIRVDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLFDYRLL 668
                           ..:::.:...|:    |.||                      :|.|..:.
Human   225 ---------------AGLQLREASPRV----RPRR----------------------RLLDLAVC 248

  Fly   669 KQFEFKILVASAFLFPMGFNIPFVYSSARTTIPVEYARMIG----------PIIGISNLVMRNIL 723
            ....|.:...:.||..:|..:|.:       :.|.||:..|          .|:|..::|.|...
Human   249 TDRAFAVYAVTKFLMALGLFVPAI-------LLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPAC 306

  Fly   724 GILA--YKRRSWTLGLCGCGLIFGGVSVLISA---FYGENLIWFQFLYGFSYAVAPAVYSTLRGL 783
            |.||  .:.|.....|....|:..|::.|.||   .||. |:.|...:|.||.:..|    |:..
Human   307 GALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGA-LVAFCVAFGLSYGMVGA----LQFE 366

  Fly   784 IYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSG-FLKLLL 847
            :.:..:|..:..:|.|:..|.......||...||:|:.:..||...|..||..:.::| |:.:..
Human   367 VLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVAT 431

  Fly   848 PLLIKC 853
            ...::|
Human   432 NCCLRC 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	52/178 (29%)
		MFS	675..>839	CDD:119392	45/178 (25%)
SLC16A8	NP_037488.2	2A0113	1..460	CDD:273325	136/591 (23%)
		MFS	19..429	CDD:119392	124/558 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..224		13/109 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..504

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950