DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12866 and mct-4

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001041267.1	Gene:	mct-4 / 180766	WormBaseID:	WBGene00003986	Length:	777	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	162/726 - (22%)
Similarity:	286/726 - (39%)	Gaps:	168/726 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 DGNRTRKQSF---DMESKNSKESFDFSRGGRRLGS---GMVFIY---------------MVIP-- 298
            |.||:.:.:.   .::|:.:.|| :|....:.:||   |.:..|               :::|
Worm     6 DPNRSSQPTSPTKSLKSERNGES-NFEEDDQDIGSLNDGQLTNYSSQYSINMGVQQVEPLLVPQA 69

  Fly   299 PDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAV 363
            ||||:||||:..:|::.|::||:.........|..:....|.....|:.|:.||.|...|...:.
Worm    70 PDGGYGWVIVFAAFMSNLVVDGISTAFSEFKQSYKERYQESDGLTVFIGSLIIGTYLLVGPLVSA 134

  Fly   364 LINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYFE 428
            |.|::..|.|.:||.|.|.::.:.:..|.::.:.:..|.|:   ||:...||:..:.::||:||:
Worm   135 LCNKYEQRYVVMAGGLISGIAFMIAPASPNIYVFMLIYGVM---GGLGFGMIYLPAIVVVGFYFD 196

  Fly   429 RYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYV--------- 484
            ..|.||.|.|.:|.|.|..|...:....:..:||:..:...|  :|:...:...|:
Worm   197 SKRAMATGISVAGSGVGTFLVPLICQVCIANLGWQKTIWVLA--VMIFSCVFYGYLYRPLPMVDL 259

  Fly   485 ------EVAPTQVGMYHL----------------------------------------------P 497
                  |:.|.:..:..:                                              .
Worm   260 NEIRDQEMEPLRQALSKVEDDEDEAVESPHPNRSTSAASGAIEDEAVSQNPEVQRLRSILTEGDE 324

  Fly   498 GSSDTSSDEYYGNFYVHDYLRQSAMTAK---------SRSILSTYEPRPKKKGCAKFCPSCSNCC 553
            ||....||.:....:.....|:..||:.         ||..||: :.|..:.....|..|.|
Worm   325 GSETPKSDAHKVRSHTATRSRKHTMTSNSGSQHDLKLSRGNLSS-DNRLSRVSARDFNQSLS--- 385

  Fly   554 WRRRKKSQNADEQNLLIRPA---------PLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDK 609
                |.|::....||.|..:         |:.|:|:||.|..:..|...:|..      :.|...
Worm   386 ----KLSKSGGASNLSIAMSGVDPKEFQRPMNRQDIFYGGSIQNLKEFKEEGT------MAGYRA 440

  Fly   610 NTQQVNYGIKNIRVDDEPDRISRVHRERRWSN-------ENQKK------QNSC--------RNS 653
            :|..:...:..       ..:|:::..|..|.       |::::      .:.|        ||:
Worm   441 STLSIPRSVVG-------QAVSQLNLSRTGSRLGGPGIAEDEEEMIEPFVDDGCCKVLPLPMRNA 498

  Fly   654 RFMLTVLKLFDYRLLKQFEFKILVASAFLFPMGFNIPFVY---SSARTTIPVEYARMIGPIIGIS 715
                 :.::.|..|||.....||..|..|..|||.||.::   .|....:.:..|..:.||.|:.
Worm   499 -----LSEMIDLNLLKNKTMMILCISNLLGMMGFYIPIMFLKDLSESMKLDMSLAMFLVPIFGVF 558

  Fly   716 NLVMRNILGILAYKRRSWTLGLCGCGLIFGGVSV----LISAFYGENLIWFQFLYGFSYAVAPAV 776
            |.:.|...|.|..::....|.:....||..|:..    |:::..|      |:.|...:....:.
Worm   559 NTIGRVFFGWLTDQKILSALTINNLSLIVSGLLTLACPLLTSIAG------QYFYAIVFGFIISA 617

  Fly   777 YSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSG 841
            |..|..::....:||..|||:||:..:|.|:.:.:|...||.:..|||:|..||.|.||.|:|:|
Worm   618 YICLTSIVLADLMGLENLTNSFGLLVVARGIASLVGPPFAGIVYDITGSYDTAFYFGGLVLLVAG 682

  Fly   842 FLKLLLPLLIK 852
            .:...:|.:.|
Worm   683 LISATIPFVTK 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	44/175 (25%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	50/170 (29%)
mct-4	NP_001041267.1	MFS_MCT_SLC16	75..>252	CDD:340910	49/181 (27%)
mct-4	NP_001041267.1	MFS_MCT_SLC16	<507..689	CDD:340910	55/187 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920