DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12866 and slc16a1a

DIOPT Version :9

Sequence 1:	NP_001286425.1	Gene:	CG12866 / 36630	FlyBaseID:	FBgn0033955	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001243569.1	Gene:	slc16a1a / 100534752	ZFINID:	ZDB-GENE-110408-16	Length:	461	Species:	Danio rerio

Alignment Length:	572	Identity:	108/572 - (18%)
Similarity:	203/572 - (35%)	Gaps:	165/572 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSA 362
            ||:||:||.:::.:|::.........:|.|....|....:.:.|.||:::|:.:...:..|..|:
Zfish    13 PPEGGWGWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSQVSWISSIMLAVMYGGGPVSS 77

  Fly   363 VLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
            :|:|::|.|.:.|.|...|...::|:|:..::..|.|...|:   ||:.|:.....:..::|.||
Zfish    78 ILVNKYGSRPIMILGGCLSGAGLIAASFCNTVEGLYFCVGVV---GGLGLAFNLNPALTMIGKYF 139

  Fly   428 ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVG 492
            .:.||:|||.:.:|....:.....||:|.....|||.......||::
Zfish   140 YKKRPIANGIAMAGSPVFLSTLAPLNTWFFDQFGWRGSFLILGGLLL------------------ 186

  Fly   493 MYHLPGSSDTSSDEYYGNFYVHDYLRQSAMTAKSRSILSTYEPRPKKKGCAKFCPSCSNCCWRRR 557
                                                                      |||
Zfish   187 ----------------------------------------------------------NCC---- 189

  Fly   558 KKSQNADEQNLLIRPAPLEREDLFYTGPAEYEKPHSKENVDGKEFLLMGSDKNTQQVNYGIKNIR 622
                   ....|:||          .||    ||......|.
Zfish   190 -------VAGSLMRP----------IGP----KPQPAVKADN----------------------- 210

  Fly   623 VDDEPDRISRVHRERRWSNENQKKQNSCRNSRFMLTVLKLF-DYRLLKQFEFKILVASAFLFPMG 686
                             ||...|::.:      ::.|:..| |..|.|...|.:.:....:...|
Zfish   211 -----------------SNSRAKERKT------VVEVINGFIDLTLFKHRGFLLYLLGNVVMFFG 252

  Fly   687 FNIPFVYSS--ART-TIPVEYARMIGPIIGISNLVMRNILGILAYKR--RSWTLGLCGCGLIFGG 746
            ...|.|:.|  |:: .||.|.|..:..|:...::|.|..:||:|..:  |..........::..|
Zfish   253 LFSPLVFLSNYAKSKQIPREKAAFLLSILAFVDMVARPSMGIVANTKWVRPRVQHFFAASILLNG 317

  Fly   747 VSVLISAFYGE--NLIWFQFLYGFSYA-VAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMG 808
            |..|::....:  ..:.:...:||::. ::..::.||..|:     |..:.::|.|:.::.....
Zfish   318 VCHLLAPLSTDYTGFVIYAIFFGFAFGWLSSVLFETLMDLV-----GAQRFSSAVGLVTIVECGP 377

  Fly   809 AFIGTTIAGKLIGITGNYSAAFCFAGLCLIV-SGFLKLLLPLLIKCRNRMAQ 859
            ..:|..:.||...|..:|...:...|:.|:: |.||.:.:.:..|...|.|:
Zfish   378 VLLGPPLLGKFNDIYHDYKYTYMGCGIVLLIGSLFLFVGMGINYKLLEREAK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12866	NP_001286425.1	MFS	308..>484	CDD:119392	42/175 (24%)
CG12866	NP_001286425.1	MFS	675..>839	CDD:119392	34/171 (20%)
slc16a1a	NP_001243569.1	2A0113	6..446	CDD:273325	108/572 (19%)
slc16a1a	NP_001243569.1	MFS	20..415	CDD:119392	100/549 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850