DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-E and ada2b

DIOPT Version :9

Sequence 1:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_687719.2	Gene:	ada2b / 559295	ZFINID:	ZDB-GENE-041210-77	Length:	501	Species:	Danio rerio

Alignment Length:	491	Identity:	178/491 - (36%)
Similarity:	288/491 - (58%)	Gaps:	26/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KSTPKDYRILREIFNSFERYSGVGNDIQLTLPERAANELIMCEKKREYEKGIMDPSKFAPGHHIF 110
            ||.|...:  ||.....|....:|.:::|...|:..:.|:...|.:|     :..|.|.|.:|.|
Zfish    25 KSMPDPRQ--REQMLQQELLQQIGGNMELNEAEKRMDSLLYMLKMKE-----ITLSPFPPANHFF 82

  Fly   111 QVLTKVKKSPLFQILRRMPKGAALKAHDTSMCSSRVVIEITYRDNLWVCTTQNGCRVEEFRFAKD 175
            :|...:::||:|::|::|||||||..|:::|.|...::..|||.|.::|.|.:|.  ..|.|:..
Zfish    83 KVRHIIQQSPIFKLLQKMPKGAALHIHNSAMVSVDWLLNATYRPNCYICFTWDGS--VRFMFSTS 145

  Fly   176 KP---KDVSFENGEWQPMEKLRELRG-----EENLRKYLQMRFSMYPLASFTTNAHAWRHMMGIF 232
            .|   ...||    |:.::.||...|     :.:|.:.|.: |:..|..|:.|..:.|:....||
Zfish   146 TPFPRWGCSF----WKRLDILRASLGDVTSFDNSLMRNLTL-FTEDPETSYPTQDYIWKRFEKIF 205

  Fly   233 GLLDGLLQYAPVWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRETVQIYKDTLERF 297
            ..|.||:.||||..|:.|..|||.|.|.:.|:|:|....:.|.|||:...:..|:::|::..|:|
Zfish   206 IALSGLITYAPVLKDHIYQGLKELYEDNIMYVELRIGQAKAYELDGTTHDRAWTIEVYRNITEQF 270

  Fly   298 KKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKEFPSFVVGFDLVGQEDVGHPLSNFAAEL 362
            :..||.||.:::|.:..|......|.:.::|..|:.:::|..|.||||||:||.|..:..| .:.
Zfish   271 RANHPDFIGTRVILSAHRSSSVSRVKQAVQEAIEMQRKYPEIVAGFDLVGREDTGGSIWYF-RDA 334

  Fly   363 LKLP--DHIHFYFHAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAKYLNIALEV 425
            |.||  ..:.::||||:|:..|:.||:|:|||::..|.|||||:.|..|||..:|::...:|:|:
Zfish   335 LSLPSESQLPYFFHAGETDLDGTDVDRNVLDALLFNTSRIGHGFAIVHHPVAKQLSRSRRVAVEL 399

  Fly   426 CPVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSPGFWRAAPLSHDFYMAFLGIAPMNADLKFL 490
            ||:|||||:|.||.|:||||.|:::..|||::|..|..:....||:|||..|:||..::|:|..|
Zfish   400 CPISNQVLKLVSDLRNHPAAVLMSDGHPMVVSSDDPSLFGTTGLSYDFYEVFVGIGGLSANLGTL 464

  Fly   491 KRTAKNSIKYSSLKDEAKAEAMEKWKKQWDKWV-EN 525
            |..|.|||:||||..:.:.:||..|:::|:.:: ||
Zfish   465 KELAINSIRYSSLSAQLQDKAMTVWQEKWNTFIAEN 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	21/78 (27%)
		adm_rel	52..527	CDD:273620	175/485 (36%)
		ADGF	105..519	CDD:238646	161/423 (38%)
ada2b	XP_687719.2	adm_rel	45..499	CDD:273620	170/466 (36%)
		A_deaminase_N	<46..97	CDD:285627	15/55 (27%)
		ADGF	77..493	CDD:238646	161/423 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595070
Domainoid	1	1.000	269	1.000	Domainoid score	I1799
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2141
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm6590
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.770