DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-E and ADA2

DIOPT Version :9

Sequence 1:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001269154.1	Gene:	ADA2 / 51816	HGNCID:	1839	Length:	511	Species:	Homo sapiens

Alignment Length:	478	Identity:	187/478 - (39%)
Similarity:	279/478 - (58%)	Gaps:	24/478 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ERYSGVGNDIQLTLPERAANELIMCEKKREYEKGIMDPSKFAPGHHIFQVLTKVKKSPLFQILRR 127
            |:...:|..:.|...|..|||.:|..|..|. |..|....|.|..|.||....:::|.:|.|||.
Human    41 EKMMRLGGRLVLNTKEELANERLMTLKIAEM-KEAMRTLIFPPSMHFFQAKHLIERSQVFNILRM 104

  Fly   128 MPKGAALKAHDTSMCS-SRVVIEITYRDNLWVCTTQNGCRVEEFRFAKDKPKDVSFENGEWQPME 191
            |||||||..||..:.: ..:|..:|||.:..:|.|..|  :.:||||...|:. |.:..:|..:|
Human   105 MPKGAALHLHDIGIVTMDWLVRNVTYRPHCHICFTPRG--IMQFRFAHPTPRP-SEKCSKWILLE 166

  Fly   192 KLRELRGEENLRKY---LQMRFSM---YPLASFTTNAHAWRHMMGIFGLLDGLLQYAPVWGDYYY 250
            ..|  :..:|:.::   |...|::   :|...:|.....|.....||..:.||:.||||:.||.:
Human   167 DYR--KRVQNVTEFDDSLLRNFTLVTQHPEVIYTNQNVVWSKFETIFFTISGLIHYAPVFRDYVF 229

  Fly   251 NALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRETVQIYKDTLERFKKEHPGFIDSKLIYAPIR 315
            .:::|||.|.|.|:|:|:.|..:|.|.|....:..:|:.|::..::|.:.||.||..|:||:..|
Human   230 RSMQEFYEDNVLYMEIRARLLPVYELSGEHHDEEWSVKTYQEVAQKFVETHPEFIGIKIIYSDHR 294

  Fly   316 HVQPELVGEYIKECTELNKEFPSFVVGFDLVGQEDVGHPLSNFAAELL-------KLPDHIHFYF 373
            .....::.|.|:....|..:||:.|.||||||.||.||.|.::...|:       |||    ::|
Human   295 SKDVAVIAESIRMAMGLRIKFPTVVAGFDLVGHEDTGHSLHDYKEALMIPAKDGVKLP----YFF 355

  Fly   374 HAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAKYLNIALEVCPVSNQVLQLGSD 438
            |||:|:|.|:.:|:|:|||::|.|.|||||:.::|||.:...:...:|.:||||:|||||:|.||
Human   356 HAGETDWQGTSIDRNILDALMLNTTRIGHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSD 420

  Fly   439 YRSHPAATLIAENVPMVIASGSPGFWRAAPLSHDFYMAFLGIAPMNADLKFLKRTAKNSIKYSSL 503
            .|:||.|||:|...||||:|..|..:.|..||:|||..|:||..|.|||:.||:.|.||||||:|
Human   421 LRNHPVATLMATGHPMVISSDDPAMFGAKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTL 485

  Fly   504 KDEAKAEAMEKWKKQWDKWVENI 526
            .:..|...||.|||:|||::.::
Human   486 LESEKNTFMEIWKKRWDKFIADV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	19/61 (31%)
		adm_rel	52..527	CDD:273620	187/478 (39%)
		ADGF	105..519	CDD:238646	171/427 (40%)
ADA2	NP_001269154.1	A_deaminase_N	12..102	CDD:285627	19/61 (31%)
		adm_rel	30..509	CDD:273620	187/478 (39%)
		Dimerization	30..100		18/59 (31%)
		ADGF	82..501	CDD:238646	171/427 (40%)
		PRB domain	127..185		17/62 (27%)
		Substrate binding	204..211		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159069
Domainoid	1	1.000	263	1.000	Domainoid score	I1937
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		otm41530
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.770