DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-E and ada

DIOPT Version :9

Sequence 1:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_031749914.1	Gene:	ada / 496434	XenbaseID:	XB-GENE-950501	Length:	365	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	79/318 - (24%)
Similarity:	127/318 - (39%)	Gaps:	49/318 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 AWRHMMGIFGLLDGLLQYAP-VWGD--------YYYNALKEFYADGVQYLEVR---------SVL 270
            :::..:.:...|.....|.| :.||        |.:..:|.  .:||.|:|||         .|.
Frog    57 SYKEPLSLTEFLSKFNHYMPAIAGDREAIKRIAYEFVEMKA--KEGVIYVEVRYSPHFLANSKVE 119

  Fly   271 PQLYSLDGSRMPKRETVQIYKDTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKE 335
            |..:......:...|.|.:....|.:.:|...  |.::.|...:||: |....|.::.|.:...:
Frog   120 PIPWGQKEGDITPDEVVDLVNQGLRKGEKAFN--IKARSILCCMRHM-PSWSTEVVELCKKYQND 181

  Fly   336 FPSFVVGFDLVGQEDV------GHPLSNFAAELLKLPDHIHFYFHAGQTNWYGSHVDQNLLDAIV 394
               .||..||.|.|.:      ||  .....|.:|.  .||...|||:..  .|.|.:..::  |
Frog   182 ---TVVAIDLAGDESLNCESYPGH--RKAYEEAVKC--GIHRTVHAGEVG--PSSVVKEAVE--V 235

  Fly   395 LGTKRIGHGYTITKHPVLMRLAKYLNIALEVCPVSNQVLQLGS---DYRSHPAATLIAENVPMVI 456
            |..:||||||..|:.|.|.:.....|:..||||.|:.:  .|:   |:..|||.....:.....:
Frog   236 LKAERIGHGYHTTEDPNLYKELLEKNMHFEVCPWSSYL--TGACHPDFTKHPATQFRKDKANYSL 298

  Fly   457 ASGSPGFWRAAPLSHDFYMAFLGIAPMNADLKFLKRTAKNSIKYSSLKDEAKAEAMEK 514
            .:..|..: .:.|..|:.:|   ...|....:..||...|:.|.|.|.:..|.|.:.|
Frog   299 NTDDPLIF-GSTLDVDYSIA---AKHMGFTEEEFKRVNINAAKSSFLPESEKKELLYK 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627
		adm_rel	52..527	CDD:273620	79/318 (25%)
		ADGF	105..519	CDD:238646	79/318 (25%)
ada	XP_031749914.1	ADA	17..353	CDD:238645	79/318 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R23
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940