DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-E and ada2a

DIOPT Version :9

Sequence 1:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001028889.2	Gene:	ada2a / 373884	ZFINID:	ZDB-GENE-030902-4	Length:	503	Species:	Danio rerio

Alignment Length:	508	Identity:	184/508 - (36%)
Similarity:	285/508 - (56%)	Gaps:	29/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 WIHHNPEKMTLLEMLGTTNLRKSTPKDYRILREIFNSFERYSGVGNDIQLTLPERAANELIMCEK 89
            ||:      .||....:.|.|....|     |:.....|.....|.||  ||.||   |.::..|
Zfish    11 WIY------LLLLCCASCNGRPDPRK-----RDALIGLEASRRTGGDI--TLNER---EKLLDGK 59

  Fly    90 KREYEKGIMDPSKFAPGHHIFQVLTKVKKSPLFQILRRMPKGAALKAHDTSMCS-SRVVIEITYR 153
            .::.::..|:..:|.|..|.|:....:.:||:|.::::|||||||..||.:|.| ..:|..:|||
Zfish    60 LQKLKQHDMEAGQFPPSMHFFKAKRLIDQSPVFNLIQKMPKGAALHVHDFAMVSVDWLVKNVTYR 124

  Fly   154 DNLWVCTTQNGCRVEEFRFAKDKPKDVSFENGEWQPMEKLRE-LRGEENLRKYLQMRFSMY---P 214
            :|.:||.|..  :..:|.|:...|.. |.....|..:..||| ::....|........:::   |
Zfish   125 ENCYVCFTDK--QTVQFIFSSGPPAS-SSHCSSWTLLRSLREKIKNTTELDNSFIRNLTLFTEDP 186

  Fly   215 LASFTTNAHAWRHMMGIFGLLDGLLQYAPVWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGS 279
            ..::......|.....:|.:..||:.||||:.||.|..|::||.|.:.|:|:|::|||.|.|||.
Zfish   187 DRAYPNQDTVWERFEQVFLVAYGLVTYAPVFKDYLYEGLRQFYEDNIMYVEIRALLPQTYELDGR 251

  Fly   280 RMPKRETVQIYKDTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKEFPSFVVGFD 344
            ...|..::...::.:.:|||.||.||.:::|:...|.:......:.::|...|.:.||..:.|||
Zfish   252 LNDKDWSMAACQEVVNQFKKHHPDFIGARVIFTVHRKINATEAVKTVEEAMILRRNFPDVMAGFD 316

  Fly   345 LVGQEDVGHPLSNFAAELLKLPD----HIHFYFHAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYT 405
            .|||||:|.||..| .:.|.||:    ::.::||||:|:..|:.|||||:||::..|.|||||:.
Zfish   317 FVGQEDLGRPLWYF-KDALSLPEDKGFNLPYFFHAGETDSQGTDVDQNLMDALLFNTTRIGHGFA 380

  Fly   406 ITKHPVLMRLAKYLNIALEVCPVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSPGFWRAAPLS 470
            :.:|||:..:|:.:.:.:||||:|||||:|.||.|.||||.|:||..|:||:|..|..:.|..||
Zfish   381 LARHPVVKEMARKMYVPIEVCPISNQVLKLVSDLRDHPAAVLMAEGHPLVISSDDPAVFGATALS 445

  Fly   471 HDFYMAFLGIAPMNADLKFLKRTAKNSIKYSSLKDEAKAEAMEKWKKQWDKWV 523
            ||||.||:|...|:.:|..||..|.||::||:|..:.|.||::....:|||:|
Zfish   446 HDFYEAFMGFGGMSFNLGTLKELALNSLRYSTLSSQRKEEAIDALLVKWDKFV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	20/78 (26%)
		adm_rel	52..527	CDD:273620	177/481 (37%)
		ADGF	105..519	CDD:238646	160/422 (38%)
ada2a	NP_001028889.2	A_deaminase_N	<29..95	CDD:285627	20/75 (27%)
		adm_rel	30..502	CDD:273620	178/483 (37%)
		ADGF	75..494	CDD:238646	160/422 (38%)
		Substrate binding. /evidence=ECO:0000250	197..204		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595069
Domainoid	1	1.000	269	1.000	Domainoid score	I1799
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2141
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm6590
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770