Protein Alignment Adgf-E and AMPD2

DIOPT Version :10

• Sequence 1: NP_610977.1
• Gene: Adgf-E / 36627
• FlyBaseID: FBgn0033952
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_004028.4
• Gene: AMPD2 / 271
• HGNCID: 469
• Length: 825
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 120/605 - (19%)
• Similarity: 197/605 - (32%)
• Gaps: 194/605 - (32%)

  Fly    19 TPTAAQWIHHNPEKMTLLEMLGTTNLRKST-PKD----YRILREIFNSFERYSGVGNDIQLTLPE 78
            ||.:|....|.|    .||.....:...|| |.|    .|::|.:.:.:.|.....:..::.||.
Human   235 TPVSADAPVHPP----ALEQHPYEHCEPSTMPGDLGLGLRMVRGVVHVYTRREPDEHCSEVELPY 295

  Fly    79 RAANELI-----------------MCEKKREYEKGIMDPSKFAPGHHIFQVLTKVKKSPLFQILR 126
            ....|.:                 .|.::.:|..     |||.  .|:              :|.
Human   296 PDLQEFVADVNVLMALIINGPIKSFCYRRLQYLS-----SKFQ--MHV--------------LLN 339

  Fly   127 RMPKGAALKAHDTSMCSSRVVIEITYRD--NLWVCTTQ---NGCRVEE--FRFAKDKPKD----- 179
            .|.:.||.|             ::.:||  |:....|.   :.|..::  .||.|...|.
Human   340 EMKELAAQK-------------KVPHRDFYNIRKVDTHIHASSCMNQKHLLRFIKRAMKRHLEEI 391

  Fly   180 VSFENGEWQPMEKLRELRGEENLRKYLQ-MRFSMYPLASFTTNAHAWRHMMGIFGLLDGLLQYAP 243
            |..|.|.            |:.||:..: |..:.|.|:..|.:.||.|:....|...:.  :|.|
Human   392 VHVEQGR------------EQTLREVFESMNLTAYDLSVDTLDVHADRNTFHRFDKFNA--KYNP 442

  Fly   244 ----------------VWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRE-TVQIYK 291
                            |.|.|:.:.:||..:|                |:.|:....| .:.||.
Human   443 IGESVLREIFIKTDNRVSGKYFAHIIKEVMSD----------------LEESKYQNAELRLSIYG 491

  Fly   292 ------DTLERFKKEH-------------PGFIDSKLIYAPIRHVQPELVGEYIK--ECT----- 330
                  |.|.|:...|             |...|.......:.:.|..|...::.  |.|
Human   492 RSRDEWDKLARWAVMHRVHSPNVRWLVQVPRLFDVYRTKGQLANFQEMLENIFLPLFEATVHPAS 556

  Fly   331 --ELNKEFPSFVVGFDLVGQE--------DVGHPLSNFAAELLKLPDHIHFYF------------ 373
              ||:. |...|.|||.|..|        ::..||.....|....|...:.|:
Human   557 HPELHL-FLEHVDGFDSVDDESKPENHVFNLESPLPEAWVEEDNPPYAYYLYYTFANMAMLNHLR 620

  Fly   374 ------------HAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAKYLNIALEVC 426
                        |.|:..     ...:|:.|.:| .:.|.||..:.|.|||..|.....|.:.:.
Human   621 RQRGFHTFVLRPHCGEAG-----PIHHLVSAFML-AENISHGLLLRKAPVLQYLYYLAQIGIAMS 679

  Fly   427 PVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSP--GFWRAAPLSHDFYMAFLGIAPMNADLKF 489
            |:||..|.|  .|..:|....::..:.:.:::..|  ..:...||..::.:|.......:.|:..
Human   680 PLSNNSLFL--SYHRNPLPEYLSRGLMVSLSTDDPLQFHFTKEPLMEEYSIATQVWKLSSCDMCE 742

  Fly   490 LKRTAKNSIKYSSLKDEAKA 509
            |   |:||:..|....:.|:
Human   743 L---ARNSVLMSGFSHKVKS 759

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	adm_rel	52..527	CDD:273620	109/567 (19%)
AMPD2	NP_004028.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49
		AMP_deaminase	163..806	CDD:437158	120/605 (20%)