Protein Alignment Adgf-E and Ampd3

DIOPT Version :10

• Sequence 1: NP_610977.1
• Gene: Adgf-E / 36627
• FlyBaseID: FBgn0033952
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001359370.1
• Gene: Ampd3 / 11717
• MGIID: 1096344
• Length: 775
• Species: Mus musculus
• Alignment Length: 670
• Identity: 134/670 - (20%)
• Similarity: 215/670 - (32%)
• Gaps: 238/670 - (35%)

  Fly     9 MLLAGWAR----RATPTAAQWIHHNPEKMTLLEMLGTTN-----------LRKSTPKDYRILREI 58
            |:...:||    |...|.||::.|..|.:.|.|.|...:           |..:.|....::|
Mouse   169 MIREKYARLAYHRFPRTTAQYLAHQGESVPLEEGLPDFHPPPLPQEDPYCLDDAPPNLGYLVR-- 231

  Fly    59 FNSFERYSGV--GNDIQLTLPERAANELIMCEKKREYEKGIMDPSKFAPGHHIFQVLTK------ 115
                 .:.||  ..|.|..|..:..:.|    ...:.|..|:|.|      ||..::|.
Mouse   232 -----MHGGVLFVYDNQTMLERQEPHSL----PYPDLETYIVDMS------HILALITDGPTKTY 281

  Fly   116 --------VKKSPLFQILRRMPKGAALKAH-----------DTSMCSSRVVIEITYRDNLWVCTT 161
                    ..|..|.::|..|.:...||::           ||.:.::             .|..
Mouse   282 CHRRLNFLESKFSLHEMLNEMSEFKELKSNPHRDFYNVRKVDTHIHAA-------------ACMN 333

  Fly   162 QNGCRVEEFRFAKDKPKDVSFENGEWQPMEKLRELRGEE-NLRK-YLQMRFSMYPLASFTTNAHA 224
            |.    ...||.|        ...:.:|...:.|..|.: .||: :..:....|.|...:.:.||
Mouse   334 QK----HLLRFIK--------HTYQTEPDRTVAEKLGRKITLRQVFDSLHMDPYDLTVDSLDVHA 386

  Fly   225 WRHMMGIFGLLDGLLQYAPV----------------WGDYYYNALKEFYAD----GVQYLEVRSV 269
            .|.....|...:.  :|.||                .|:|:...:||...:    ..||.|
Mouse   387 GRQTFHRFDKFNS--KYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEDSKYQYSE---- 445

  Fly   270 LPQLYSLDGSRMPK------RETVQ--IYKDTLE------------RFKKEHPGFIDSKL---IY 311
             |:| |:.| |.||      |..:|  :|...:.            |.||..|.|  .|:   |:
Mouse   446 -PRL-SIYG-RSPKEWSSLARWFIQHKVYSPNMRWIIQVPRIYDIFRSKKLLPNF--GKMLENIF 505

  Fly   312 API--RHVQPELVGEYIKECTELNKEFPSFVVGFDLVGQED--VGHPLSNFAAELLKLPD----- 367
            .|:  ..:.|:       :..||:. |..:|.|||.|..|.  ..|..|:.:..    ||
Mouse   506 LPLFKATINPQ-------DHRELHL-FLKYVTGFDSVDDESKHSDHMFSDKSPS----PDLWTSE 558

  Fly   368 ------HIHFYFHAG-------------QTNWYGSHVDQ-----NLLDAIVLGTKRIGHGYTITK 408
                  :..:|.:|.             .|..:..|..:     :|:.|. |....|.||..:.|
Mouse   559 QNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAGSITHLVSAF-LTADNISHGLLLKK 622

  Fly   409 HPVLMRLAKYLNIALEVCPVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSP------------ 461
            .|||..|.....|.:.:.|:||..|.|  :|..:|....:.:.:.:.:::..|
Mouse   623 SPVLQYLYYLAQIPIAMSPLSNNSLFL--EYSKNPLREFLHKGLHVSLSTDDPMQFHYTKEALME 685

  Fly   462 ------GFWRAAP---------------LSHDFYMAFLG-----IAPMNADLK----------FL 490
                  ..|:.:.               |||.....|||     ..|...|::          |.
Mouse   686 EYAIAAQVWKLSTCDLCEIARNSVLQSGLSHQEKQKFLGQNYYKEGPEGNDIRKTNVAQIRMAFR 750

  Fly   491 KRTAKNSIKYSSLKDEAKAE 510
            ..|..|.:.:  |.|..|:|
Mouse   751 YETLCNELSF--LSDAMKSE 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	adm_rel	52..527	CDD:273620	120/612 (20%)
Ampd3	NP_001359370.1	AMP_deaminase	137..767	CDD:437158	132/667 (20%)