DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-E and ada2

DIOPT Version :9

Sequence 1:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_031754454.1	Gene:	ada2 / 100487564	XenbaseID:	XB-GENE-6258151	Length:	513	Species:	Xenopus tropicalis

Alignment Length:	490	Identity:	192/490 - (39%)
Similarity:	281/490 - (57%)	Gaps:	35/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 VGNDIQLTLPERAANELIMCEKKREYEK----GIMDPSKFAPGHHIFQVLTKVKKSPLFQILRRM 128
            :|.:|.||..|..||..:|..|:.|.::    |:     |.|..|.|:....:::|.:|.|:|:|
Frog    38 LGGNIILTPSEATANWKLMTVKEAEIKEAERTGL-----FPPSMHFFKARPLIQQSKIFSIVRQM 97

  Fly   129 PKGAALKAHDTSMCS-SRVVIEITYRDNLWVCTTQNGCRVEEFRFAKDKPKDVSF---ENGEWQP 189
            ||||||..||.::.| ..:|...||..:.::|.|::|    ..||...||..|..   ...||..
Frog    98 PKGAALHLHDFAILSVDWLVKNATYMQDCYICFTRDG----GVRFLFSKPAPVGMLPPGCSEWVL 158

  Fly   190 MEKLRELRG-----EENLRKYLQMRFSMYPLASFTTNAHAWRHMMGIFGLLDGLLQYAPVWGDYY 249
            :|..|:..|     ::.|.:.|.: .:..|.....:....||...|.|....||:.||||:.:|:
Frog   159 LETYRKKLGDVTEFDKGLIRNLTL-LAESPEPHIPSQDEIWRRFEGAFITASGLICYAPVFKEYF 222

  Fly   250 YNALKEFYADGVQYLEVRSVLPQLYSLDGSRMPKRETVQIYKDTLERFKKEHPGFIDSKLIYAPI 314
            |.:|||.|.|.:||:|:|::||.:|.|||:......::.:|:|...:|...||.|:.:|:||...
Frog   223 YESLKELYEDNIQYIEMRAMLPPVYELDGTVHDPFWSMALYRDVTNQFIGAHPDFLGAKIIYTVH 287

  Fly   315 RHVQPELVGEYIKECTELNKEFPSFVVGFDLVGQEDVGHPLSNFAAEL-------LKLPDHIHFY 372
            ||.....|.:.:....||.||||..:.|||||||||.|:.|...:..|       :|||    ::
Frog   288 RHEDLARVTQAVHLAMELMKEFPEIMAGFDLVGQEDAGNSLYQLSDALNIPSKLGVKLP----YF 348

  Fly   373 FHAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPVLMRLAKYLNIALEVCPVSNQVLQLGS 437
            ||||:|||.|..||:|:|||::|.|.||||||.:.||||...|:..:.:.||:||:|||||.|.|
Frog   349 FHAGETNWQGKDVDENVLDALLLNTTRIGHGYALLKHPVARNLSLKMEVPLEICPISNQVLLLVS 413

  Fly   438 DYRSHPAATLIAENVPMVIASGSPGFWRAAPLSHDFYMAFLGIAPMNADLKFLKRTAKNSIKYSS 502
            |.|:||||.|:||..|:|::|..|..:.|..||:|.|...:||....|||:.||:.|:||||||:
Frog   414 DLRNHPAAVLMAEGHPLVVSSDDPSIFGAQGLSYDIYEVVMGIGGAKADLRTLKKLAENSIKYSA 478

  Fly   503 LKDEAKAEAMEKWKKQWDKWVENIVRQRKKDSETE 537
            |..|.||:..|.|:::|||::|::. ...|.||.|
Frog   479 LSKEGKAKLTEIWQRKWDKFIEDLA-MNSKTSERE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	17/60 (28%)
		adm_rel	52..527	CDD:273620	188/478 (39%)
		ADGF	105..519	CDD:238646	172/429 (40%)
ada2	XP_031754454.1	adm_rel	25..503	CDD:273620	188/478 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1995
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2359
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		otm48092
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3910
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060