DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Had2 and cryl1

DIOPT Version :9

Sequence 1:	NP_610974.1	Gene:	Had2 / 36624	FlyBaseID:	FBgn0033949	Length:	315	Species:	Drosophila melanogaster
Sequence 2:	NP_001038806.1	Gene:	cryl1 / 751596	ZFINID:	ZDB-GENE-060810-7	Length:	315	Species:	Danio rerio

Alignment Length:	317	Identity:	141/317 - (44%)
Similarity:	204/317 - (64%)	Gaps:	7/317 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSQK---IGIVGSGLIGRAWAMLFAAAGYRVQLYDILESQLATALQELDKDLHRLEEQSALRGN 62
            |||.|   |.:||||||||:|||:|.:.||:|:|||....|.:.|:.|:.|.|..|::...||||
Zfish     1 MSSLKEKIITVVGSGLIGRSWAMVFLSGGYKVKLYDNKPGQASGAIAEIRKQLEELQQAKMLRGN 65

  Fly    63 IRASEQFALIGVTTRLEELTREAVHIQECVPEVLHLKKSLYSQLDELLEEQTVVASSTSTFMPSL 127
            :.|:||.:.:.....|::....|..:||.|.|.|..|:|::..::||:.|..:::||||..|||.
Zfish    66 LSAAEQLSRLSSHEDLQQALDGAFFVQESVFEDLEAKQSVFHAVEELVSESVILSSSTSCLMPSN 130

  Fly   128 YSEGLQKRQQMLVAHPLNPPYFIPLVEIVPAPWTSPSAVERTRDLMLSLGQRPVTLKREIQGFAT 192
            ....:|.|.:.:|:||:||||::.|||:||.|.|.|:.:|....||..:||.||.|::||.|||.
Zfish   131 VFSQVQNRTRCIVSHPVNPPYYVRLVELVPHPETLPAVMEVAYSLMTDVGQAPVRLRKEIDGFAL 195

  Fly   193 NRIQYAILNEVWRLVGSGILSVADVDRVLSQGLGLRYALLGSLETAHLNAPGGVADYFQRFGGEI 257
            ||:||||:.|.||||..|::||.|:|.|:|:|||:|||.:|.:||.|||||.|:.||.||:...:
Zfish   196 NRVQYAIIAESWRLVQDGVISVKDIDLVMSEGLGMRYAFIGPIETMHLNAPEGMKDYLQRYSEGM 260

  Fly   258 SAVSATYGETPNTQEDRETLAEIARQCEQLV--SLEKLDERRAVRDEFLIQLAKLKK 312
            ..|..|:|..|:.  ..|..|.:.::..:|:  ..|.|..||..||:.|:.|||||:
Zfish   261 KRVLNTFGPVPDF--SGEPAARVIKEICELIPGKQEHLSARRERRDQLLMGLAKLKE 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Had2	NP_610974.1	PRK06129	5..312	CDD:235706	137/311 (44%)
		3HCDH_N	5..184	CDD:280833	76/181 (42%)
		3HCDH	189..>256	CDD:279114	40/66 (61%)
cryl1	NP_001038806.1	PRK06129	9..314	CDD:235706	135/306 (44%)
		3HCDH_N	9..187	CDD:280833	75/177 (42%)
		3HCDH	192..>262	CDD:279114	40/69 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581275
Domainoid	1	1.000	163	1.000	Domainoid score	I3924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2725
OMA	1	1.010	-	-		QHG62303
OrthoDB	1	1.010	-	-		D462830at33208
OrthoFinder	1	1.000	-	-		FOG0006346
OrthoInspector	1	1.000	-	-		otm26613
orthoMCL	1	0.900	-	-		OOG6_105634
Panther	1	1.100	-	-	O	PTHR48075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3389
SonicParanoid	1	1.000	-	-		X4620
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.940