Protein Alignment Had2 and CRYL1

DIOPT Version :9

• Sequence 1: NP_610974.1
• Gene: Had2 / 36624
• FlyBaseID: FBgn0033949
• Length: 315
• Species: Drosophila melanogaster
• Sequence 2: NP_057058.2
• Gene: CRYL1 / 51084
• HGNCID: 18246
• Length: 319
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 150/321 - (46%)
• Similarity: 215/321 - (66%)
• Gaps: 10/321 - (3%)

  Fly     1 MSSQKIG---IVGSGLIGRAWAMLFAAAGYRVQLYDILESQLATALQELDKDLHRLEEQSALRGN 62
            |:|...|   |||||:|||:||||||:.|::|:||||.:.|:..||:.:.|::..||:..:|:|:
Human     1 MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGS 65

  Fly    63 IRASEQFALIGVTTRLEELTREAVHIQECVPEVLHLKKSLYSQLDELLEEQTVVASSTSTFMPSL 127
            :...||.:||.....::|....|:||||||||.|.|||.:::|||.:::::.:::||||..|||.
Human    66 LSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSK 130

  Fly   128 YSEGLQKRQQMLVAHPLNPPYFIPLVEIVPAPWTSPSAVERTRDLMLSLGQRPVTLKREIQGFAT 192
            ...||...:|.:||||:||||:|||||:||.|.|:|:.|:||..||..:||.|:.:::|:.||..
Human   131 LFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVL 195

  Fly   193 NRIQYAILNEVWRLVGSGILSVADVDRVLSQGLGLRYALLGSLETAHLNAPGGVADYFQRFGGEI 257
            ||:||||::|.||||..||:|.:|:|.|:|:|||:|||.:|.|||.||||. |:..|..|:...|
Human   196 NRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAE-GMLSYCDRYSEGI 259

  Fly   258 SAVSATYGETPNTQEDRETLAEIARQ--CEQLV-SLEKLDERRAVRDEFLIQLAKLKKQFE 315
            ..|..|:|..|   |.....||...|  |.::. ..|.|..||..|||.|::|||||.|.:
Human   260 KHVLQTFGPIP---EFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQ 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Had2	NP_610974.1	PRK06129	5..312	CDD:235706	146/312 (47%)
		3HCDH_N	5..184	CDD:280833	86/181 (48%)
		3HCDH	189..>256	CDD:279114	37/66 (56%)
CRYL1	NP_057058.2	3HCDH	9..314	CDD:332468	145/308 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147532
Domainoid	1	1.000	185	1.000	Domainoid score	I3390
eggNOG	1	0.900	-	-		E1_COG1250
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2561
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62303
OrthoDB	1	1.010	-	-		D462830at33208
OrthoFinder	1	1.000	-	-		FOG0006346
OrthoInspector	1	1.000	-	-		otm40619
orthoMCL	1	0.900	-	-		OOG6_105634
Panther	1	1.100	-	-	O	PTHR48075
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3389
SonicParanoid	1	1.000	-	-		X4620
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800