DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12863 and F33A8.4

DIOPT Version :9

Sequence 1:	NP_610973.3	Gene:	CG12863 / 36623	FlyBaseID:	FBgn0033948	Length:	437	Species:	Drosophila melanogaster
Sequence 2:	NP_496368.1	Gene:	F33A8.4 / 174691	WormBaseID:	WBGene00009352	Length:	467	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	112/409 - (27%)
Similarity:	191/409 - (46%)	Gaps:	95/409 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PED---QHPRCEHGPTVLFNRQSQLP--DQGYYACSAHRD-SKLCNYHLPADQWKGQ-------- 70
            |.|   |.|:|.|||.:||.:::. |  ::.::||:.:|: ::.|::.|..::..|:
Worm    73 PTDDLPQVPQCSHGPCLLFEKKNG-PEVEETFFACAIYRNQAEFCDFKLTFNKETGEIEVKEAVE 136

  Fly    71 ---------------------TTRTALTKRDYPLPCRKPAN------PAICD---------PTLS 99
                                 ...|.::..|..|.|:...|      ..:|:         ||..
Worm   137 GEEDAEKKKKKKKIFGYNRIPKALTEMSPTDTVLYCKTCINVFPNKHECVCEPVEREALERPTHL 201

  Fly   100 LTALSQDKVNAQYFFDEAALNFLANQCEHIGASKVICMGAPRLHFHLR--HKLQS-FLLDLDERF 161
            |..:::....:|:||....|:.:....|......::|:||||:..::|  |..:: ||||.|:||
Worm   202 LPPVNEQHGESQFFFSTETLDVITKAVEKSKVDGILCIGAPRIFENIRALHPEKNVFLLDYDKRF 266

  Fly   162 AEYLGPEEFCLYNMCNNHF-----------FYDRTPFEQFLAGTSSDRLVIVTDPPFGCRTELIS 215
            |::...:::..|:|..:||           |:|:           |..::::||||||...|.:.
Worm   267 AKFFPSKQYAQYSMLVDHFFDKIAEPKLMEFFDK-----------SKSILMITDPPFGVFMEPLL 320

  Fly   216 HTLRSLRKLHNQINRLPST--PLSIFW---IYPYYSANHIRQEMPELEMCEYRINYTNHLRYTNV 275
            .::..::|      |..||  ..::|:   :.|.|...::..  ....|.:||:.|..|..|.:.
Worm   321 KSIEKMKK------RFVSTGKEETLFYSMIVLPIYIRKYVLH--GNFWMSDYRVTYEGHKLYQHS 377

  Fly   276 GKQSRFCGSPVRLFTNVPLRLLQLPPEEGYKYCQKCDCYTAKENLHCNRCGKCPSVNGQTYKHCE 340
            .|      :.|||||::|:..:.|....|||:|:.||.|..:.|:||:||..|.||....:.|||
Worm   378 EK------TIVRLFTDLPVECIDLKNVAGYKFCEVCDRYVTERNVHCDRCQACTSVEQGKWNHCE 436

  Fly   341 SCDACVKPNYVHCSDCRRC 359
            .||.||||.||||:.|.||
Worm   437 KCDKCVKPRYVHCAQCARC 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12863	NP_610973.3	N6-adenineMlase	111..>224	CDD:287239	34/126 (27%)
CG12863	NP_610973.3	PTZ00368	299..416	CDD:173561	32/61 (52%)
F33A8.4	NP_496368.1	N6-adenineMlase	210..361	CDD:287239	41/169 (24%)
F33A8.4	NP_496368.1	DUF3795	404..452	CDD:289445	25/47 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164762
Domainoid	1	1.000	64	1.000	Domainoid score	I6706
eggNOG	1	0.900	-	-		E1_KOG4399
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14632
Inparanoid	1	1.050	170	1.000	Inparanoid score	I2759
Isobase	1	0.950	-	0	Normalized mean entropy	S5886
OMA	1	1.010	-	-		QHG46102
OrthoDB	1	1.010	-	-		D312577at33208
OrthoFinder	1	1.000	-	-		FOG0005131
OrthoInspector	1	1.000	-	-		oto18029
orthoMCL	1	0.900	-	-		OOG6_107511
Panther	1	1.100	-	-	LDO	PTHR13493
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3585
SonicParanoid	1	1.000	-	-		X6245
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790