DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-HP2 and CG1647

DIOPT Version :9

Sequence 1:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster
Sequence 2:	NP_651636.1	Gene:	CG1647 / 43401	FlyBaseID:	FBgn0039602	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	1426	Identity:	283/1426 - (19%)
Similarity:	501/1426 - (35%)	Gaps:	387/1426 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 ENP---------ETETVNLEVPIKQDELVSDLDNAKELTGST-----NLPQ-------DDI---- 598
            :||         |.:|::|:.|....::.       ||.|.|     .:||       |.|
  Fly    26 DNPGKVPILLPNEEDTIDLDEPRMSQKIY-------ELVGFTVSVDDKMPQTICSQCVDKINDFY 83

  Fly   599 ---EM--ASNHQETDLKCAPDRVALDKSESTPKVEEEQLCKVDTPSDTALDESKVSESAKNHIEL 658
               ||  |:|.|..:|      :.|.:.|....::.:::.|.:.|...|:  .|.....|.....
  Fly    84 EFREMCYATNKQTRNL------LGLKQIEPARLIDLKRIVKEERPISGAV--GKRGRKRKGEESW 140

  Fly   659 EDKDKDKEETQKESPNGNSKETNENSVIVTNEVELPAKK-AEAKAEAGNIVEESDSQLAEDFKLA 722
            ...:..|.:.:|||...:.|:..:.|.|.:    |.:|: .|.|.|..    |.|:.|.
  Fly   141 PKNNNVKPQVKKESFVWHKKQKLQPSQITS----LVSKREPEIKDEPA----EQDTSLK------ 191

  Fly   723 EEILAAEVGKGVEANEVSVTSVQGEQNPVIEIVKELEQETISEV-VPA------------QNDQS 774
                    |...:|...|:.||.||:    .:.|||..|..|.| ||:            .::||
  Fly   192 --------GPPKKAGRKSICSVCGEK----FLSKELADEHKSLVHVPSIPRYICNACNQTHHNQS 244

  Fly   775 SVEDQTLADKENPVEKPSPVKAPSSSKDEPPA--------EENLPAPDQDPIEQQKTPVAKNQQH 831
            .:....|..|.:    .:|.|.|........|        |...|.|.|..:..::.|:.|
  Fly   245 DIRAHQLWHKLS----KTPYKCPLCESSVANAYAFTRHLREHTPPTPVQLLVLDRECPLCK---- 301

  Fly   832 DKEHNEAPKAESLSVSDIPSSSVTPSKKRNHSSPANTPKKSKEIEALQSSVPRRALRSDKATPQN 896
                      ::...:...::.....:||.....:.|............:.|:..|...|.....
  Fly   302 ----------KTFVTNFFYNTHRCAIRKRKCGGCSRTLNTEAAYMRHAPTCPKIYLNHSKHIMPQ 356

  Fly   897 LRESRSKRTLKTEL---------------TLLMDDTM-------RRSSPRLGRS-------PAES 932
            :..:.::..:|.|:               ..::|:.|       |.|||.|..|       .|:|
  Fly   357 VVTNEAQMLIKNEIEEELLGLPPATTVPPDFVIDEGMQPVVVLERLSSPLLRSSSGTDQLVAAKS 421

  Fly   933 HSSHERSPMEKKVTVSKLAKD----LITIDKEKEIELKSL-PDASETKDVKITKTTTASDTSILT 992
            .:|...|.......|.:|.|:    |::|..|.|:.:... |...:                  .
  Fly   422 KNSDRVSARNYLKRVDQLLKNTINTLVSIKHEPEVHINDTGPPRGQ------------------A 468

  Fly   993 DENPSSSKTEMKKLKGKPLKAKK---MSRTSETEVKKAIADSNEDIPSIFSIKCVEEHLTSSESE 1054
            :.:|...:.|.....|..::|..   .....|||..|....:.:||||: |:|...|:  ....:
  Fly   469 ESDPEPERNEEHPSFGDDIQAANDECQECQPETESDKISVAACDDIPSV-SVKQEPEY--DGYEK 530

  Fly  1055 QKDEKEELLCPKPQIDCTNTDLEQSTAIETDTEQVEEKRSNRRKSRRIRNEKFK---TETD---T 1113
            |...|:|.|..|.:|...:..|..|...:.|.......||:::|.:|...|:.|   .||:   |
  Fly   531 QTGVKQEPLKLKLKITKNHGKLNSSLIDDLDEAGQAFGRSSKKKKKRKHKEREKEASNETENCRT 595

  Fly  1114 LSDHLDAKKAENASLEISMRPKCTLETQQSDPVT--AKNKRNSGRLSRKEKSVINAAKSEKDKSP 1176
            .|.:..|.|.:...::.:  |:.|:.|  :.|:|  ..:...|.|....::::|   :|::|..|
  Fly   596 ESQNQPAIKIKQEPVDYA--PEATVMT--TIPMTQFESSLNESERSEEVDEAMI---QSQEDVKP 653

  Fly  1177 SAISQSTERKQLLNENPSKKDKKTEQSGNKKEAVVGPLDKTETSSSTNIIDKKSNESFDSAMQPS 1241
            :.:  ..:|...::...|..|...|....::.....|.|......|.....:||....:......
  Fly   654 NRM--ELDRMMQISNVTSGVDMAEEAMALERAEEACPEDSLHKVKSVKSTARKSTGGAERKTYSP 716

  Fly  1242 DRLN---------QKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDSNPTIRDTGEDSRQTDKK 1297
            .|.|         ..||||..:|        :|.:.::|..    ||..|      ||.|:|.::
  Fly   717 PRTNTLPQIVAVVSGESAFNMIS--------IKPEPRNLGY----GDEEP------EDQRETTEE 763

  Fly  1298 HQENDTKHEEED----------SSKLKANIDETK---------SSSEKDAEPISKD--SSQDSAK 1341
            ...||...||::          |.|.:..:|..:         ..|::|.:..::|  ||.|.|:
  Fly   764 INHNDMMEEEKEYIGSLDLSDVSVKQERELDICEIDAVHRNGLEKSDEDDDDGNEDSASSADEAE 828

  Fly  1342 PRLSKPKSRNKRKKNEKKP----NDSIAESDIEGGFQVNTETVQATCSTPSESNKKDMVKSDETN 1402
            ..:.:.......::.|..|    |:| :..|:|.. :::||...|..::.:.|..:|:
  Fly   829 EAMERDTEERIYREIELPPLELQNES-SRKDLESE-RMDTEVSTALPASETPSQTRDV------- 884

  Fly  1403 EEPNLSETEIGRIRKRGQAFHIENPKDDLHITPQNENQSIAGVNFEKQ-VPLPESVESDTPIMKI 1466
                     :|..:....||                  |:...|...| ||.|.:..|:.
  Fly   885 ---------LGVEKSEASAF------------------SLVITNICSQAVPQPSAACSND----- 917

  Fly  1467 PTKTYLMCTKNKTSLLSASEDPDIVLEPQKLITTSKGDSNPDLDNANNLETS--------STQDP 1523
                 :.|        |....|....||..  .|.:...:|    ||:|:||        |..||
  Fly   918 -----IEC--------SIGPSPSTTNEPHS--HTVENVQSP----ANDLQTSAQVAIAAQSQPDP 963

  Fly  1524 ---KEHEFSDQTFTDNSDIIPSCTKKSQIVFPTTPTKSSDQTKNSFITP--NRSPKSKRNVSKEA 1583
               .:...|.::..|..|:.|:.   |||           ||.|:...|  ..|.....::..:|
  Fly   964 CIVSQPAASSESQADTKDLPPAA---SQI-----------QTFNTESLPIHVHSETEDNSIENDA 1014

  Fly  1584 KRLDNSFE-ESQNAASESSASKVQKELRTPTASCRKLRVLIKRTPTSSLPTNSRKSIFKKTPAKS 1647
            ..|::..: :.|:|.:|:.:..:::....|:.||      :...|.:..|.||
  Fly  1015 SYLESRAQVDCQSAGTENPSVVLEQNESLPSGSC------VSPIPENPSPGNS------------ 1061

  Fly  1648 KRLTKILESMEKTPSREPSVSLGEVNPDSDPVAAES----VAVLHESDRDLESNEIPN-EEVFED 1707
                        .|..:.|.||     |...:||.|    ..|..::.:|.|:..:|. :....|
  Fly  1062 ------------PPQHDESESL-----DKPEMAAGSAYCLATVSLDAPKDTEALALPPCDAAIID 1109

  Fly  1708 TEEASAEDTDNKLKKKEDDHEL---EVNDICAASKNPITDDSTKDASSNKSTDSDVLQETKDELS 1769
            :...|.|:..|.|..:..:.:|   |...:....:.|...:......|::.     ::||::.::
  Fly  1110 SNYTSDEEQQNVLNHELSEQQLAIMEHRQLLVHEEQPALLEVIPPGLSSRP-----IEETENRIN 1169

  Fly  1770 NSLINATQGEDTPIKELTEEEVPNNKTVEDESKKQEILKDLEPDNAALEEDTASTAKAAEE 1830
            ....:..|||:.|         |..: ..|:|...||.::  .:||.:|.:....|..|:|
  Fly  1170 EQQQDLEQGEERP---------PRFQ-ANDDSNINEIAEN--NNNANIERELQDDALGAQE 1218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596	59/279 (21%)
		PTZ00449	<739..1091	CDD:185628	79/409 (19%)
		PTZ00108	<1132..1374	CDD:240271	56/277 (20%)
		PTZ00121	<1720..>2291	CDD:173412	22/114 (19%)
CG1647	NP_651636.1	zf-AD	19..99	CDD:285071	19/79 (24%)
		C2H2 Zn finger	203..224	CDD:275368	9/24 (38%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		C2H2 Zn finger	262..282	CDD:275368	2/19 (11%)
		C2H2 Zn finger	297..314	CDD:275368	2/30 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900