DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-HP2 and Lmpt

DIOPT Version :9

Sequence 1:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster
Sequence 2:	NP_996113.2	Gene:	Lmpt / 39889	FlyBaseID:	FBgn0261565	Length:	2147	Species:	Drosophila melanogaster

Alignment Length:	2558	Identity:	470/2558 - (18%)
Similarity:	850/2558 - (33%)	Gaps:	769/2558 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 PADSSTSQLGHVRKLTYSSERLDQPEPLGTQLRR-SKSESLPK--------------RGRPRGQK 494
            |.|||........:|....||||:      |::. ::.|:|..              |..|.|.|
  Fly    43 PGDSSVDAAADAEELPRMRERLDK------QIKEAAEREALAGTNVMQDGVLYVNGIRVDPAGDK 101

  Fly   495 QRKNRGATMEEKSANCRDGEGEPVKRKRGRPRKIIPKEEAKTAETENTIESLNTNVPLSIDTSKE 559
            ::     .:..:.|..:..|.:        .|:.:.:.|||..|..           |.:...||
  Fly   102 RQ-----ALAAELARQQQIEAD--------TRRQLAEAEAKLVEER-----------LRVQREKE 142

  Fly   560 NPETE---TVNLEVPIKQDELVSDLDNAKELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKS 621
            ..|.:   .|..|...::::...:|...:|                          .:|..|:..
  Fly   143 ESEEQQRKLVEAERQREREQAEKELQEQRE--------------------------AERRQLEAE 181

  Fly   622 ESTPKVEEEQLCKVDTPSDTALDESKVSESAKNHIELEDKDKDKEETQK---ESPNGNSKETNEN 683
            |:..|..|              :|.|  |..:|...|.|.::::||.::   |:.....:|.:|.
  Fly   182 ENQRKQRE--------------NEEK--ERLENERRLIDAEREREENERRLQEAEEQREREESER 230

  Fly   684 SVIVTNEVELPAKKAEAKAEAGNIVEESDSQLAE-----------------------DFKLAEEI 725
            .::|.......|:..:.:||...|:.|:::..||                       |.::.|.:
  Fly   231 RIVVAERQREQAEAEKERAEQQRILAEAEAAQAERRLFDAEIQRERDQADEEGQALRDAEIVERL 295

  Fly   726 LAAEVGKGVEANEVSVTSVQGEQNPVIEIVKELEQETISEVVPAQNDQSSVEDQTL----ADKEN 786
            ||||       .|:|.::.:.|......|. |..:..||.....:..|..:|:...    |::|.
  Fly   296 LAAE-------RELSPSATESELEEDAAIA-EQSRRLISSRTDLEQKQRMIEENARRFLEAEEEM 352

  Fly   787 PVEKPSPVKAPSSSKDE-------PPAEENL------PAPDQDPIEQ---QKTPVAKNQQHDKEH 835
            .:.:...::| |.||:|       .|..|.|      |...|:|.|:   .|......|....|.
  Fly   353 VMLQQRQLQA-SHSKEEADEYAGMEPVVEELCVKKVAPPRFQEPPEEPMVHKVKTQFGQGSGPED 416

  Fly   836 NEAPKAESLS---VSDIPSS--------------SVTPSKKRNH-SSPANTPKKSKEIEALQ--- 879
            ..:.|:::|:   |||..||              |..||.:.|. .|....|:...:|:.:|
  Fly   417 AYSAKSKTLTFPGVSDEGSSLEPKTPFSIQQSSFSTQPSDEGNRIESERPEPEGEDQIQEVQYTE 481

  Fly   880 ------------------SSVPRRAL--RSDKATPQNLRESRSKRTLKTELTLLMDDTMRRSSPR 924
                              .|..|||.  |....:..:.||||:.|..:.::...:::...|...|
  Fly   482 DYLRSLDGIKNRPLMREDGSGRRRAFKKRRSSGSSNSSRESRASRDEELKMFTSLEEEELRHGDR 546

  Fly   925 LGRSP----------AESHSSHERSPMEKKVTVSKLAKDLITIDKEKEIELKSLPDASET----- 974
            ...:|          .:||..|:|||          ||| :....|....|:.|.:.|..
  Fly   547 EDYNPIKYTSEPTLRVKSHRRHKRSP----------AKD-VRPTAESTTSLEMLGEESTNPWGEV 600

  Fly   975 -----KDVKITKTTTA--SDTSILTDENPSSSKTEMKKLKGKPLKAKKMSRTSETEVKKAIADSN 1032
                 ||.:..|...|  .|...:..|.||..:...::...:| |:......:|.:.::|:|
  Fly   601 VPEHYKDTEFWKREKALSIDEEEIELERPSRGEDVEEEATNEP-KSSSFEEATEAQNEQAVA--- 661

  Fly  1033 EDIPSIFSIKCVEEHLTSSESEQKDEKEELLCPKPQI----DCTNTDLEQSTAIETDTEQVEEKR 1093
                      .:::.|:..:.:::.||:     .||.    |...::|:.|.|.|   ||.....
  Fly   662 ----------ALKQQLSKEQLDKEAEKD-----NPQAVDTSDSNKSNLQTSIAAE---EQSRGGS 708

  Fly  1094 SNRRKSRRIRNEKFKTETDTLSDHLDAKKAENASLEISMRPKCT---LETQQSDPVTAKNKRNSG 1155
            ...|:|.|:         |.:..:.:...|......:..:|..|   :..||.|  ||.
  Fly   709 PGLRRSPRM---------DEMEHYPERWSASQEQQSVQQQPPRTAPAINVQQPD--TAP------ 756

  Fly  1156 RLSRKEKSVINAAKSEKDKSPSAISQSTERKQLLNENPSKKDKKTEQSGNKKEAVVGPLDKTETS 1220
              .|.:..::....|:.....::::.|..|....|.:|:.|:             |..|...:|.
  Fly   757 --WRDQYGLLMEGLSDFYDFTASVNPSRSRSASRNPSPAPKN-------------VANLMDGDTE 806

  Fly  1221 SSTNIIDKKSNESFDSAMQPSDRLNQKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDSNPTIR 1285
            .|..:.|..........:.....|...||...:..|.:...::.                  |:.
  Fly   807 RSLEVYDDTQEGVMAGELNCESVLQLLESNLNETESTNDQLQVQ------------------TVA 853

  Fly  1286 DTGEDSRQTDKKHQENDTKHEEEDSSKLKANIDETKSSSEKDAEP-ISKDSSQDSAKPRLSKPKS 1349
            |...|.:..      ....||..:||.|.|.::      |:..|| :.:..|:..::.|...|.|
  Fly   854 DDARDGKSI------LPMVHEPLESSALGAVLE------ERGREPSVGRIQSRSRSRSRSPLPTS 906

  Fly  1350 RN------KRKKNEKKPNDSIAESDIEGGFQVNTETVQATCSTPSESNKKDMVKSDETNEEPNLS 1408
            .|      ||::...|.||.:||              :.:.|:|.:|  .::..||.....|.|.
  Fly   907 ENLEKSIHKRRERLIKQNDELAE--------------RLSHSSPEDS--MEIETSDNGRLSPTLE 955

  Fly  1409 ET------EIGRIRKRGQAFHIENPKDDLHITPQNENQSIAGVNFEKQVPLPESVESDTPIMKIP 1467
            .|      ||..:        .:.|.:|...||:.                          |::.
  Fly   956 VTLPQPVIEINEM--------ADEPMEDAETTPEE--------------------------MRLF 986

  Fly  1468 TKTYLMCTKNKTSLLSASEDPDIVLEPQKLITTSKGDSNPDLDNANNLETS-STQDPKEHEFSDQ 1531
            .:| |...:|..|                   .|:..|...|..|.|:|.| .::..|..:.:|:
  Fly   987 VET-LRAERNARS-------------------RSRSRSRSPLPTAGNIEKSLESRRLKRIQHNDE 1031

  Fly  1532 TFTDNSD-------IIPSCTKKS-QIVFPT-------TPTKSSDQTKNSFITPNRSPKSKRNVSK 1581
            .|....|       ||.|.:..| .:..||       .|.:::..|:   ..|..:|:|...:
  Fly  1032 IFEKLHDQMSSPQIIIESASPPSLPLPLPTISIEIAEPPEENASHTE---AEPEDTPESMARL-- 1091

  Fly  1582 EAKRLDNSFEESQ-NAASESSASKVQKELRTPTASCRKLRVLIKRTPTSSLPTNSRKSIFKKTP- 1644
                    ||:.: |.....|.|:.:..|.|                    |.|..:|:.|:..
  Fly  1092 --------FEQLRLNRVRSHSRSRSRSPLPT--------------------PANLEQSVQKRRER 1128

  Fly  1645 --AKSKRLTKILESMEKTPSREPSVSLGEVNPDSDPVAAESVAVLHE--SDRDLESNEIPNEEVF 1705
              |::.:..::|:...:||  ||...|             :|..::|  .::|        |:|.
  Fly  1129 LIAQNDQFFEVLQERARTP--EPETRL-------------TVEYVYEYVQEKD--------EQVG 1170

  Fly  1706 EDTEEASAEDTDNKLKKKE---DDHELEVN----DICAASKNPITDDST-KDASSNKSTDSDVLQ 1762
            |..::.|...:.::.:.:|   ||..|.:|    ::....||....:|. ...:..:..|.|.|:
  Fly  1171 EGRDKRSLSPSRSRSQSQEKALDDFHLMLNLEGSELRTLRKNSEELESVLAVGAKQREVDMDALE 1235

  Fly  1763 E---TKDELSNSLINATQGEDTPIKELTEEEVPNNKTVEDESKKQEILKDLEPDNAALEEDTAST 1824
            :   ..:|:...:::.|..|...:.|:|.|....::||      .|:.:||:      :|..||.
  Fly  1236 KLHNANEEIELRVLSPTNSELERVVEMTRENPDMDRTV------SEVARDLQ------DELMASG 1288

  Fly  1825 AK----AAEEMDLYIKEKSNVKSVLAEPETDVTDDEELAQSPIPNSSETTSVTDDPEPSTSSVVK 1885
            .|    ..|.:||...:...::...|:        .:.::||.|.||...:       ...:..:
  Fly  1289 FKRSTYVGESLDLGSDQFKELRREAAQ--------FQRSRSPSPGSSMDYA-------REQAAAQ 1338

  Fly  1886 RSLRKREADSSQPDEAAKRKQRQDVEKSLTGKKEQVKPAR----RRQLAEVEERPSLKRS----- 1941
            |.|:....||........:.:....|:  ||:.|.:..|:    |.:.||.:...|..||
  Fly  1339 RELQTAILDSLTESRLGAKPKTYSEER--TGEFEDISAAQLDDLRHRTAEFQRSRSQSRSPLREV 1401

  Fly  1942 --------KTESEAKSTVQGKYISIIGNETIMSSTTAPIRETNREAASTSPSARKSAVQEAKHVE 1998
                    :.|| ||..:|.:.:..:...:|.....:  |..|.:...:...|..||:......:
  Fly  1402 ELTQLRDIEAES-AKRELQDQLLDRLAASSINFENFS--RHLNADFLDSERRASDSALMGDMEPD 1463

  Fly  1999 TTKHIILGPPGKKLLHSDSPAAE--------VKKPMVQTL------LSSTLSLQKPSTLDDG-SP 2048
            ...|.     .:..|..:.|..|        :.:..|:||      |.......:|:...|. ||
  Fly  1464 EYHHF-----RRYSLAQEQPVEEYPSDDYVYISQIEVRTLTGTRTWLKEDFYTHEPNDFSDSKSP 1523

  Fly  2049 LKIRKSLKKSI-ADE----NIDGDQSIFSSSSV-----LNKNTSVVAPRKVNISVSLLQSKDTQV 2103
            ::...|..::: |.|    ..|...:|:|...|     |::..|           |...|:||:.
  Fly  1524 VRDEDSWARAVLAAEAEAAEFDSTNAIYSYDIVGDHENLDQERS-----------SSNDSEDTRQ 1577

  Fly  2104 ETAASSSETP--------ILTKKEKLKTQKSTKKPEGNKKTESKKKSLVQGPQMKTQKSEE---- 2156
            .......|..        |....|  :||.:.:......:.|..:::..:......|..||
  Fly  1578 TVVEIDDEDEFEFELDEGISDNNE--RTQPTDESHHDTSECEEAERNADRYENRGAQDWEEVDDV 1640

  Fly  2157 -----------AVSG-----------PKILNKYLKSETESS-RKTVSTVTGRKQIGQLEVLKKPE 2198
                       ||.|           .:|.|:.:|:..:|. .:...|:...:....|...:|.:
  Fly  1641 EDFLDYGFDDGAVGGATPYSDPDSFIEQIYNEAIKNRKQSGILREYETIVQEQLPSDLSESEKEK 1705

  Fly  2199 SRKSEE---------SLVEAISRKKQSQVQ----RLSKIDGRKSEGTSLPQPD-VSKSETALKAA 2249
            |....|         .|..:.|..:.|.|.    .:.:.|.|.||...|.... |::..|.|:..
  Fly  1706 SGSDSEKYALWAKTRELERSHSGTRHSDVDIALGLIPESDHRDSEMRYLGDAHVVARQSTRLRTR 1770

  Fly  2250 LPKETEFPV----QDAEIEKMSKGRGHQNAVKNTKTEQPKSKPKTEVRSLQAEAATELMDSMDSQ 2310
            .....:..|    .|.|::...|.:...|..||.:.:..:          :.|.:.::....|.:
  Fly  1771 YGFNPKLEVGDLEDDIEVDLNYKPKREYNWRKNFRLDDNE----------EGERSVQVKTEEDEE 1825

  Fly  2311 SDVSDIRATFPESQGIFNVPGHMTRAISSNRSLAPTPTPMSDSQRNASKERFTPVSDQKKP---- 2371
            .:..|   .|.|..|                        ..|.::...:|.:   .|.::|
  Fly  1826 QEARD---QFEEEFG------------------------WQDREQELEEELY---QDHEQPLYAN 1860

  Fly  2372 -----IRESQTLSKRR-ARGGRNQPLVSKRKAGEAEDGTAVINPKRPREMDEEDHPQQNDHVQES 2430
                 |...:.|..|| :.||.:..|.|:....|       |.|..|.|:     ||:.:.::|.
  Fly  1861 EENGEIENVELLENRRISLGGESITLFSRSPVRE-------ILPDVPEEL-----PQEEEALEEQ 1913

  Fly  2431 AFAAFPVKITAASSVIPQVVRSTGNTVPQNISPRKLCVKINRRPYNKWLRSTQERNEEQEGSRNV 2495
            ..|..|::...|.                  .|:|       :...|.||...:..||
  Fly  1914 PEAVAPLEDLPAE------------------KPKK-------KKSKKKLRKGSKTEEE------- 1946

  Fly  2496 TSLPLLGETSETDSAAESMSESILQSQVQSEPAIQPLPASQPDSCTLQASDLRIRESSAQLAPIA 2560
                 |.:.:::|:...|...|  ..|..::|     |..:..|.....|.|...|.:....|.:
  Fly  1947 -----LRDDNDSDTQMGSSRRS--DDQEPTDP-----PKRKTRSRRSSRSSLTNEEPNGGSGPFS 1999

  Fly  2561 AYDSPAANDSSTSPALDIAPESAQTAKATLNTALCPSTEKHLPDEPTLLESSKKVAEPQKLQTFQ 2625
            ...|.|....|.....:..|:..:..::|                      .|:..:.:|..|.:
  Fly  2000 PRSSLAFVGESLEGIAEFEPQEREEEQST----------------------KKRTKKRKKTSTKE 2042

  Fly  2626 AKCLPVPIPEVKSEPE-DIMDEHSPNEPMPMVAAAPATPQPHAITEDAGPDTIQVNTLGVSTSSR 2689
            .|      .|.|.|.: ..:|:...:..:   |||.|...|.:::.:..|::...|.|...::.:
  Fly  2043 CK------EEAKEETQTQAIDDSQLDRAL---AAALAEIAPVSVSTNLTPESTHQNLLSTISTGQ 2098

  Fly  2690 PLELHSIPSASDPDGNPNAIGQT 2712
            .:.:....|..:..|:|::...|
  Fly  2099 SVCITPASSIEEIGGSPSSTSTT 2121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596	57/294 (19%)
		PTZ00449	<739..1091	CDD:185628	91/438 (21%)
		PTZ00108	<1132..1374	CDD:240271	47/251 (19%)
		PTZ00121	<1720..>2291	CDD:173412	126/680 (19%)
Lmpt	NP_996113.2	GBP_C	<103..201	CDD:303769	24/163 (15%)
		ARGLU	110..255	CDD:291991	35/205 (17%)
		coiled coil	170..181	CDD:293879	3/36 (8%)
		coiled coil	190..201	CDD:293879	4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900