DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-HP2 and Asph

DIOPT Version :9

Sequence 1:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster
Sequence 2:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	158/847 - (18%)
Similarity:	303/847 - (35%)	Gaps:	238/847 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1225 IIDKKSNESFDSAMQPSDRLNQKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDSNPTIRDTGE 1289
            |::.:..|..|:.:        .||.|:|:.            |..:|......|.:.....:||
  Fly    71 IMENRGLEDLDTPL--------SESRFSKVF------------DGWVDEHRDEHDGHDVQEPSGE 115

  Fly  1290 DSRQTDKKHQENDTKHEEEDSSKLKANIDETKSSSEKDAEPISKDSSQDSAKPRLSKPKSRNKRK 1354
            .....|:....:|.:.||..:.:|:..::|.:..:|:|.....::..:|..:...:......:..
  Fly   116 ALDDHDEHDDHDDHEDEEPLTEELEEELEEEEEPTEEDEPAADEEYEEDEDEENNAGENITAEDA 180

  Fly  1355 KNEKKPNDSIAESDIEGGFQVNTE-TVQATCSTPSESNKKDMVKSD----ETNEEPNLSETEIGR 1414
            :.|::..|:..|..:|...:..|| |.:||....:|.:.:|...:|    |:.|.| ||:.
  Fly   181 EEEEEEEDNDDEGTVEATVEATTEATTEATGEYEAEEDDEDEAAADDDAVESTEAP-LSKA---- 240

  Fly  1415 IRKRGQAFHIENPKDDLHITPQNENQSIAGVNFEKQVPLPESVESDTPIMKIPTKTYLMCTKNKT 1479
                      |..:||     ::|:        |::..:.||||.:               :::.
  Fly   241 ----------EEQEDD-----EDED--------EEEQEIEESVEPE---------------RSQY 267

  Fly  1480 SLLSASEDPDIVLEPQKLITTSKGDSNPDLDNANNLETSSTQDPKEHEF---SDQTFTDNSDIIP 1541
            :..||         |.|       |:|.| |:.::.:.:...|..:.||   :.|...|..|.:|
  Fly   268 AAQSA---------PAK-------DNNDD-DDDDDQDKNDADDGDDDEFESLAQQFENDPEDTVP 315

  Fly  1542 SCTKKSQIVFPTTPTKSSDQTKNSFITPNRSPKSKRNVSKEAKRLDNSFEESQNAASESSASKVQ 1606
            :                                  :.|..|.:..|.:.||.......|..:.:.
  Fly   316 A----------------------------------KAVESEEQDQDQADEEEPKEEGSSWLASLA 346

  Fly  1607 KELRTPTASCRKLR-VLIKRTPTSSLPTNSRKSIFKKTPAKSKRLT------KILESMEKTPSRE 1664
            .:.....|.....| |||:::|.::....:.::||:      :|||      .|.:.:|:.|..:
  Fly   347 VKFGVGVALALVSRLVLIRKSPNTTEDEPAPETIFR------RRLTIATAEDHIPDDVEELPPLD 405

  Fly  1665 PSVSLGEVNPDSD------PVAAESVAVLHESDRDLESNEIPNEEVFEDTE------EASAEDTD 1717
            ...|..|:..:.:      .:..|...|.|::|.::.|......|.||...      :...:|..
  Fly   406 DEYSEEEIEIEEEIEVEISDIEEEEEEVRHDNDDNVASMASYVPETFEQLSAMYKYAQEPTKDAK 470

  Fly  1718 NKLKKKEDDHELEVNDICAASKNPITDDSTKDASSNKSTDSDVLQETKDELSN----SLINATQG 1778
            .:.|:||.:..:..:||....::...:|...|..|    |.::..| :||:|:    .|:|..:.
  Fly   471 PEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVS----DEEITDE-EDEISDVDDADLMNRLEA 530

  Fly  1779 E--DTPIKEL---------------TEEEVPNNKTVED--ESKKQEILKDLEPDN--AALEEDTA 1822
            :  ..|:||.               .:|..|.....||  |.:.::..:::..:|  .||.....
  Fly   531 KYGRLPVKEFESDPDSDDPSWTQIKPKEAAPAPAEKEDPFEQELRKANEEMIRENYAQALRSFNT 595

  Fly  1823 STAKAAEEMDLYI-----------KEKSN---------VKSVLAEPETDVTDDE--ELAQSPIPN 1865
            .|...|.|...::           ||:||         .|..||..|...::.|  ...:|.|.|
  Fly   596 LTTNFAHEPSAHLGRARLLELLAKKERSNQRLWEAIDAYKRYLAFGELVASNQEFQTAGESCIEN 660

  Fly  1866 ------SSETTSV--------TDDP----EPSTSSVVKRSLRKREADSSQ-----PDEA------ 1901
                  ..:.|::        .:||    :.|.:.::..:|::.|..:.:     |:.|
  Fly   661 LRFLGHHRQATTIHELLINRLPEDPRLRNQLSLTYLMVNNLQQVEKVAVETLKLWPNNAVAQLHY 725

  Fly  1902 --AKRKQRQDVEKSLTGKKEQVKPARR--------RQLAEVEERPSLKRSKTESEAKSTVQGKYI 1956
              |.|:...|..|:|...|..|:....        ..|.|..:|.|:|....|...|...:|.:.
  Fly   726 GLALRQFHADYAKALPYLKYAVESGEEGTQEAFFYLSLGETMQRLSMKSEALEVYGKGVAKGFFA 790

  Fly  1957 SI 1958
            |:
  Fly   791 SL 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596
		PTZ00449	<739..1091	CDD:185628
		PTZ00108	<1132..1374	CDD:240271	25/148 (17%)
		PTZ00121	<1720..>2291	CDD:173412	65/325 (20%)
Asph	NP_001261020.1	TPR	610..854	CDD:223533	36/183 (20%)
		TPR repeat	684..714	CDD:276809	5/29 (17%)
		TPR repeat	719..748	CDD:276809	7/28 (25%)
		TPR repeat	757..782	CDD:276809	6/24 (25%)
		Asp_Arg_Hydrox	826..977	CDD:282913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900