DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)2-HP2 and CG43340

DIOPT Version :9

Sequence 1:NP_610972.2 Gene:Su(var)2-HP2 / 36621 FlyBaseID:FBgn0026427 Length:3257 Species:Drosophila melanogaster
Sequence 2:NP_001246184.1 Gene:CG43340 / 35698 FlyBaseID:FBgn0263077 Length:3213 Species:Drosophila melanogaster


Alignment Length:3315 Identity:630/3315 - (19%)
Similarity:1106/3315 - (33%) Gaps:1014/3315 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 TASSAGVPR------QRRISSDSSNSSSIDADIFQKLFHGKYLDDELLKEGSGSKSQDRRRRPPS 82
            |:.|:..||      ...|..|:..|.|:..|:.::.....|:...::.            .|..
  Fly   376 TSGSSIEPRSDCSLTDHEIGLDNGKSQSLQTDLERESVLSDYIAAHMVP------------LPDF 428

  Fly    83 PSSSDESNDALEALFCGKSSQSK-----LSKRRERYESFDSVDDLGEALMRPSHRLTVPKPSTSQ 142
            .:|..||.|.:.::..|......     |.|::....:..|:     .::.|:.|..|    .:|
  Fly   429 SASVTESEDDIGSISSGMIGDGNWEDNWLFKKKRSSATPSSI-----GMLVPAPRENV----RAQ 484

  Fly   143 AGSKKSQDAAPHRSISNSSSSNIAMSSGQTYAC--------------PKNKK--------TNSVA 185
            .|.|.:.:.:....|    .|:|..||.....|              .:|.|        ..|:.
  Fly   485 IGDKTTDEVSDLSEI----GSDIEESSLDLLRCNDLNDRLLSKHLIGGQNTKMVLDELVDRTSLT 545

  Fly   186 NKTAVSANGDKWASGKNKTVTIVKPQKTDLRPSRLEPKTDPLNLGD-------------LYGDSD 237
            :.|....|...:....|:.|.......:|::.....|...|:...|             ..|:|:
  Fly   546 SHTLPEENEPAFTETTNEFVVSPMAMPSDIKAPSPTPPPPPMIFQDDLLNEEPDHTPIAAQGESE 610

  Fly   238 SDSSYEYESDF----YGDQDSDEEDEP-VIDISTDTSRTTSVADTVTPVVSDDEGQEPQSEL-NQ 296
            ..||.:..:.|    |.|:....:..| ||:|        ..|..:.|:::....::|.:.. ::
  Fly   611 ELSSLDGCTGFSTVEYIDEGQMHDTVPSVIEI--------LAAMALGPMLAVPASEQPGAMTPSE 667

  Fly   297 RHANDQESFLSSTYERLQSYLSNLSSAEPPPIYKKQNSARKSRSNEKKPSSSQQVKHAN------ 355
            .|...:.|.|:  ...:.:...:|..|....|.:::|:         :||.:...:|.:      
  Fly   668 MHTLKELSDLA--LAEINARTVDLVHAHSLDIIEEENT---------EPSETGPEQHLDFVPHSP 721

  Fly   356 -EQSAASDK-------EANKKERDLEPP-----EASSSAKSSASKASGSRKLYDVANNATLEAVE 407
             |:.|.:|:       ...|...:.|||     :...:.......|:...:|.....||.:|.|.
  Fly   722 LEELATTDQTDVLPPPPQLKLIYETEPPPPIEMDQDINCMEPQYTAAIVPELEIPGQNAPVEIVS 786

  Fly   408 RMS------LDLAEQIMEIDVERSYEFEKRSASKSRSLSRSKIPADSSTSQLGHVRKLTYSS--- 463
            :|.      |:..:.:.||........|.:|..:|..:        :||:::.||.....|.   
  Fly   787 QMKADDVTPLESVQIVPEITPPTDIVPEDQSNVESIQV--------ASTAEVVHVPLPVESGPEI 843

  Fly   464 --------ERLDQPEPLGTQLRRSKSESLPKRGRPRGQKQRKNRGATMEEKSANCRDGEGEPVKR 520
                    :.:|.||.:..                          .:::.::....|.:.|.:|.
  Fly   844 PVPFEIVPDPVDPPEVINF--------------------------VSLDMETPMPLDYDPETIKL 882

  Fly   521 KRGRPRKIIPKEEAKTAETENTIESLNTN-----------VPLSID---------TSKENPETET 565
            .:|....::|.:  .||.....|..:..:           :|:.:|         |.:::..|.:
  Fly   883 DQGHVANLVPGD--PTASLSERIPEMIADPTAAALPEPSPIPVPVDNGTQLDELGTIEDDSHTTS 945

  Fly   566 VNLE--------VPIKQDELV-SDLDNAKELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKS 621
            |.:|        ||::.|.|. ||..|..|...:..:|.....:.|.         |..:|.|.|
  Fly   946 VPMESVSIVEPQVPVEADALTQSDPVNLLESLDNVEIPPLPGPICSE---------PANIAADSS 1001

  Fly   622 ---------ESTPKVEEEQL---CKVDTPSDTALDESKVSESAKNHIELEDKDKDK--------- 665
                     |||| :|...|   ..|||...||: ||.||......:|..|.:..:         
  Fly  1002 LPLEAAEPVESTP-IEVATLDSPQSVDTELPTAV-ESLVSVGMLKDVESVDVNGSETLGVSLGTD 1064

  Fly   666 ---------EETQKESPNGNSKETNENSVIVTN------------------------EVELPAKK 697
                     |||.|.|.:......|:...:|.|                        ||.:|.|.
  Fly  1065 SIVVTQPQAEETVKPSASVEIDSENQTVALVVNVPESQEISEEAVSSIETISPPFSTEVAVPVKS 1129

  Fly   698 AEAKA-EAGNIVEESDSQLAEDFKLAEEILAAEVGKGVEA------NEVSVTSVQGEQNPVIEIV 755
            .:.:. |:....|.:..:.:|...:|.||......:..|:      |..|:..|..|.:|.:||.
  Fly  1130 IDVETLESPGATEPASVEQSETVDIAPEIHNVNPSEHCESVPEANVNIPSMEIVPLENSPSMEIQ 1194

  Fly   756 KELEQETISEVVPAQNDQSSVEDQTLADKENPVEK--PS--PVKAPSSSKDEPPAE--ENL---- 810
            .||.|...|..|..|      |.|.:|....||.:  |.  ||:.||..:.:|...  |||    
  Fly  1195 DELPQTLESSSVDPQ------EVQPVAVDPLPVTEVVPDVVPVEPPSIVETDPETREIENLDPME 1253

  Fly   811 --PAPDQDPIEQQKTPV----------AKNQQHDKEHNEAPKAESLS-----------------V 846
              |.|:...|| ..||:          .|||.:...|.|   .:::|                 |
  Fly  1254 IKPDPESSTIE-NLTPIDSLAAVESIDVKNQINSSNHME---QQNISIEPQPTVPMDTIQPIEIV 1314

  Fly   847 SDIPSSSV-----TPSKKRNHSSP----------------ANTPK-KSKEIEALQSSVPRRALRS 889
            .::|.::|     |.:...:||.|                .:.|: .|:.||.|..:.|...:  
  Fly  1315 QEVPCNTVDLIATTEAVNADHSEPGEAGLISEVLQFHSSGGDLPETDSRAIEPLPLAPPAEVI-- 1377

  Fly   890 DKATPQNLRESRSKRTLKTELTLLMDDTMRRSSPRLGRSPAESHSSHERSPMEKKVTVSKLAKDL 954
             :..|....|..|.                 |.|....||:......:..|||...         
  Fly  1378 -EVVPLGSAELLSP-----------------SEPTEVVSPSAIALPEKPEPMENAT--------- 1415

  Fly   955 ITIDKEKEIELKSLPDASETKDVKITKTTTA---SDTSILTDENPSSSKTEMKKLKG-------- 1008
                   |||::.:  .|.| .|:|..|||.   ...|::....|.|:..|:|.::.        
  Fly  1416 -------EIEIEEM--VSPT-SVEIVPTTTEDLHQAESVVETARPVSAVEEVKPIEDSTAAIDKS 1470

  Fly  1009 ---KPLKAKKMSRTSETEVKKAIADSNEDIPSIFSI--KCVEEHLTSSESEQKDEKEELLCPK-P 1067
               .|::.:. |:.||.|..::: :...|.|::..:  ..||...||:.:....:......|: |
  Fly  1471 PQISPIEGEH-SQHSEKETPESV-EVGLDSPNVADVITTSVEVIPTSTTAVTTSDGASTEMPEPP 1533

  Fly  1068 QIDCTNT-----DLEQSTAIET-----DT---EQVEEKRSNRRKSRR-----------IRNEKFK 1108
            :|.|...     ::||:..:||     ||   |::..:..|...|.:           :.|.:.|
  Fly  1534 KIYCETAPPAAEEIEQNETVETLSVSADTTLPEEIVSQDGNLEASEQTASIDVTFQANLNNMESK 1598

  Fly  1109 TETDTLSDHLDAKKAE--------NASLEISMRPKCT-LETQQSDP---VTAKNKRNSGRLSRKE 1161
            ...:...|..::|:.|        :.::.:.:.|:|. :|...|:|   ..|.|...||....:|
  Fly  1599 GCVEVAVDVRESKEDETLMEPIAVDVAVPVEVVPQCAGVELGVSEPEEATPATNNLTSGENPPEE 1663

  Fly  1162 KS------------VINAAKSEKD--KSPSAISQSTERKQLLNENPSKKDKKTEQSGNKKEA--- 1209
            .|            .|:....|||  ||..|::        |:|:.:|.::|.:.....:|.   
  Fly  1664 VSELVDVEPRNPHEEIHTDSFEKDSQKSSDAVA--------LHEDNTKSEEKVDPPQVAEEVAPD 1720

  Fly  1210 --VVGPLDKTETSSSTNIIDKKSNESFDSAMQPSDRLNQKESAFTKLSSISSPKKIMKDQ----D 1268
              .:.|....|.|..|..:...:...||..::|...:            |..|..::|.:    :
  Fly  1721 IITLDPPSLVELSPDTQAMAIGNIAPFDIILEPESIV------------IEQPVPVVKPETIVVE 1773

  Fly  1269 KDLDALSKGGDSNPT----IRDTGEDSRQTDKKHQENDTKHEEEDSSKLKANIDETKSSSEKDAE 1329
            .|.:|:.......|:    ::|..|.::|     |.::.|..||||  ||.:|.|.......|  
  Fly  1774 SDPEAIDHTALLEPSVSAEVQDKVESAQQ-----QVSENKSVEEDS--LKVSIGERGEIISMD-- 1829

  Fly  1330 PISKDSSQDSAKPRLSKPKSRNKRKKNEKKPNDSIAESDIEGGFQVNTETVQATCSTPSESNKKD 1394
            ||:...:......|:..|.:..:....|...::|| .:.:|......:.|::.  |||.|..:..
  Fly  1830 PITPADAVSEQNFRVEDPITSTESTAVEVIASESI-NTVVEPVSVAQSPTIED--STPEEVTQCS 1891

  Fly  1395 MVKSDETNEEPNLSETEIG-----RIRKRGQAFHIE----NPKDDLHITPQNENQSIAGVNFEKQ 1450
            .|         |.::||:.     ::.::.|..|:|    ....||..:|::..|          
  Fly  1892 AV---------NSTDTEVASAAPIQVDQKIQPVHVELVSQIEASDLQESPKDTAQ---------- 1937

  Fly  1451 VPLPESVESDTPIMKIPTKTYLMCTKNKTSLLSASEDPDIVLEPQKLITTSKGDSNPDLDNANN- 1514
                  ||||              :.::..|...||...||:||...:..|:........:|.| 
  Fly  1938 ------VESD--------------SVDQAILTQVSETDSIVVEPSSPVKQSEDSQGEPPGSAQNV 1982

  Fly  1515 -------LETSSTQDPKEHEFSDQTFTDNSDIIPSCTKKSQI--VFPTTPTKSSDQTKNSFITPN 1570
                   ::.|:.::..|        ||...:.||...:.::  |....|.:.||..:.:.    
  Fly  1983 LDVGPVEMDQSAPEEVPE--------TDPVAVEPSVPVEEEVIEVIQPAPKEISDSVERTL---- 2035

  Fly  1571 RSPKSKRNVSKEAKRLDNSFEESQNAASESSASKVQKEL--------RTPTASCRKLRVLIKRTP 1627
             ......::..||:.:|.   .::||..|...|:::|||        ..|:|....|.::.:...
  Fly  2036 -DSLGNTDLVAEAESVDT---PAENAGPEIGTSELEKELLVVSTTIDEQPSAVLEPLVLICQAES 2096

  Fly  1628 TS---SLPTN---SRKSIFKKTPAKSKRLTKILESMEKTPSRE-------------PSVSLGEVN 1673
            |:   .||.|   ..:|:....|......|:..: :|..||.|             ..|.:|:..
  Fly  2097 TNLDHELPENLVPQGQSVPASLPTNLTIQTQPTD-LETQPSMELILQTETVDAEMVKPVDMGDST 2160

  Fly  1674 PDSDPVAAESVAVLHESD-RDLESNEIPNEEVFEDTEEASAED------------------TDNK 1719
            .|......|.|..|..|. ..||:.|:...|...:||...|:.                  |:.:
  Fly  2161 VDKSQETGEMVLKLESSKWEPLEATELVTMEPSSETESTCADSKIYANLVPQLDSVPLSVPTELR 2225

  Fly  1720 LK-KKEDDHELEVNDICAASKNPITDDSTKDASSNKSTDSDVL-QETKDELSN-------SLINA 1775
            :: :.|:.|..|         |||.:  |..:|.:....:.|| ||....|.|       ..::|
  Fly  2226 IQPEPEEPHAFE---------NPIPE--TVSSSEDLLEPAQVLIQEDPVALENLPGVPIVPDVHA 2279

  Fly  1776 TQGEDTPIKELTEEEVPNNKTVEDESKKQEILK-----------DLEPDNAALEEDTASTAKAAE 1829
            ...|.:|: |:|.:....|..|..|  .:.|:|           :..||..|:..||..:..||:
  Fly  2280 HNFEPSPV-EITSQSADTNAIVPVE--VETIMKPETEAPSPMAVESTPDLEAVALDTKESVPAAQ 2341

  Fly  1830 EMDLYI---------KEKSNVKSVLAEP---ETDVTDDEELAQ--SPIPNSSETTSVTDDPEPST 1880
            .:.:.:         :.|:....:.|||   ..::..:|:...  :.||..:||:|...:....|
  Fly  2342 AIPVEVVPETEHLTEETKNETAKMDAEPARISVEIVQEEQPLSLGNKIPVENETSSAPVEAPFDT 2406

  Fly  1881 SSVVKR--SLRKREADSSQPDEAAKRKQRQD--VEKSLTGKKEQVKPARRRQLAEVEERPSLKRS 1941
            .|:...  |:.::|:::|:.....:...:.|  :.:::|...:....|   |||.:::  .||..
  Fly  2407 VSIPASVDSVEQKESNASEEPHFGEDILKNDDAILETVTANADLSSDA---QLASIDQ--ELKDP 2466

  Fly  1942 KTESEAKST-VQGKYISIIGNETIMSSTTAPIRETNREAASTSPSARKSAVQEAKHVETTKHIIL 2005
            .||...|:| |...|          ....|..:.|..:.....|:.|.:                
  Fly  2467 ATEGIHKNTSVDSSY----------GDCFALGKATTHKYLRRQPNIRDT---------------- 2505

  Fly  2006 GPPGKKLLHSDSPAAEVKKPMVQTL---------LSSTLSLQKPSTLDDGSPLKIRKSLKKSIAD 2061
             ||.    .:|||.......:..|:         |.:|:..::..:|.....|....||..||.:
  Fly  2506 -PPS----DADSPKRSEPVNLFGTICKFYIKDKRLLATIERRRRRSLIMHKYLSSFDSLDDSIDE 2565

  Fly  2062 ENIDGDQSIFSSSSVLNKNTSVVAPRKVNISVSLLQSKDTQVETAASSSETPILTKKEKLKTQKS 2126
            ...|...|:|..   ||:             |||..|||.|..|..::  ||:           |
  Fly  2566 VAYDSHTSLFEE---LNE-------------VSLHSSKDIQPPTGRAA--TPV-----------S 2601

  Fly  2127 TKKPEG---------NKKTESKKKSLVQGPQMKTQKSEEAVSGPKILNKYLKSETESSRKTVSTV 2182
            ...|.|         ..|||:   .:|....:.|.|||..|:...:....|:::.||.       
  Fly  2602 EVDPIGLVDNCFAFETDKTET---DMVDDLSVDTDKSECIVNMKNMPKCDLETKIESD------- 2656

  Fly  2183 TGRKQIGQLEVLKKPESRKSEESLVEAISRKKQSQVQRLSKIDGRKSEGTSLPQPDVSKSETALK 2247
                .:..|:.|..|       .:|.|.:|.:....|                    |:::||..
  Fly  2657 ----NLESLDTLTSP-------CIVSAKNRVESLDFQ--------------------SRTDTAND 2690

  Fly  2248 AALPKETEFPVQDAEIEKMSKGRGHQNAVKNTKTEQPKSKPKTEVRSLQAEAATELMDSMDSQSD 2312
            |.|           ||:.......|   :|:.:.:............:.::.:.::.|.::.::|
  Fly  2691 ACL-----------EIDASDNPEDH---LKHLEVDVTVGDNVILRLDMASQTSCDMADELEVEAD 2741

  Fly  2313 ------VSDI------RATFPESQGIFNVPGHMTRAISSNRSLAPTPTPM----SDSQRNASKER 2361
                  :|||      ...|.:..|        :.:|.|:.|...|....    .||.:....:|
  Fly  2742 STIAFSLSDITYNFINEILFSDQLG--------SESIQSDESEPSTACETFNADGDSDQEFVSQR 2798

  Fly  2362 FTPVSDQKKPIRESQTLSKRRARGGRNQPLV--------SKRKAGEAEDGTAVINPKRPREMDE- 2417
            ...:.||:.  ..:.|.|........:.||.        |:|..|:..:|:...:.....|:.. 
  Fly  2799 VLVLDDQRS--LSTNTSSNNNVHTHLHLPLTQTNNPSAGSRRTNGKLTNGSLRWSGSYATELPNG 2861

  Fly  2418 -EDHPQQNDHVQESAFAAFPVKITAASSVIPQVVRSTGNTV--PQN-ISPRKLCVKINRRPYNKW 2478
             ....|.:|.|.:...... ::.....|:..:.|:...|.|  |.| .||..|..:|:       
  Fly  2862 GSSGAQPDDVVVDDDDVVL-LRRFVPGSIAEREVKKWYNAVEMPNNPYSPEALKQRIS------- 2918

  Fly  2479 LRSTQERNEEQEGSRNVTSLPLLGETSETDSAAESMSESILQSQVQSEPAIQPLPASQPDSCTLQ 2543
              .||||         ...:|.:..::|..:.|.:::|:                   ||....:
  Fly  2919 --GTQER---------YMDVPNISPSAEQKALASALTEN-------------------PDPPAPK 2953

  Fly  2544 ASDLRI-RESSAQLAPIAAYDSPAANDSSTSPALDIAPESAQTAKATLNTALCPSTEKHLPDEPT 2607
            |...|. |:.....||.:...:.....::||...|:.                            
  Fly  2954 ADYKRYSRDYYINNAPTSTDSTGGGKAATTSAGEDVE---------------------------- 2990

  Fly  2608 LLESSKKVAEPQKLQTFQAKCLPVPIPEVKSEPEDIMDEHSPNEPMPMVAAAPATPQPHAITE-- 2670
                                  .:.|.||..|||    .|.|:..:...|.:.|....|....  
  Fly  2991 ----------------------DIVINEVNQEPE----PHPPHGRISSGAQSTAADLSHWTLSTP 3029

  Fly  2671 ----------DAGPDTIQVNTLGVSTSSRPLELHSIPSASDPDGNPNAIG--------------Q 2711
                      ::.|......:||...|. |||.   ||.|......:::|              .
  Fly  3030 VRRSSSLKFINSRPFHSPSPSLGYERSV-PLER---PSTSASHYRESSLGLGDDDDFDLRSQRSW 3090

  Fly  2712 TKMYSFLYPKRYKQSYDDVGLDFCCPNLDGPMRAIDFTRLHSKAEVPVLEIPQFLVITTKFISKA 2776
            ...||.| |||:.||                     ...|||...            ...|.|..
  Fly  3091 RSSYSSL-PKRHTQS---------------------SLSLHSNGS------------GVSFGSSV 3121

  Fly  2777 DKNMPSK--------VRAKLELLDKSKERDSSK-LTPTATTPTADPTGPSSFSPAPASVGPATQP 2832
            .|..|:.        .:.:.:||.|..:|:|.: ::.|:.....:|.    |...|....||.:|
  Fly  3122 SKRRPAAGGPSAGVLTQFEKQLLHKDLKRNSFRAVSATSKDFVMNPL----FESEPLGEKPALRP 3182

  Fly  2833  2832
              Fly  3183  3182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)2-HP2NP_610972.2 MDN1 <596..845 CDD:227596 79/331 (24%)
PTZ00449 <739..1091 CDD:185628 98/442 (22%)
PTZ00108 <1132..1374 CDD:240271 58/272 (21%)
PTZ00121 <1720..>2291 CDD:173412 124/627 (20%)
CG43340NP_001246184.1 FYVE_BSN_PCLO 63..119 CDD:277290
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1181
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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