DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-HP2 and Leo1

DIOPT Version :9

Sequence 1:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster
Sequence 2:	NP_001005548.1	Gene:	Leo1 / 300837	RGDID:	1549772	Length:	678	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	173/950 - (18%)
Similarity:	315/950 - (33%)	Gaps:	338/950 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GSGSKSQDRRRRPPSPSSSDESNDALEALFCGKSSQSKLSKRRERYESFDSVDDLGEALMRPSHR 132
            ||.::|:..|:...|.|.||...|.      |.|..:......::.|..||
  Rat     9 GSEAESEAERKDSDSGSDSDSDQDN------GASGSNASGSESDQDERGDS-------------- 53

  Fly   133 LTVPKPSTSQA-GSKKSQDAAPHRSISNSSSSNIAMSSGQTYACPKNKKTNSVANKTAVSANGDK 196
               .:||..:. |....::.|||.|.|::.|
  Rat    54 ---GQPSNKELFGDDSEEEGAPHHSGSDNHS---------------------------------- 81

  Fly   197 WASGKNKTVTIVKPQKTDLRPSRLEPKTDPLNLGDLYGDSD-SDSSYEYESDFYGDQDSDEEDEP 260
                          :::|.|....|.::|       :.|:: ||......|:.:.|.|.|::||.
  Rat    82 --------------EQSDNRSEASEERSD-------HEDNEPSDVDQHSGSEAHNDDDDDDDDED 125

  Fly   261 VIDIS--TDTSRTTSVADTVTPVVSDDEGQEPQSELNQ-------RHANDQESFLSSTYERLQSY 316
            ..|..  :|.....|.|:......||||..:.:.:.:|       ::::|:|....|..|:||:
  Rat   126 DDDEGHRSDEGSHHSEAEGSEKAQSDDEKWDGEDKSDQSDDDEKLQNSDDEEREQGSDDEKLQN- 189

  Fly   317 LSNLSSAEPPPIYKKQNSARKSRSNEKKPSSSQQVK--HANEQSAASDKEANKKERDLEP-PEAS 378
                |:.|...:....:..|...|::.:...|::.|  ..:|:.||||.:..|:..|.|. |:.|
  Rat   190 ----SADEEEKMQNTDDEDRAQLSDDDRQQLSEEEKGNSDDERPAASDNDEEKQNSDDEDRPQVS 250

  Fly   379 SSAKSSASKASGSRKLYDVANNATLEAVERMSLDLAEQIMEIDVERSYEFEKRSASKSRSLSRSK 443
            ...|...|         |.......:...|.|.|..||..:.:..|..:.|.......|   ::.
  Rat   251 DEEKMQNS---------DDERPQVSDEDRRHSDDEEEQDQKSESARGSDSEDEVLRMKR---KNA 303

  Fly   444 IPADSSTSQLGHVRKLTYSSERLDQPEPLGTQLRRSKSESLPKRGRPRGQKQRKNRGATME---- 504
            ||:||....              |...|                         |:...||:
  Rat   304 IPSDSEVDS--------------DTEVP-------------------------KDNNGTMDLFGG 329

  Fly   505 -EKSANCRDGE------GEPVKRKRGRPRKIIPKEEAKTAETENTIESLNTNVPLSIDTSKENPE 562
             :..::..|||      |:||. :.|.|:                            |..:|.|.
  Rat   330 ADDISSGSDGEDKPPTPGQPVD-ENGLPQ----------------------------DQQEEEPI 365

  Fly   563 TET-VNLEVPIKQDELVSDLDNAKELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKSESTPK 626
            .|| :.:|:|....:|.:||...|                          .|:.::::.....|:
  Rat   366 PETRIEVEIPKVNTDLGNDLYFVK--------------------------LPNFLSVEPRPFDPQ 404

  Fly   627 VEEEQLCKVDTPSDTALDESKVSESAKNHIELEDKDKDKEETQKESPNGNSKETNENSVIVTNEV 691
            ..|::.          .||..:.|..:..::|                               :|
  Rat   405 YYEDEF----------EDEEMLDEEGRTRLKL-------------------------------KV 428

  Fly   692 ELPAKKAEAKAEAGNIVEESDSQLAEDFKLAEEILAAEVGKGVEANEVSVTSVQGEQNPVIEIVK 756
            |...:....:.|.||.::||::::.   |.::..::..:|.  |..:|....:||:.|.:  .::
  Rat   429 ENTIRWRMRRDEEGNEIKESNARIV---KWSDGSMSLHLGN--EVFDVYKAPLQGDHNHL--FIR 486

  Fly   757 E---LEQETISEVV----PAQNDQSSVEDQT--LADKENPVEK----PSPVKAPSSSKDE--PPA 806
            :   |:.:.:.:..    |...|.::....|  |||:.:..:|    |...:.|...:.|  ...
  Rat   487 QGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILPMAGRDPECQRTEMIKKE 551

  Fly   807 EENLPAPDQDPIEQQKTPVAKNQQH-----------DKEHNEAPKAESLSVSDIPS---SSVTPS 857
            ||.|.|..:...:|::   .:.:||           |:...|....||:|::.|.:   ..:...
  Rat   552 EERLRASIRRESQQRR---MREKQHQRGLSASYLEPDRYDEEEEGEESVSLAAIKNRYKGGIREE 613

  Fly   858 KKRNHSSPANTPKKSKEIEALQSSVPRRALRSDKATPQNLRESRSKRTLKTELTLLMDDTMRRSS 922
            :.|.:||.::        |..:....:|.|::.|.......||..||  |.|     ||.
  Rat   614 RARIYSSDSD--------EGSEEDKAQRLLKAKKLNSDEEGESSGKR--KAE-----DDD----- 658

  Fly   923 PRLGRSPAESHSSHERSPMEKKVTVSKLAKDLITIDKEKE 962
                    :::..|      ||..:|         |:|:|
  Rat   659 --------KANKKH------KKYVIS---------DEEEE 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596	43/274 (16%)
		PTZ00449	<739..1091	CDD:185628	49/252 (19%)
		PTZ00108	<1132..1374	CDD:240271
		PTZ00121	<1720..>2291	CDD:173412
Leo1	NP_001005548.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..373		100/526 (19%)
		PHA02664	<33..183	CDD:177447	38/227 (17%)
		PHA02664	<134..259	CDD:177447	32/138 (23%)
		Leo1	386..544	CDD:281933	32/231 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..596		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..678		21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900