DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Su(var)2-HP2 and Leo1

DIOPT Version :9

Sequence 1:	NP_610972.2	Gene:	Su(var)2-HP2 / 36621	FlyBaseID:	FBgn0026427	Length:	3257	Species:	Drosophila melanogaster
Sequence 2:	NP_001034611.1	Gene:	Leo1 / 235497	MGIID:	2685031	Length:	667	Species:	Mus musculus

Alignment Length:	967	Identity:	173/967 - (17%)
Similarity:	309/967 - (31%)	Gaps:	359/967 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RISSDSSNSSSIDADIFQKLFHGKYLDDELLKEGSGSKS-QDRRRRPPSPSSSDESNDALEALFC 98
            |..|:|.:.|..|.|           :.......|||:| ||.|.....||:.:...|..|..
Mouse    18 RKDSESESDSDSDQD-----------NGASGSNASGSESDQDDRGDSGQPSNKELFGDDSEEE-- 69

  Fly    99 GKSSQSKLSKRRERYESFDSVDDLGEALMRPSHRLTVPKPSTSQAGSK--KSQDAAPHRSISNSS 161
            |.|..|......||      .|:..||..|..|....|......:||:  ...|...|||...|.
Mouse    70 GASHHSGSDNHSER------SDNRSEASERSDHEDNEPSDEDQHSGSEAHNDDDDEGHRSDEGSR 128

  Fly   162 SSNIAMSSGQTYACPKNKKTNSVANKTAVSANGDKWASGKNKTVTIVKPQKTDLRPSRLEPKTDP 226
            .|.   :.|...|                .::.:||..                     |.|:|.
Mouse   129 HSE---AEGSEKA----------------QSDDEKWDG---------------------EDKSDQ 153

  Fly   227 LNLGDLYGDSDSDSSYEYESDFYGDQDSDEEDEPVIDISTDTSRTTSVADTVTPVVSDDEGQEPQ 291
            .:...|....|.|.....:.|...:.|.|||.....|   |..|..         :|||:.|: .
Mouse   154 SDDEKLQNSDDEDREQGSDEDKLQNSDDDEEKMQNTD---DEDRAQ---------ISDDDRQQ-L 205

  Fly   292 SELNQRHANDQESFLSSTYERLQSYLSNLSSAEPPPIYKKQNSARKSRSNEKKPSSSQQVKHAN- 355
            ||..:.:::|:....|...|                  :||||     .:|.:|..|.:.|..|
Mouse   206 SEEEKGNSDDEHPVASDNDE------------------EKQNS-----DDEDQPQVSDEEKMQNS 247

  Fly   356 --EQSAASDKEANKKERDLEPPEASSSAKSSASKASGSRKLYDVANNATLEAVERMSLDLAEQIM 418
              |:...||::..:.:.:.|..:.|.||:.|                           |..::::
Mouse   248 DDERPQVSDEDGRRSDGEEEQDQKSESARGS---------------------------DSEDEVL 285

  Fly   419 EIDVERSYEFEKRSA--SKSRSLSRSKIPADSSTSQ--LGHVRKLTYSSERLDQPEPLGTQLRRS 479
            .:        ::::|  |.|.:.|.:::|.|::.:.  .|....::..|:..|:|...|
Mouse   286 RL--------KRKNAIPSDSEADSDTEVPKDNNGTMDLFGGADDISSGSDGEDKPPTPG------ 336

  Fly   480 KSESLPKRGRPRGQKQRKNRGATMEEKSANCRDGEGEPVKRKRGRPRKIIPKEEAKTAETENTIE 544
              :.:.:.|.|:.|:                   |.||:
Mouse   337 --QPVDENGLPQDQQ-------------------EEEPI-------------------------- 354

  Fly   545 SLNTNVPLSIDTSKENPETETVNLEVPIKQDELVSDLDNAKELTGSTNLPQDDIEMASNHQETDL 609
                            |||. :.:|:|....:|.:||...|
Mouse   355 ----------------PETR-IEVEIPKVNTDLGNDLYFVK------------------------ 378

  Fly   610 KCAPDRVALDKSESTPKVEEEQLCKVDTPSDTALDESKVSESAKNHIELEDKDKDKEETQKESPN 674
              .|:.::::.....|:..|::.          .||..:.|..:..::|:.::..:...:::...
Mouse   379 --LPNFLSVEPRPFDPQYYEDEF----------EDEEMLDEEGRTRLKLKVENTIRWRIRRDEEG 431

  Fly   675 GNSKETNENSVIVTNEVELPAKKAEAKAEAGNIVEESDSQLAEDFKLAEEILAAEVGKGVEANEV 739
            ...||:|                       ..||:.||..::             :..|.|..:|
Mouse   432 NEIKESN-----------------------ARIVKWSDGSMS-------------LHLGNEVFDV 460

  Fly   740 SVTSVQGEQNPVIEIVKE---LEQETISEVV----PAQNDQSSVEDQT--LADKENPVEK----P 791
            ....:||:.|.:  .:::   |:.:.:.:..    |...|.::....|  |||:.:..:|    |
Mouse   461 YKAPLQGDHNHL--FIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRCSKTQKIRILP 523

  Fly   792 SPVKAPSSSKDE--PPAEENLPAPDQDPIEQQKTPVAKNQQH-----------DKEHNEAPKAES 843
            ...:.|...:.|  ...||.|.|..:...:|::   .:.:||           |:...|....||
Mouse   524 MAGRDPECQRTEMIKKEEERLRASIRRESQQRR---MREKQHQRGLSASYLEPDRYDEEEEGEES 585

  Fly   844 LSVSDIPS---SSVTPSKKRNHSSPANTPKKSKEIEALQSSVPRRALRSDKATPQNLRESRSKRT 905
            :|::.|.:   ..:...:.|.:||.::        |..:....:|.|::.|.......||..||
Mouse   586 VSLAAIKNRYKGGIREERARIYSSDSD--------EGSEEDKAQRLLKAKKLNSDEEGESSGKR- 641

  Fly   906 LKTELTLLMDDTMRRSSPRLGRSPAESHSSHERSPMEKKVTVSKLAKDLITIDKEKE 962
             |.|     ||.             :::..|      ||..:|         |:|:|
Mouse   642 -KAE-----DDD-------------KANKKH------KKYVIS---------DEEEE 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Su(var)2-HP2	NP_610972.2	MDN1	<596..845	CDD:227596	42/274 (15%)
		PTZ00449	<739..1091	CDD:185628	50/253 (20%)
		PTZ00108	<1132..1374	CDD:240271
		PTZ00121	<1720..>2291	CDD:173412
Leo1	NP_001034611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..362		101/543 (19%)
		PHA02664	<61..209	CDD:177447	45/208 (22%)
		Leo1	375..533	CDD:281933	31/231 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..585		5/39 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..667		22/106 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900