DRSC/TRiP Functional Genomics Resources

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Protein Alignment Su(var)2-HP2 and Rp1

DIOPT Version :9

Sequence 1:NP_610972.2 Gene:Su(var)2-HP2 / 36621 FlyBaseID:FBgn0026427 Length:3257 Species:Drosophila melanogaster
Sequence 2:NP_035413.1 Gene:Rp1 / 19888 MGIID:1341105 Length:2095 Species:Mus musculus


Alignment Length:2136 Identity:392/2136 - (18%)
Similarity:717/2136 - (33%) Gaps:564/2136 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   269 SRTTSVADTVTPVVSDDEGQEPQSELNQRHAN-------DQESFLSS---------------TYE 311
            |.|.|.:.::..:.|  |||.|    :.||:|       .:.||..|               :::
Mouse     2 SDTPSTSFSMIHLTS--EGQVP----SPRHSNITHPVVAKRISFYKSGDPQFGGVRVVVNPRSFK 60

  Fly   312 RLQSYLSNLSSAEPPPIYKKQNSARKSRSN-----EKKPSSSQQVKHANEQSAASDKEANKKER- 370
            ...:.|.:||...|.|...:..|..:.|.:     |.:...|....|..:.......:|.::.| 
Mouse    61 TFDALLDSLSRKVPLPFGVRNISTPRGRHSITRLEELEDGKSYVCSHNKKVLPVDLDKARRRPRP 125

  Fly   371 -----------DLEPPEASSSAKSSASKASGSRKLY----DVANNATLEAVERMS------LDLA 414
                       .|.|..|:.|..:.....:..|.:.    |..|...:....|::      |...
Mouse   126 WLSSRSISTHVQLCPATANMSTMAPGMLRAPRRLVVFRNGDPKNKHVVLLSRRITQSFEAFLQYL 190

  Fly   415 EQIMEIDVERSYEFEKRSASKSRSL---SRSKIPADSSTSQLGHV--------RKLTYSSERLDQ 468
            .|:|:..|.:.|..:.|.....:::   |.:.:.|.....:.|:.        .||...|.|:.|
Mouse   191 TQVMQCPVAKLYATDGRKVPSLQAVILSSGAVVAAGREPFKPGNYDIQKYLLPAKLPGISHRVHQ 255

  Fly   469 PEPLGTQLRRSKSESLPKRGRPRGQKQRKNRGATMEEKSANC-RDGEGEPVKRKRGRPRKIIPKE 532
            ......: :|..|..:|...||:       ..:.:.||:.:| .|....|              |
Mouse   256 KGKAKIE-KRKMSTHMPSDLRPQ-------TDSLISEKTYDCFSDFSVAP--------------E 298

  Fly   533 EAKTAETENTIESLNT-----NVPLSIDTSKENPETETVNLEVPIKQDELV-------------S 579
            .....||..: :||:|     :|..||..:::...|..:.:...||::|.|             :
Mouse   299 NYLALETHES-QSLSTYPSEDDVEKSIVFNQDGTMTVVMKVRFKIKEEETVKWTTTVNRAGLSNN 362

  Fly   580 DLDNAK-ELTGSTNLPQDDIEMASNHQETDLKCAPDRVALDKSESTPKVEEEQLCKVDTPSDTAL 643
            |..|.| ...|.|:.....:::.:.....|:.....:.:|.:.|:|...|::.|.......:.|.
Mouse   363 DEKNKKSSYPGKTDYGPSSLKLEACSLPEDIVDTTQQGSLTEEENTQMTEQQALSCSSASWENAS 427

  Fly   644 DESKVSESAK--NHIELEDKDKDKEETQKESPNGNSKETNENSVIVTNEVELPAKKAEAKAEAGN 706
            .|:.:.||.|  .|.........:...||:|..|        :|.|.:|.|:..|:         
Mouse   428 METDIQESQKQVKHFYRPPTPGPRRMRQKKSVIG--------TVTVVSETEVQEKQ--------- 475

  Fly   707 IVEESDSQLAEDFKLAEEILAAEVGKGVEANEV-----SVTSVQGEQNPVIEIVKELEQETISEV 766
                        |..:||      .||.|.:|.     |.:.:....|.:::|..:.|.|:..| 
Mouse   476 ------------FSYSEE------RKGGEKSEYHMFTHSCSKMSSVSNKLVQIGSDNEMESALE- 521

  Fly   767 VPAQNDQSSVEDQTLADKENPVEKPSPVK------APSSSKDEPPAEENLP-------------- 811
              ...:..|::.|.:......:.....:|      .||::.:....||...              
Mouse   522 --RTRESGSLKSQAINAGAIEITSQKVLKMCHNNALPSTAPENSVVEEGTDNSAVSGTATIKHFR 584

  Fly   812 ----APDQ-DPIEQQKTPVA-KNQQHDKEHNEAPKAESLSVSDIPSSSVTPSKKRNHSSPANTPK 870
                |.|. ..|....||.: .|..:|:..:|.|...|      |..::....:..|......|:
Mouse   585 TCGNANDSFSSITADSTPTSVNNYSNDRNISELPSVGS------PVLTMRLVNEFAHCGLTEKPE 643

  Fly   871 KSKEIEALQSSVPRRALRSDKATPQNLRESRSKRTLKTELTLLMDDTMRRSSPRL-GRSPAESHS 934
            ..|::  |.||..::  :..|:..:.:..:..|:.::|           :..|.: |:.|....:
Mouse   644 NRKKV--LSSSASKK--KKKKSQQRMITSNDKKKVIET-----------KGPPNIAGKIPRAGTT 693

  Fly   935 SHER------------SPMEKKVTVSKLAKDLITIDKEKEIELKS-LPDASETKDVKITKTTTAS 986
            :.||            ...|:.:.:|.:|           ||..: .|.::.|......|     
Mouse   694 AQERLLQESDCPDKGGRVCEQGLNISPMA-----------IESNNFFPKSNPTFSKNFYK----- 742

  Fly   987 DTSILTDENPSSSKTEMKKLKGKPLKAKKMSRTSETEVKKAIADSNEDIPSIFS-IKCVEEHLTS 1050
             ..:.|.:||.:.|. :.|.|.:|.|.....|..:.|:      ..||...:.| .|..|.||..
Mouse   743 -NKLNTFQNPKTQKL-LAKRKSRPRKIVSTERLRKQEI------GQEDKILLHSDSKLCESHLEK 799

  Fly  1051 S---------ESEQKDEKEELLCPKPQIDCTNTDLEQSTAIETDTEQVEEKRSNRRKSRRIRNEK 1106
            .         |.:||    .|..|..|::....:| :..|.::...:|.:.....|..::....|
Mouse   800 QSLFHVFNILEEDQK----VLHRPPFQVEKVARNL-KGMAKKSLVPKVNDLHIMLRNQKKQMGVK 859

  Fly  1107 FKTETDTLSDHLDAKKAENASLEISMRPKCTLETQQSDPVTAKNKRNSGRLSRKEKSVINAAKSE 1171
            .|:..:....|:                     |.::||:                     |..:
Mouse   860 LKSGAEVSEQHV---------------------TTRADPL---------------------ASLK 882

  Fly  1172 KDKSPSAISQSTERK------QLLNENPSKKDKKTEQSGNKKEAVVGPLDKTETSSSTNIIDKKS 1230
            |...|..|...:.:.      |.:|..|..:.:|:           |||    ..:.:::::...
Mouse   883 KPDFPEGIPHHSGKSYVKRWLQNINSYPDFEHRKS-----------GPL----CQNRSDVVNYNR 932

  Fly  1231 NESFDSAMQPSDRLNQKESAFTKLSSISSPKKIMKDQDKDLDALSKGGDSNPTIRDTGEDSRQTD 1295
            |....:.:..:   :.|.:.|...|:.|..|.         |..|  |::|   ::||:.....|
Mouse   933 NGFLGNNLHTT---SSKGNGFLMESNKSKTKN---------DNWS--GNTN---QETGKSLVAKD 980

  Fly  1296 KKHQENDTKHEEEDSSKLKANIDETKSSSEKDAEPISKDS-SQDSAKPRLSKPKSRNKRKKNEKK 1359
            ...:.|  ||..|..:   .::.::...|..|...:|:.: ::.|.|..||..|||.:.|...::
Mouse   981 NGEELN--KHHCESQN---GSLYDSYLVSLHDNCTLSQTTINEPSTKSHLSIEKSRPEVKLVYQE 1040

  Fly  1360 PNDSIAESDIEGGFQVNTETVQATCSTPSESNKKDMVKSDETNEEPNLSETEIGRIRKRGQAFHI 1424
            .|.:.....||...||:         |..|:..||.:        |.|       :.:..:||..
Mouse  1041 MNFATKRQSIEVAIQVD---------TMGENVLKDYL--------PAL-------LLRHLEAFVP 1081

  Fly  1425 ENPKDDLHITPQNENQSIAGVNFEKQVPLPESVESDTP--------IMKIPTKTYLMCTKNKTSL 1481
            .|.|.      ||....|.|...|  |..|..:::.:.        ::.:.......|..:...:
Mouse  1082 NNQKH------QNGISQIPGSLAE--VVFPSVIDNSSTNLLLAWLLVLNLKRTMNSFCQSDAHKM 1138

  Fly  1482 LSASEDPDIVLEPQKLIT--------------------TSKGDSNPDLD----NANNLETSSTQD 1522
            .:...:...:||..|.:.                    |..|.|..:.|    |.......|..:
Mouse  1139 TNRPSETAALLEVLKHVAITEEADDLKAAVANLMESTKTCSGSSGREQDMLPVNCTASSLHSVDE 1203

  Fly  1523 PKEHEFSDQTFTDNS-DIIPSCTK-----------KSQIVFPTTPTKSSDQTKNSFITPNRSPKS 1575
            ..|:..:.:|..|.. .::..||.           :..:|..|.|.|..|...:..:|.|....|
Mouse  1204 CNENGSAQKTLLDEGYSVMGDCTSEMVSKSCNSSCEMHMVSKTNPPKQVDDQSDGLLTSNSCTVS 1268

  Fly  1576 KRNVSKEAKRLDNSFEESQNAASES--SASKVQKELRTPTASCRKLRVLIKRTP--TSSLPTNSR 1636
            :|:.. .....|..:.....|..|.  ..:.:..|...|...|..:..:..:..  |..|.:...
Mouse  1269 QRSTG-ACFLTDGVYSHEACAQKEGVYEGACLSDETHIPIRDCHTIHSVHSKENKCTDDLESTEE 1332

  Fly  1637 KSIFKKTPAKSKRLTKILESMEKTPSREPSVSLGEVNPDSDPVAAESVAVLHESDRDL----ESN 1697
            .....|.|   |.|:.:.:||.|..|...:..  .||..|......|...| :||:|.    |..
Mouse  1333 LKTVDKVP---KGLSILADSMYKNDSNVSTFQ--NVNKLSSQRTLLSKTYL-DSDKDYSPLEEFQ 1391

  Fly  1698 EIPNEEVFEDTEEASAEDTDNKLKKKEDDHELEVNDICAASKNPITD-DSTKDASS--------- 1752
            ..|.:::....:..|::..::  :..|:...: .|.:.::.:|.|:: :|.::..|         
Mouse  1392 NCPRKKIVNKKKSISSDKEES--RTSEEPRSI-TNSMTSSERNAISELESFEELESQDTSIFNMN 1453

  Fly  1753 ----NKSTDSDVLQETKDELSNSLINATQGEDTPIKELTEEEVPNNKTVEDESKKQEILKDLEPD 1813
                .|||...:.::::..:|:.|||                |...|.:|.|.:           
Mouse  1454 VRAEKKSTKETMQKQSEARMSSELIN----------------VSGRKIIEQERR----------- 1491

  Fly  1814 NAALEEDTASTAKAAEEMDLYIKEKSNVKSVLAEPET--------DVTDDEELAQSPI------- 1863
            |.|:.|.||........:........|.:..::|.||        |..::|..::|.:       
Mouse  1492 NTAILETTARGQVTPPSLAFCYDSNKNTEKEISEGETKMRVKKMVDSMENESYSESSLNFKKHHR 1556

  Fly  1864 -PNSSETTSVTDDPEPSTSSVVKRSLRKREADSSQPDEAAKRKQRQDVEKSLTGKKEQVKP---- 1923
             |.:.:.:....|.|  :....|.|......||.|..|..:...::.:|| |.||.|.:||    
Mouse  1557 SPGTLDWSDYGSDSE--SGYPCKASSNSHNDDSGQEKEPTRGIVKRAIEK-LYGKAEIIKPPFFH 1618

  Fly  1924 --ARRRQLA---EVEERPSLKRSKTESEAKSTVQGKYI---SIIGNETIMSSTTAPIRETNREAA 1980
              ..:.|:.   .||.:.:.|.:..|||.:|.|..:.:   |:|..|       .|..:.|....
Mouse  1619 GSIHKSQVCPYNSVEVQCAKKTNFYESECQSLVSSEQVSRSSLIFQE-------FPQVDANGMGD 1676

  Fly  1981 STSPSARKSAVQEAKH--VETTKH---IILGPPGKKLLH--------SDSPA--AEVKKPMVQTL 2030
            |...|:.::..:.:.|  |.|.|.   :|  ..||.||.        ||:|.  .......|.||
Mouse  1677 SFGDSSIENVTKSSAHDRVFTEKENGKLI--DNGKWLLRENHLWRVSSDNPGMYGNADTTSVDTL 1739

  Fly  2031 LSSTLSLQKP------------------STLDD-GSPLKIR--------KSLKKSIADENIDGDQ 2068
            :... |::.|                  |.::: ..||:::        .|..:...::..|...
Mouse  1740 IDKN-SIEVPYSHFGELAPGPTMAELSSSEIEEMTQPLEVKCNYFNFPHGSDSEPFGEDFPDAQN 1803

  Fly  2069 SIFSSSSVLNKNTSVVAPRKVNISVSLLQSKDTQVETAASSSETPILTKKEKLKTQ 2124
            .......:.|.:|.    .|.|.....|.:..||...:|.:...|:.:  :.:|||
Mouse  1804 KTCPKEKIPNHHTE----EKGNYPSERLCTSVTQAFVSAGNKVHPVCS--DAIKTQ 1853

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Su(var)2-HP2NP_610972.2 MDN1 <596..845 CDD:227596 51/281 (18%)
PTZ00449 <739..1091 CDD:185628 72/406 (18%)
PTZ00108 <1132..1374 CDD:240271 45/248 (18%)
PTZ00121 <1720..>2291 CDD:173412 96/489 (20%)
Rp1NP_035413.1 DCX 35..110 CDD:176357 13/74 (18%)
DCX 157..232 CDD:176357 12/74 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..379 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..688 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..887 6/65 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1400..1430 3/32 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1572..1595 6/22 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1181
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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