DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tra2 and HNRNPDL

DIOPT Version :9

Sequence 1:	NP_476764.1	Gene:	tra2 / 36619	FlyBaseID:	FBgn0003742	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_112740.1	Gene:	HNRNPDL / 9987	HGNCID:	5037	Length:	420	Species:	Homo sapiens

Alignment Length:	358	Identity:	70/358 - (19%)
Similarity:	113/358 - (31%)	Gaps:	155/358 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSGRLHCSARYKH--KRSASSSSAGTTSSGHKDRRSDYDYCGSRRHQRSSSRRRS-----RSRSS 64
            ||.|.......:|  .:..|..:.|....|.:.||.|.    .|||.:|||.:||     .:|::
Human    48 SSARQGARRAQRHVTAQQPSRLAGGAAIKGGRRRRPDL----FRRHFKSSSIQRSAAAAAATRTA 108

  Fly    65 SESPPPE--------------------PRHRSGRSSRDRERMH---------------------- 87
            .:.||.:                    .:..:.::.:|..:|.
Human   109 RQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDDGKMFIGGLSWDTSKKDLTEYLSRFGE 173

  Fly    88 -------------KSR--------------------EH--------PQASRC---------IGVF 102
                         :||                    ||        |:.::.         :.|.
Human   174 VVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVG 238

  Fly   103 GLNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYF------EKLSDARAAKDSCSGI 161
            ||:.:||:.:::|.|..:|.||.|::.:|.:|...||||||.:      :||.::|..:......
Human   239 GLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFCFITYTDEEPVKKLLESRYHQIGSGKC 303

  Fly   162 EVDGRRIRVDFSITQRAHTPTPGVYLGRQP-----RGKAPRSFSPRRGR------------RVYH 209
            |:         .:.|...     ||..:|.     ||.|.......|||            ..|:
Human   304 EI---------KVAQPKE-----VYRQQQQQQKGGRGAAAGGRGGTRGRGRGQGQNWNQGFNNYY 354

  Fly   210 DRSASPYDNYRDR------------YDYRNDRY 230
            |:.   |.||...            |||....|
Human   355 DQG---YGNYNSAYGGDQNYSGYGGYDYTGYNY 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tra2	NP_476764.1	RRM	<74..242	CDD:223796	49/264 (19%)
tra2	NP_476764.1	RRM_TRA2	98..175	CDD:240809	23/91 (25%)
HNRNPDL	NP_112740.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..120		5/23 (22%)
		RRM1_hnRPDL	149..224	CDD:410152	6/74 (8%)
		RRM2_hnRPDL	234..308	CDD:409998	23/82 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..348		9/34 (26%)
		Necessary for interaction with TNPO1. /evidence=ECO:0000269\|PubMed:9524220	342..420		9/46 (20%)
		Necessary for its nuclear import and export	396..420
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..420
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910