Protein Alignment tra2 and PABPN1

DIOPT Version :10

• Sequence 1: NP_476764.1
• Gene: tra2 / 36619
• FlyBaseID: FBgn0003742
• Length: 264
• Species: Drosophila melanogaster
• Sequence 2: NP_004634.1
• Gene: PABPN1 / 8106
• HGNCID: 8565
• Length: 306
• Species: Homo sapiens
• Alignment Length: 180
• Identity: 44/180 - (24%)
• Similarity: 71/180 - (39%)
• Gaps: 53/180 - (29%)

  Fly    67 SPPPEPRHRSGRSS----RDRERMHKSREHPQASRCIGVFGLNTNTSQHKVRELFNKYGPIERIQ 127
            ||||      |.:.    ...|:|...      :|.|.|..::...:..::...|:..|.:.|:.
Human   150 SPPP------GNAGPVIMSIEEKMEAD------ARSIYVGNVDYGATAEELEAHFHGCGSVNRVT 202

  Fly   128 MVIDAQTQRSRGFCFIYFEKLSDARAAKDSCSGIEVD-----GRRIRVDFSITQRAHTPTPGV-- 185
            ::.|..:...:||.:|.|   ||..:.:.|   :.:|     ||:|:|   |.:|  |..||:
Human   203 ILCDKFSGHPKGFAYIEF---SDKESVRTS---LALDESLFRGRQIKV---IPKR--TNRPGIST 256

  Fly   186 ---------YLGRQPRGKAPRS-----FSPRRGRRVYHDRSA-----SPY 216
                     |..|.....:.||     |:.|...|||..|:.     |||
Human   257 TDRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGRVYRGRARATSWYSPY 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tra2	NP_476764.1	RRM_TRA2	96..175	CDD:409798	19/83 (23%)
PABPN1	NP_004634.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..115
		Interaction with SKIP. /evidence=ECO:0000269|PubMed:11371506	2..145
		GCG-encoded polyalanine repeat	2..7
		Stimulates PAPOLA. /evidence=ECO:0000250	119..147
		Necessary for homooligomerization	155..306		37/167 (22%)
		RRM_II_PABPN1	173..248	CDD:409966	19/83 (23%)
		Interaction with PAPOLA. /evidence=ECO:0000250	286..306		6/19 (32%)