DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tra2 and SAFB

DIOPT Version :9

Sequence 1:	NP_476764.1	Gene:	tra2 / 36619	FlyBaseID:	FBgn0003742	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_001188267.1	Gene:	SAFB / 6294	HGNCID:	10520	Length:	917	Species:	Homo sapiens

Alignment Length:	225	Identity:	50/225 - (22%)
Similarity:	92/225 - (40%)	Gaps:	24/225 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 RRSDYDYCGSRRHQRSSSRRRSRSRSSSESPPPEPRHRSGRSSRDRERMHKSREHPQASRC---I 99
            |:.|:|.|         :......:.||.|...:.:..|.....|.:|:  |:|....|.|   .
Human   355 RKFDFDAC---------NEVPPAPKESSTSEGADQKMSSPEDDSDTKRL--SKEEKGRSSCGRNF 408

  Fly   100 GVFGLNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYFEKLSDARAAKDSCSGIEVD 164
            .|.||::.|....::.||:|||.:...::|.:|::..:|.:.|:......:|....:.....|:.
Human   409 WVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELH 473

  Fly   165 GRRIRVDFSITQRAHTPTPGVYLGRQPRGKAPRSFSPRRGRRVYHDRSASPYDNYRDRYD----Y 225
            |:.|.|:.:..:.....|..   .|...||..:|.:..|...:..|......|:.:...|    .
Human   474 GKMISVEKAKNEPVGKKTSD---KRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEK 535

  Fly   226 RNDRYDRNLRRSPS-RNRYTRNRSYSRSRS 254
            ..|:.|:  :..|| |:|.|::.|....|:
Human   536 SKDQDDQ--KPGPSERSRATKSGSRGTERT 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tra2	NP_476764.1	RRM	<74..242	CDD:223796	39/175 (22%)
tra2	NP_476764.1	RRM_TRA2	98..175	CDD:240809	19/79 (24%)
SAFB	NP_001188267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SAP	31..65	CDD:128789
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..407		14/62 (23%)
		RRM_SAFB1_SAFB2	405..480	CDD:241123	17/74 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..641		20/92 (22%)
		Interaction with POLR2A. Interaction with SFRS1, SFRS9 and SFRS10. /evidence=ECO:0000250\|UniProtKB:O88453, ECO:0000269\|PubMed:9671816	528..792		10/38 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	599..616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1765
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940