DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tra2 and NCL

DIOPT Version :9

Sequence 1:	NP_476764.1	Gene:	tra2 / 36619	FlyBaseID:	FBgn0003742	Length:	264	Species:	Drosophila melanogaster
Sequence 2:	NP_005372.2	Gene:	NCL / 4691	HGNCID:	7667	Length:	710	Species:	Homo sapiens

Alignment Length:	189	Identity:	43/189 - (22%)
Similarity:	80/189 - (42%)	Gaps:	44/189 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KHKRSASSSSAGTTSSGHKDRRSDYDYCGSRRHQRSSSRRRSRSRSSSESPPPEPRHRSGRSSRD 82
            :::...|...|....:..:|.:...:.|..|..:..:      .|...:.|...|..||
Human   516 QNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRA------IRLELQGPRGSPNARS------ 568

  Fly    83 RERMHKSREHPQASRCIGVFGLNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYFEK 147
                       |.|:.:.|.||:.:|::..::|.|:  |.: |.::|.|.:|..|:||.|:.|..
Human   569 -----------QPSKTLFVKGLSEDTTEETLKESFD--GSV-RARIVTDRETGSSKGFGFVDFNS 619

  Fly   148 LSDARAAKDSCSGIEVDGRRIRVDFSITQRAHTPTPGVYLGRQPRGKAPRSFSPRRGRR 206
            ..||:|||::....|:||.::.:|::                :|:|:.  .|..|.|.|
Human   620 EEDAKAAKEAMEDGEIDGNKVTLDWA----------------KPKGEG--GFGGRGGGR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tra2	NP_476764.1	RRM	<74..242	CDD:223796	35/133 (26%)
tra2	NP_476764.1	RRM_TRA2	98..175	CDD:240809	25/76 (33%)
NCL	NP_005372.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..303
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	307..381	CDD:240849
		RRM	379..628	CDD:223796	32/137 (23%)
		RRM2_NCL	390..465	CDD:240850
		RRM3_NCL	485..557	CDD:240851	6/46 (13%)
		RRM4_NCL	572..649	CDD:240852	26/95 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..710		7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48034
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100