DRSC/TRiP Functional Genomics Resources

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Protein Alignment tra2 and Safb

DIOPT Version :9

Sequence 1:NP_476764.1 Gene:tra2 / 36619 FlyBaseID:FBgn0003742 Length:264 Species:Drosophila melanogaster
Sequence 2:NP_001361548.1 Gene:Safb / 224903 MGIID:2146974 Length:939 Species:Mus musculus


Alignment Length:315 Identity:73/315 - (23%)
Similarity:108/315 - (34%) Gaps:92/315 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DREPLSSGRLHCSARYKHKRSASSSSAGT-----------------TSSGHKDRRS-DYDYCGSR 48
            |::|..|.|         .|:..|.|.||                 .:||.|:|.| ..|...:.
Mouse   563 DQKPGPSER---------SRTTKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSAS 618

  Fly    49 RHQRS--SSRRRSRSRSSSESPPPEPRHRSGRSSR--------DRERMHKSREHPQASRCIGVFG 103
            |.:||  |..:...||.|.:|.....|.||.|..|        :|||:..:||.....|      
Mouse   619 REKRSVVSFDKVKESRKSRDSESRRERERSEREQRLQAQWEREERERLEIARERLAFHR------ 677

  Fly   104 LNTNTSQHKVRELFNKYGPIERIQMVIDAQTQRSRGFCFIYFEKL---SDARAAKDSCSGI---- 161
                   |::.....:...:||.:|.::.:.:|.:.......|:|   .:.|..::....:    
Mouse   678 -------HRLERERMERERLERERMHVEQERRREQERIHREREELRRQQELRYEQERRPAVRRPY 735

  Fly   162 EVDGR----------------RIRVDFSITQRAHTPTPGVYLGRQPRGKAPRSFSPRR--GRRVY 208
            |||||                |...|||...|.|.      ...:.||:.|.....||  .|.:.
Mouse   736 EVDGRRDDAYWPEAKRAALDDRYHSDFSRQDRFHD------FDHRDRGRYPNHSVDRREGSRSMM 794

  Fly   209 HDRSASPYDNYRDRYDYRNDRYDRNLRRSPSRNRYTRNRSYSRSRS----PQLRR 259
            .||..       ..|..|:...:|:.|.|.....|..|:..|..|.    |:.||
Mouse   795 GDREG-------QHYPERHGGPERHGRDSRDGWGYGSNKRLSEGRGLPPPPRGRR 842

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tra2NP_476764.1 RRM <74..242 CDD:223796 42/200 (21%)
RRM_TRA2 98..175 CDD:240809 17/99 (17%)
SafbNP_001361548.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
SAP 31..65 CDD:128789
PLN03124 32..>183 CDD:215591
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 64..117
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 222..429
RRM 368..>527 CDD:223796
RRM_SAFB1_SAFB2 427..502 CDD:241123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 499..661 28/106 (26%)
Interaction with POLR2A, SFRS1, SFRS9 and SFRS10. /evidence=ECO:0000250|UniProtKB:O88453 550..814 64/285 (22%)
Nuclear localization signal. /evidence=ECO:0000255 621..638 6/16 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 684..738 8/53 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1765
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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