DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpI1 and RPA190

DIOPT Version :9

Sequence 1:	NP_523743.1	Gene:	RpI1 / 36617	FlyBaseID:	FBgn0019938	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_014986.3	Gene:	RPA190 / 854519	SGDID:	S000005868	Length:	1664	Species:	Saccharomyces cerevisiae

Alignment Length:	1790	Identity:	631/1790 - (35%)
Similarity:	937/1790 - (52%)	Gaps:	303/1790 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTC-LKLQDCPG 77
            :.::|.:.|.:|||.||..::......|.|||.:.|||||:.:|::.|.:  |.|| |..:.|||
Yeast    12 TSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLYDLALGAFLRNL--CSTCGLDEKFCPG 74

  Fly    78 HMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHE-----CEIIMLQLRLIDAGY----- 132
            |.|||||..|.|||.|...:...|...||.|:..::|..|     |::.:||..|||..|
Yeast    75 HQGHIELPVPCYNPLFFNQLYIYLRASCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEI 139

  Fly   133 --------------IIEAQELEL-----FKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNE 178
                          .||..|.|:     .:|:.:.....|.:..|..:.|...||   |.|....
Yeast   140 TLGSLNSSMYTDDEAIEDNEDEMDGEGSKQSKDISSTLLNELKSKRSEYVDMAIA---KALSDGR 201

  Fly   179 KNSSNS-TKTSCSLRTAITHSALQRL--GKKCRHCNK-SMRF---------------VRYMHRRL 224
            .....| |.|....|..:.|...::|  ..||.:|.. |.:|               .:..:.|:
Yeast   202 TTERGSFTATVNDERKKLVHEFHKKLLSRGKCDNCGMFSPKFRKDGFTKIFETALNEKQITNNRV 266

  Fly   225 VFYVTLADIKER---------------------VG----TGAETGGQ-----------NKVIFAD 253
            ..::....||::                     ||    |..:||..           :.|...:
Yeast   267 KGFIRQDMIKKQKQAKKLDGSNEASANDEESFDVGRNPTTRPKTGSTYILSTEVKNILDTVFRKE 331

  Fly   254 ECRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLK 318
            :|  .|:.::.:.|.|.:.||                ..|.||||.|.|.|.|.|..:.:|:.:.
Yeast   332 QC--VLQYVFHSRPNLSRKLV----------------KADSFFMDVLVVPPTRFRLPSKLGEEVH 378

  Fly   319 GNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDV 383
            .|.|..:...::    ..:::::.:.....||.:: |.:.:..:  ....:|..|::.:|..|:.
Yeast   379 ENSQNQLLSKVL----TTSLLIRDLNDDLSKLQKD-KVSLEDRR--VIFSRLMNAFVTIQNDVNA 436

  Fly   384 LLDVNMSREMKSGE----GLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIF 444
            .:|...::...||:    |:||.:|||.||.|.||||||||||||:||:|||||..:|||:|.:|
Yeast   437 FIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKHMMGKRVNYAARSVISPDPNIETNEIGVPPVF 501

  Fly   445 AKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAKLLLSNPK 509
            |.||:||.|||.:|:.|||:.|:||||..|||..||:::|....:...:..:|::||..||: |.
Yeast   502 AVKLTYPEPVTAYNIAELRQAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLT-PS 565

  Fly   510 DGI------KIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDG 568
            ..:      |.|:||:.|.||:|:||||:|||.|:||||.|:|..|||.||||:|..||||||||
Yeast   566 SNVSTHTLNKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYANTGAYNADFDG 630

  Fly   569 DEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQL 633
            ||||.|:||:|.|||||.||.|..|.||.|..|:|:.||||||:.:||.|:.:..||.||.|||.
Yeast   631 DEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLIQDHISAGVWLTSKDSFFTREQYQQY 695

  Fly   634 VF------QGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGKN 692
            ::      .|.:...| |..|||||.||..||:||||::|:::|:.|.....|||.|..||..:.
Yeast   696 IYGCIRPEDGHTTRSK-IVTLPPTIFKPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEY 759

  Fly   693 WNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTLL 757
            |               |....|::|..::|.||.|:|||.||||:.||::|.::|:||.:|:..:
Yeast   760 W---------------GKGSLENEVLFKDGALLCGILDKSQYGASKYGIVHSLHEVYGPEVAAKV 809

  Fly   758 LTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPPHD--E 820
            |:...::||.::....||.|:.|:.:|...::.|..|::...:.|..|.|....|:.:.|.|  |
Yeast   810 LSVLGRLFTNYITATAFTCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPADDPE 874

  Fly   821 LVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSGAKGSMV 885
            |::::: ..::|:....:||....|.::..|:.:.|.|:|.|.:.|||.|::|.|.|||||||.|
Yeast   875 LLKRLQ-EILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKFPCNSMQAMALSGAKGSNV 938

  Fly   886 NTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQDFFFHCMAGR 950
            |..||.|||||..|||:|.|:|:|||:||||..:||...:||::.|||.:||:||:::|||||||
Yeast   939 NVSQIMCLLGQQALEGRRVPVMVSGKTLPSFKPYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGR 1003

  Fly   951 EGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDILKSKFFND-KF 1014
            ||||||||||||||||||||.|.|||:.|.||.::||:|.::|||:||.|.:||.|...... :|
Yeast  1004 EGLIDTAVKTSRSGYLQRCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEF 1068

  Fly  1015 CADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPAKLRAAFTHFSEELREEVEV 1079
            |.|    |..|:|:                           |..|:           .|.|.::|
Yeast  1069 CLD----NYYALLK---------------------------KYNPS-----------ALIEHLDV 1091

  Fly  1080 KRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCP--------DPTVAVYKQDLYYGS 1136
                            |..||..||.     ..||||:::.|        ||.:|.|....|.||
Yeast  1092 ----------------ESALKYSKKT-----LKYRKKHSKEPHYKQSVKYDPVLAKYNPAKYLGS 1135

  Fly  1137 VSERTRKLITDYAKRKPAL--------KETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQM 1193
            |||..:..:..:..:...|        ::....:|::|.::||..|||.||:||:||:|||||||
Yeast  1136 VSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALMQLKYMRSLINPGEAVGIIASQSVGEPSTQM 1200

  Fly  1194 TLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPI-KPGQQHQAEKLRINLNSVTLAN 1257
            |||||||||.|..||||||||||||:|.||:.||||.|.:|| ......||:....:::.|.|:.
Yeast  1201 TLNTFHFAGHGAANVTLGIPRLREIVMTASAAIKTPQMTLPIWNDVSDEQADTFCKSISKVLLSE 1265

  Fly  1258 LLEYVHV--STGLTL----DPERSYEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQTFFKQLIRA 1316
            :::.|.|  :||.:.    :..|||...||  |.....|.|:|.|..:.:...:...|...|..|
Yeast  1266 VIDKVIVTETTGTSNTAGGNAARSYVIHMR--FFDNNEYSEEYDVSKEELQNVISNQFIHLLEAA 1328

  Fly  1317 ILK-VSNASRTTKIVVIDDKKDADKEDDNDLDNGDEVGRSKAK-----ANDDDSS----DDNDDD 1371
            |:| :....|||                     |.::|.:..:     ||...:|    :|||::
Yeast  1329 IVKEIKKQKRTT---------------------GPDIGVAVPRLQTDVANSSSNSKRLEEDNDEE 1372

  Fly  1372 DATGVKLKQRKTDEK-DYDDP--DDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGD-----DKA 1428
            .:      .:||.:. .||:|  |::|.:.:|....||...:.|:|...|..|.|.|     :|:
Yeast  1373 QS------HKKTKQAVSYDEPDEDEIETMREAEKSSDEEGIDSDKESDSDSEDEDVDMNEQINKS 1431

  Fly  1429 VERLLSNDMVKA-----------------YTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGK 1476
            :.. .:|:|.|.                 |.:|.|:..||:.||.|:...:|..:.:|:.|:..|
Yeast  1432 IVE-ANNNMNKVQRDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEICRK 1495

  Fly  1477 SVVHQVQHIKRAIIYKGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQ 1541
            |::.|:.||.|.:..:..:..::|.|:|:|...|:.....:|::.:.|||:.|:.:|||:|||..
Yeast  1496 SIIRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITSNDVAAVLKTYGVEAARN 1560

  Fly  1542 VIVKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGMEHSSSPLQQMSFESSLQFLKSA 1606
            .||.|::|||..|.|:|..|||.||||.||..||:...:|:|||.|:|...:||:|::.|||..|
Yeast  1561 TIVNEINNVFSRYAISVSFRHLDLIADMMTRQGTYLAFNRQGMETSTSSFMKMSYETTCQFLTKA 1625

  Fly  1607 AGFGRADELSSPSSRLMVGLPVRNGTGAFELLTKI 1641
            ......::|.|||:|::||.....|||:|::|.|:
Yeast  1626 VLDNEREQLDSPSARIVVGKLNNVGTGSFDVLAKV 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpI1	NP_523743.1	RNA_pol_rpoA1	14..1009	CDD:274106	414/1097 (38%)
		RNAP_I_RPA1_N	18..982	CDD:259844	400/1066 (38%)
		RNA_pol_Rpb1_5	936..1593	CDD:282807	247/715 (35%)
		HMG-box	1057..1119	CDD:294061	13/61 (21%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	182/513 (35%)
RPA190	NP_014986.3	RNAP_I_RPA1_N	16..1035	CDD:259844	400/1066 (38%)
RPA190	NP_014986.3	RNA_pol_Rpb1_5	989..1611	CDD:398596	247/714 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345425
Domainoid	1	1.000	360	1.000	Domainoid score	I132
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7033
Inparanoid	1	1.050	991	1.000	Inparanoid score	I28
Isobase	1	0.950	-	0	Normalized mean entropy	S1549
OMA	1	1.010	-	-		QHG54249
OrthoFinder	1	1.000	-	-		FOG0005035
OrthoInspector	1	1.000	-	-		oto100164
orthoMCL	1	0.900	-	-		OOG6_101773
Panther	1	1.100	-	-	LDO	PTHR19376
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1172
SonicParanoid	1	1.000	-	-		X3561
TreeFam	1	0.960	-	-
	16	15.740