Protein Alignment Polr1A and NRPC1

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_001190573.1
• Gene: NRPC1 / 836126
• AraportID: AT5G60040
• Length: 1391
• Species: Arabidopsis thaliana
• Alignment Length: 1706
• Identity: 453/1706 - (26%)
• Similarity: 710/1706 - (41%)
• Gaps: 437/1706 - (25%)

  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTCL-KLQDCPGHM 79
            :.|:|.:|.|:.|.:.|:|.....:|........||.|.|||...: ...|.||. ..|:||||.
plant    26 INFSVLSDLEVMKAAEVQVWNIGLYDHSFKPYENGLLDPRMGPPNK-KSICTTCEGNFQNCPGHY 89

  Fly    80 GHIELGTPVYNPFFIKFVQRLL-CIFCLHCYKLQMKDH---ECEIIMLQLRLIDAGYIIEAQELE 140
            |:::|..||||..:..|:..:| ||    |...::.|:   .|..::|..:|.:
plant    90 GYLKLDLPVYNVGYFNFILDILKCI----CKVTELADYVSLRCSNMLLDEKLYE----------- 139

  Fly   141 LFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITHSALQRL-- 203
                       ::|..::|..|         :.|:|.|  .:.:....||.      .|.||:
plant   140 -----------DHLRKMRNPRM---------EPLKKTE--LAKAVVKKCST------MASQRIIT 176

  Fly   204 GKKCRHCNKSMRFVRYMHRRLVFYVTLADIKERVGTGAETGGQNKVIFADECR---RYLRQIYAN 265
            .|||.:.|..::.:...     |.:.::..:.::     .||:     .|||:   .:.:|..|.
plant   177 CKKCGYLNGMVKKIAAQ-----FGIGISHDRSKI-----HGGE-----IDECKSAISHTKQSTAA 226

  Fly   266 YPELLKLLVP--VLGL------SNTDLTQGDRSPVDLFFMDTLPVTPPRA-RPLNMVGDMLKGNP 321
            ...|..:|.|  ||||      .:.:|......|.:|..  |..:.||.: ||..|:|
plant   227 INPLTYVLDPNLVLGLFKRMSDKDCELLYIAYRPENLII--TCMLVPPLSIRPSVMIG------- 282

  Fly   322 QTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDVLLD 386
                  .|..|.:.|...||.:..|...|       ::.|...|:..|....|..:|:.|...::
plant   283 ------GIQSNENDLTARLKQIILGNASL-------HKILSQPTSSPKNMQVWDTVQIEVARYIN 334

  Fly   387 VNMSREMKSGE-----GLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIFAK 446
            ..:.......|     |:.|.::.|.|..|:::.||||.:..||||:||||:.:.|:|||.:.|:
plant   335 SEVRGCQNQPEEHPLSGILQRLKGKGGRFRANLSGKRVEFTGRTVISPDPNLKITEVGIPILMAQ 399

  Fly   447 KLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAKLLLSNPKDG 511
            .|::|..|:..|:.:||:.|.|||:.:|||..::..:|.:..:..|   .|:.:|..|...
plant   400 ILTFPECVSRHNIEKLRQCVRNGPNKYPGARNVRYPDGSSRTLVGD---YRKRIADELAIG---- 457

  Fly   512 IKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDGDEMNAHYP 576
             .||.||:..|||:|.|||||||:.|||.|:|||:.. :|.|.:.|.|..|||||||||||.|.|
plant   458 -CIVDRHLQEGDVVLFNRQPSLHRMSIMCHRARIMPW-RTLRFNESVCNPYNADFDGDEMNMHVP 520

  Fly   577 QSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQLVFQGLSQL 641
            |:|.||.||..|:.|.:|...||:|..|....||.:.|...::.:..|::|..: .|:...:...
plant   521 QTEEARTEAITLMGVQNNLCTPKNGEILVASTQDFLTSSFLITRKDTFYDRAAF-SLICSYMGDG 584

  Fly   642 KKDIKLLPPTILKPAVLWSGKQILSTII-INIIPEGYERINLDSFAKIAGKNWNVSRPRPPICGT 705
            ...|.|..||||||..||:||||.|.:: .|.....|..:|      :..||:.          .
plant   585 MDSIDLPTPTILKPIELWTGKQIFSVLLRPNASIRVYVTLN------VKEKNFK----------K 633

  Fly   706 NPEGND----LSESQVQIRNGELLVGVLDKQQYGATTY--------GLIHCMYELYGGDVSTLLL 758
            ...|.|    :::..|..||.||:.|.|.|.......:        ||...:...|....:.:.:
plant   634 GEHGFDETMCINDGWVYFRNSELISGQLGKATLALDIFPLGNGNKDGLYSILLRDYNSHAAAVCM 698

  Fly   759 TAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIR----ECR------NVGNSAVAAALE-- 811
            ....|:...::.:.||::|:.|:...:...::|:..|:    :|.      |.||..:.|.|:
plant   699 NRLAKLSARWIGIHGFSIGIDDVQPGEELSKERKDSIQFGYDQCHRKIEEFNRGNLQLKAGLDGA 763

  Fly   812 --LEDEPPHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDI----NSTCLPRGLITKFPSN 870
              ||.|                               :.|..|.|    ...|: .||..:   |
plant   764 KSLEAE-------------------------------ITGILNTIREATGKACM-SGLHWR---N 793

  Fly   871 NLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMT 935
            :..:|...|:|||.:|..|:...:||..:.|.|.|.....:|||.|.....||.:.||:...|.:
plant   794 SPLIMSQCGSKGSPINISQMVACVGQQTVNGHRAPDGFIDRSLPHFPRMSKSPAAKGFVANSFYS 858

  Fly   936 GIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGED 1000
            |:...:||||.|.|||||:||||||:.:||:.|.|:|.||.|.||||.|||::...::||.||:|
plant   859 GLTATEFFFHTMGGREGLVDTAVKTASTGYMSRRLMKALEDLLVHYDNTVRNASGCILQFTYGDD 923

  Fly  1001 GLD--ILKSKFFND----KFCADFLTQNATAILRPAQLQL------MKDEEQLAKVQRHEKHIRS 1053
            |:|  :::.|   |    .|...||...||...|.....|      .|.||:|.   ||:|.
plant   924 GMDPALMEGK---DGAPLNFNRLFLKVQATCPPRSHHTYLSSEELSQKFEEELV---RHDKS--- 979

  Fly  1054 WEKKKPAKLRAAFTHFSEELREEVEV-----KRPNEINSKTGRRRFDEGLLKLWKKADAEDKALY 1113
                     |.....|.:.|||.|.:     ..|.::               |:|.:...||.|
plant   980 ---------RVCTDAFVKSLREFVSLLGVKSASPPQV---------------LYKASGVTDKQL- 1019

  Fly  1114 RKKYARCPDPTVAVYKQDLYYGSVSERTRKLITDYAKRKPALKETIADIMRVKTIKSLAAPGEPV 1178
             :.:.:     :.|::                                 .|.|.|::    |..:
plant  1020 -EVFVK-----ICVFR---------------------------------YREKKIEA----GTAI 1041

  Fly  1179 GLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIK-PGQQHQ 1242
            |.|.|||||||.|||||.||||||...||:|.|:||:.||:. ||.||.||.:...:: |.:...
plant  1042 GTIGAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRINEIIN-ASKNISTPVISAELENPLELTS 1105

  Fly  1243 AEKLRINLNSVTLANLLEYVHVSTGLTLDPERSYEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQ 1307
            |..::..:...||..:.|.:.|....|....|.        .|..::.:|
plant  1106 ARWVKGRIEKTTLGQVAESIEVLMTSTSASVRI--------ILDNKIIEE--------------- 1147

  Fly  1308 TFFKQLIRAILKVSNASRTTKIVVIDDKKDADKEDDND---LDNGDE----VGRSKAKANDDDSS 1365
                    |.|.::..|....|:    |....|.:|||   ||.|.:    |.:|:|..|..:..
plant  1148 --------ACLSITPWSVKNSIL----KTPRIKLNDNDIRVLDTGLDITPVVDKSRAHFNLHNLK 1200

  Fly  1366 DDNDDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVE 1430
            :...:....|:|..:|....:|.                                     ||.:.
plant  1201 NVLPNIIVNGIKTVERVVVAEDM-------------------------------------DKMLA 1228

  Fly  1431 RLLSNDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKRAIIYKGTD 1495
            :|:               :.|.       |:...:|.::
plant  1229 KLI---------------IPCP-------RWACTNLLAV-------------------------- 1245

  Fly  1496 DDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDR 1560
                :.|.||| |.....|.:::           :::|.|||||...|:.|:..|...:|:::|.
plant  1246 ----MGTPGIN-GRTTTSNNVVE-----------VSKTLGIEAARTTIIDEIGTVMGNHGMSIDI 1294

  Fly  1561 RHLSLIADYMTFDGTFQPLSRKGMEH-SSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMV 1624
            ||:.|:||.||:.|....:.|.|::. ..|.|.|.|||.:...|.|||..|:.|.:...:..:::
plant  1295 RHMMLLADVMTYRGEVLGIQRTGIQKMDKSVLMQASFERTGDHLFSAAASGKVDNIEGVTECVIM 1359

  Fly  1625 GLPVRNGTGAFELLTK 1640
            |:|::.|||..::|.:
plant  1360 GIPMKLGTGILKVLQR 1375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	293/1018 (29%)
		HMG-box_SF	1065..1119	CDD:438789	11/58 (19%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	117/480 (24%)
NRPC1	NP_001190573.1	RNAP_III_RPC1_N	31..909	CDD:259847	294/1019 (29%)
		rpoC2	859..>1092	CDD:214368	105/310 (34%)
		RNAP_III_Rpc1_C	1029..1369	CDD:132723	117/513 (23%)