Protein Alignment RpI1 and Polr1a

DIOPT Version :9

• Sequence 1: NP_523743.1
• Gene: RpI1 / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_113960.2
• Gene: Polr1a / 83581
• RGDID: 620824
• Length: 1716
• Species: Rattus norvegicus
• Alignment Length: 1730
• Identity: 749/1730 - (43%)
• Similarity: 1060/1730 - (61%)
• Gaps: 141/1730 - (8%)

  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTCLK-LQDCPGHM 79
            :.|.:::.:|::||||..:......|:||:....||||:.:|. ....:.|.||:: ..:|.||:
  Rat    15 ISFGMYSAEELKKLSVKSITNPRYVDSLGNPSADGLYDLALGP-ADSKEVCSTCVQDFNNCSGHL 78

  Fly    80 GHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAGYIIEAQELELFKS 144
            |||:|...||||.....:..||...||:|:.|........:::.||:::|.|.:....|||...|
  Rat    79 GHIDLPLTVYNPLLFDKLYLLLRGSCLNCHMLTCPRAAIHLLVCQLKVLDVGALQAVYELERILS 143

  Fly   145 EIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNS-TKTSCSLRTAI------THSALQR 202
            ..: :.|.:..|.:..:.:..:.:   |:|:.|...|..: .|..|..|:.:      ||.|
  Rat   144 RFL-EETSDPSAFEIQEELEEYTS---KILQNNLLGSQGAHVKNVCESRSKLVAHFWKTHMA--- 201

  Fly   203 LGKKCRHCNKSMRFVRYMH--RRLVFYVTL---------ADIKERVGTGAETG------GQNKVI 250
             .|:|.||......||..|  :..:.|..:         |::.|  |..|..|      |:...:
  Rat   202 -AKRCPHCKTGRSVVRKEHNSKLTITYPAMVHKKSGQKDAELPE--GAPAAPGIDEAQMGKRGYL 263

  Fly   251 FADECRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVD--LFFMDTLPVTPPRARPLNMV 313
            .....:.:|..|:.|....|..|..  ||.:.    |..|..:  :||:|.:.|.|.|.||:|.:
  Rat   264 TPSSAQEHLFAIWKNEGFFLNYLFS--GLDDI----GPESSFNPSMFFLDFIVVPPSRYRPINRL 322

  Fly   314 GDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEA----------------KAAYQTLK 362
            ||.:..|.|| :.:..:..:.||...|..:...::||..|.                ::....|.
  Rat   323 GDQMFTNGQT-VNLQAVMKDAVLIRKLLAVMAQEQKLPCEMTEITIDKENDSSGAIDRSFLSLLP 386

  Fly   363 GETAHEKLYTAWLALQMSVDVLLDVNMSREM-KSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTV 426
            |::..:|||..|:.||..|:::.|.:|.:.| :...|::||:|||.||.|.|||||||:||||:|
  Rat   387 GQSLTDKLYNIWIRLQSHVNIVFDSDMDKLMLEKYPGIRQILEKKEGLFRKHMMGKRVDYAARSV 451

  Fly   427 ITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPA 491
            |.||..||.:|||||.:||.||:||.|||.|||.|||:.|:|||:|||||:.:.:::|..|.:.|
  Rat   452 ICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINEDGSRTALSA 516

  Fly   492 DNASKRESLAKLLLSN----PK-DGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKT 551
            .:|::||::||.||:.    || .|.|:|.|||.|||:|||||||:||:|||..|:|.||..||.
  Rat   517 VDATQREAVAKQLLTPSTGIPKPQGAKVVCRHVKNGDILLLNRQPTLHRPSIQAHRAHILPEEKV 581

  Fly   552 FRLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGV 616
            .||||:|||||||||||||||||:||||:.|||||.|......|||||||.||.||||||::||.
  Rat   582 LRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQYLVPKDGQPLAGLIQDHMVSGA 646

  Fly   617 KLSIRGRFFNREDYQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERIN 681
            .::|||.||.||.|.:||::||:.....:||.||.||||..||:|||::||::||||||.|..:|
  Rat   647 NMTIRGCFFTREQYMELVYRGLTDKVGRVKLFPPAILKPFPLWTGKQVVSTLLINIIPEDYTPLN 711

  Fly   682 LDSFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMY 746
            |...|||..|.|...:|| |:...:|:  .:.||||.||.||||.|||||..||::.|||:||.|
  Rat   712 LTGKAKIGSKAWVKEKPR-PVPDFDPD--SMCESQVIIREGELLCGVLDKAHYGSSAYGLVHCCY 773

  Fly   747 ELYGGDVSTLLLTAFTKVFTFFLQL-EGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAAL 810
            |:|||:.|..:||...::||.:||| .||||||:||||...||..|::||.|....|..||.|||
  Rat   774 EIYGGETSGRVLTCLARLFTAYLQLYRGFTLGVEDILVKPNADVMRQRIIEESTQCGPRAVRAAL 838

  Fly   811 ELEDEPPHDELVEKMEAAYV-KDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQL 874
            .|.:....||:..|.:.|:: ||.:...::|.|:|..::.|:|:||..|:|.||..:||.||||:
  Rat   839 NLPEAASCDEIQGKWQDAHLGKDQRDFNMIDMKFKEEVNHYSNEINKACMPFGLHRQFPENNLQM 903

  Fly   875 MVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQP 939
            ||.||||||.|||||||||||||||||:|||||.||||||.|..:|.:|::|||:.|||:|||:|
  Rat   904 MVQSGAKGSTVNTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIRP 968

  Fly   940 QDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDI 1004
            .:||||||||||||:|||||||||||||||:|||||||.:.|||||||||.||||||||||||||
  Rat   969 PEFFFHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVIQYDLTVRDSDGSVVQFLYGEDGLDI 1033

  Fly  1005 LKSKFFNDK-FCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPAKL--RAAF 1066
            .|::|...| |  .||..|...|::...|..:.......||.||.:.|:.|..:..:.|  :.||
  Rat  1034 PKTQFLQPKQF--PFLASNYEVIMKSKHLHEVLSRADPQKVLRHFRAIKKWHHRHSSALLRKGAF 1096

  Fly  1067 THFSEELREEVEVKRPN-EINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCPDPTVAVYKQ 1130
            ..||:::  :..||..| |..::.||....:.:|::|.:.|.:.:..|:|:.|.||||:::|::.
  Rat  1097 LSFSQKI--QAAVKALNLEGKTQNGRSPETQQMLQMWHELDEQSRRKYQKRAAPCPDPSLSVWRP 1159

  Fly  1131 DLYYGSVSERTRKLITDYAKRKPALKE-----------TIADIMRVKTIKSLAAPGEPVGLIAAQ 1184
            |:::.||||...|.|.||::...|..|           .:..::::|..:||..|||.|||:|||
  Rat  1160 DIHFASVSETFEKKIDDYSQEWAAQAEKSHNRSELSLDRLRTLLQLKWQRSLCDPGEAVGLLAAQ 1224

  Fly  1185 SIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIKPGQQ--HQAEKLR 1247
            ||||||||||||||||||||||||||||||||||||:||:|||||.|.:|:...::  .:.:.|:
  Rat  1225 SIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVFNTKKALRRVKSLK 1289

  Fly  1248 INLNSVTLANLLEYVHVSTGLTLDPERS--YEYDMRFQFLPREVYKEDYGVRPKHIIKYMHQTFF 1310
            ..|..|.|..:|:.|.:.....:..:::  ..|::||||||...|:::..:||:.|:.:|...||
  Rat  1290 KQLTRVCLGEVLQKVDIQESFCMGEKQNKFRVYELRFQFLPHAYYQQEKCLRPEDILHFMETRFF 1354

  Fly  1311 KQLIRAILKVSNASRTTKIVVIDDKKDADKEDDNDLDNGDEVGRSKAKANDDDSSDDN------- 1368
            |.|:.||.|.:  |:.:....::.::...|    |||:.::.||::.:...|:..:.|
  Rat  1355 KLLMEAIKKKN--SKASAFRSVNTRRATQK----DLDDTEDSGRNRREEERDEEEEGNIVDAEAE 1413

  Fly  1369 -DDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAED----------EDDEEKGQDGNDN 1422
             .|.||:..|.|:::.:|.||:..::.||  :..:|..|.|:          |.|||:|....:.
  Rat  1414 EGDADASDTKRKEKQEEEVDYESEEEGEE--EEEEDVQEEENIKGEGAHQTHEPDEEEGSGLEEE 1476

  Fly  1423 DGDD-----------KAVERLL-----SNDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIR 1471
            ...:           :|:||.:     |:..::.|.||.|..|||||.:.|.:.....|::|::.
  Rat  1477 SSQNPPRRHSRPQGAEAMERRIQAVRESHSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVV 1541

  Fly  1472 ELAGKSVVHQVQHIKRAI----IYKGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIAR 1532
            .||..::|:..:.|.|.:    |....:.:.:|.|:|||:.|:|:::::|||.|||||||||:|.
  Rat  1542 SLAHNAIVYTTKGITRCLLNETINSKNEKEFVLNTEGINLPELFKYSEVLDLRRLYSNDIHAVAN 1606

  Fly  1533 TYGIEAASQVIVKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGMEHSSSPLQQMSFE 1597
            |||||||.:||.||:.:||.||||.||.|||||:||||.|:|.::||:|.|::.||||||||:||
  Rat  1607 TYGIEAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIQSSSSPLQQMTFE 1671

  Fly  1598 SSLQFLKSAAGFGRADELSSPSSRLMVGLPVRNGTGAFEL 1637
            :|.||||.|...|..|||.|||:.|:||..|:.|||.|||
  Rat  1672 TSFQFLKQATMMGSHDELKSPSACLVVGKVVKGGTGLFEL 1711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RpI1	NP_523743.1	RNA_pol_rpoA1	14..1009	CDD:274106	484/1043 (46%)
		RNAP_I_RPA1_N	18..982	CDD:259844	460/1014 (45%)
		RNA_pol_Rpb1_5	936..1593	CDD:282807	298/713 (42%)
		HMG-box	1057..1119	CDD:294061	16/64 (25%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	218/514 (42%)
Polr1a	NP_113960.2	RNAP_I_RPA1_N	16..1011	CDD:259844	460/1015 (45%)
		RNA_pol_Rpb1_5	965..1666	CDD:398596	297/712 (42%)
		Bridging helix. /evidence=ECO:0000250	968..980		9/11 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1368..1493		26/130 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349621
Domainoid	1	1.000	519	1.000	Domainoid score	I298
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7033
Inparanoid	1	1.050	1290	1.000	Inparanoid score	I149
OMA	1	1.010	-	-		QHG54249
OrthoDB	1	1.010	-	-		D57214at33208
OrthoFinder	1	1.000	-	-		FOG0005035
OrthoInspector	1	1.000	-	-		oto98371
orthoMCL	1	0.900	-	-		OOG6_101773
Panther	1	1.100	-	-	LDO	PTHR19376
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3561
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770