Protein Alignment Polr1A and NRPD1B

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_181532.2
• Gene: NRPD1B / 818591
• AraportID: AT2G40030
• Length: 1976
• Species: Arabidopsis thaliana
• Alignment Length: 1649
• Identity: 352/1649 - (21%)
• Similarity: 581/1649 - (35%)
• Gaps: 527/1649 - (31%)

  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMG---SYGRCMDPCGTCLKLQDCPG 77
            :.||:.:..||       .|..|:..|:.|  |..|.:..:|   .:|:| :.|| ..:...|.|
plant    17 ITFALASHHEI-------CIQSISESAINH--PSQLTNAFLGLPLEFGKC-ESCG-ATEPDKCEG 70

  Fly    78 HMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQ--------MKDHECEIIMLQLRLIDAGYII 134
            |.|:|:|..|:|:|..:..::::|.:.||.|.|::        :.|          ||:.
plant    71 HFGYIQLPVPIYHPAHVNELKQMLSLLCLKCLKIKKAKGTSGGLAD----------RLLG----- 120

  Fly   135 EAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITHSA 199
                        ||....:.::||                   ::.|..::.....|      .:
plant   121 ------------VCCEEASQISIK-------------------DRASDGASYLELKL------PS 148

  Fly   200 LQRLGKKCRHCNKSMRFV-RYMHRRLVFYVTLADIKERVGTGAETGGQNKVIFADECRRYLRQIY 263
            ..||...|      ..|: ||.:|                .|::   ..:.:.|.|.:..||:|
plant   149 RSRLQPGC------WNFLERYGYR----------------YGSD---YTRPLLAREVKEILRRI- 187

  Fly   264 ANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLKGNPQTDIYIN 328
               ||          .|...||.....|.:.:.::.||| ||....:....|   |.....:..:
plant   188 ---PE----------ESRKKLTAKGHIPQEGYILEYLPV-PPNCLSVPEASD---GFSTMSVDPS 235

  Fly   329 IIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDVLLDV----NM 389
            .||...||..|:               |...:..|||..|........:...||..|.|    ..
plant   236 RIELKDVLKKVI---------------AIKSSRSGETNFESHKAEASEMFRVVDTYLQVRGTAKA 285

  Fly   390 SREMKSGEGLKQIIEKKSG-----LIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIFAKKLS 449
            :|.:....|:.:|.:..|.     .:|:..:.|...:::|:|||.|...:|:|:|||...|::::
plant   286 ARNIDMRYGVSKISDSSSSKAWTEKMRTLFIRKGSGFSSRSVITGDAYRHVNEVGIPIEIAQRIT 350

  Fly   450 YPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLAKLLLSNPKDGIKI 514
            :...|:..|...|:|:|    |.....:|.|   |.|||...|.:.....|        |.| ::
plant   351 FEERVSVHNRGYLQKLV----DDKLCLSYTQ---GSTTYSLRDGSKGHTEL--------KPG-QV 399

  Fly   515 VHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDGDEMNAHYPQSE 579
            |||.|::|||:.:||.|:.||.|:...:..: |.:.|.:::...|...:||||||.::..||||.
plant   400 VHRRVMDGDVVFINRPPTTHKHSLQALRVYV-HEDNTVKINPLMCSPLSADFDGDCVHLFYPQSL 463

  Fly   580 VARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQLVFQGLSQLKKD 644
            .|:||...|.:|....|....|..:..:..|.::| :::.:...|.::...|||...|      .
plant   464 SAKAEVMELFSVEKQLLSSHTGQLILQMGSDSLLS-LRVMLERVFLDKATAQQLAMYG------S 521

  Fly   645 IKLLPPTILK-----PAVLWSGKQILSTIIINIIPEGYERINL--DSFAKIAGKNWNVSRPRPPI 702
            :.|.||.:.|     ||  |:..|||..    ..|   ||::.  |.|.
plant   522 LSLPPPALRKSSKSGPA--WTVFQILQL----AFP---ERLSCKGDRFL---------------- 561

  Fly   703 CGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTLLLTAFTK-VFT 766
                .:|:||.                 |..:|....|.|  :.|:    |:::.|....| ...
plant   562 ----VDGSDLL-----------------KFDFGVDAMGSI--INEI----VTSIFLEKGPKETLG 599

  Fly   767 FF----------LQLEGFTLGVKDILVTDV-ADRKRRKIIRECRNVGNSAVAAALEL--EDEPPH 818
            ||          |..|||:|.::|:.::.. .|.....||||.     |.:.:.|.|  .||...
plant   600 FFDSLQPLLMESLFAEGFSLSLEDLSMSRADMDVIHNLIIREI-----SPMVSRLRLSYRDELQL 659

  Fly   819 DELVEKMEAA----YVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSG 879
            :..:.|::..    .:|....|.|:|.|..|.:   |..:..|    |.:      .||   ||.
plant   660 ENSIHKVKEVAANFMLKSYSIRNLIDIKSNSAI---TKLVQQT----GFL------GLQ---LSD 708

  Fly   880 AK----GSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSG--GFIDGRFMTGIQ 938
            .|    .::|..|.|.|         ||....||              .||  |.:.|.|..|:.
plant   709 KKKFYTKTLVEDMAIFC---------KRKYGRIS--------------SSGDFGIVKGCFFHGLD 750

  Fly   939 PQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDS-DNSVVQFLYGEDG- 1001
            |.:...|.:|.||.::.::...:..|.|.:.|:..|..:.:..|.|||:: .|||:||.||.|.
plant   751 PYEEMAHSIAAREVIVRSSRGLAEPGTLFKNLMAVLRDIVITNDGTVRNTCSNSVIQFKYGVDSE 815

  Fly  1002 ------------LDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSW 1054
                        :.:|.                |||:..||...::........         ||
plant   816 RGHQGLFEAGEPVGVLA----------------ATAMSNPAYKAVLDSSPNSNS---------SW 855

  Fly  1055 EKKKPAKLRAAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLL-----KLWKKADAEDKAL-- 1112
            |..|...|  ...:|.....:...:...||.:  .|:|...|...     || .|...:|.|:
plant   856 ELMKEVLL--CKVNFQNTTNDRRVILYLNECH--CGKRFCQENAACTVRNKL-NKVSLKDTAVEF 915

  Fly  1113 ---YRKKYARCPDPTVA------------------------VYKQDLY------YGSVSERTRKL 1144
               |||:      ||::                        :..||::      ..|:.::.:|.
plant   916 LVEYRKQ------PTISEIFGIDSCLHGHIHLNKTLLQDWNISMQDIHQKCEDVINSLGQKKKKK 974

  Fly  1145 ITDYAKRKPALKETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHF-AGRGEMNV 1208
            .||..||..         :.|....|...|           .|...:.|...||.: |...::..
plant   975 ATDDFKRTS---------LSVSECCSFRDP-----------CGSKGSDMPCLTFSYNATDPDLER 1019

  Fly  1209 TLGI------PRLREILM-----LASSNIKTPSMDIPIKPGQQHQA-----------EKLRINLN 1251
            ||.:      |.|.||::     :.|:||...|.|:......:|.:           ||..:..:
plant  1020 TLDVLCNTVYPVLLEIVIKGDSRICSANIIWNSSDMTTWIRNRHASRRGEWVLDVTVEKSAVKQS 1084

  Fly  1252 S----VTLANLLEYVHVSTGLTLDPERSYEYDMR---------------FQFLPREVYKEDYGVR 1297
            .    |.:.:.|..:|:     :|.:||..|.::               .|.|...|.....||.
plant  1085 GDAWRVVIDSCLSVLHL-----IDTKRSIPYSVKQVQELLGLSCAFEQAVQRLSASVRMVSKGVL 1144

  Fly  1298 PKHIIKYMHQTF------------FKQLIRAILKVSNASRTTKIVVIDDKKDADKEDDN------ 1344
            .:|||...:...            :|.|.|::   :..:..|:..:|..:|..:|..:.
plant  1145 KEHIILLANNMTCSGTMLGFNSGGYKALTRSL---NIKAPFTEATLIAPRKCFEKAAEKCHTDSL 1206

  Fly  1345 -------------DLDNGDE---VGRSKAKANDDDSSDD------------NDDD-------DAT 1374
                         |:..|.:   :...|....||....|            |.|.       |.|
plant  1207 STVVGSCSWGKRVDVGTGSQFELLWNQKETGLDDKEETDVYSFLQMVISTTNADAFVSSPGFDVT 1271

  Fly  1375 GVKLKQ-RKTDEKD-------YDDPDDVEELHD------ANDDDDEAEDEDDEEKGQDGNDNDGD 1425
            ..::.: .::.|:|       ::|..|.:.|||      ||.:...:.|     .|..|....|.
plant  1272 EEEMAEWAESPERDSALGEPKFEDSADFQNLHDEGKPSGANWEKSSSWD-----NGCSGGSEWGV 1331

  Fly  1426 DKAV--ERLLSNDMVKAYTYDKEN 1447
            .|:.  |....::..|....:||:
plant  1332 SKSTGGEANPESNWEKTTNVEKED 1355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	233/1015 (23%)
		HMG-box_SF	1065..1119	CDD:438789	14/63 (22%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	71/393 (18%)
NRPD1B	NP_181532.2	RNAP_IV_RPD1_N	24..798	CDD:259849	233/1014 (23%)
		RNAP_IV_NRPD1_C	825..1231	CDD:132724	81/469 (17%)
		Ago_hook	<1462..1582	CDD:463088
		DUF3223	1751..1827	CDD:431917