Protein Alignment Polr1A and rpc1

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_595506.1
• Gene: rpc1 / 2541094
• PomBaseID: SPBC651.08C
• Length: 1405
• Species: Schizosaccharomyces pombe
• Alignment Length: 1739
• Identity: 441/1739 - (25%)
• Similarity: 700/1739 - (40%)
• Gaps: 489/1739 - (28%)

  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDALGHAIPG--GLYDIRMGSYGRCMDPCGTC-LKLQDCPG 77
            |:|.:...:|..|...|:|.....:.....: |.  |..|:.||:..:.:: |.|| ..:.||.|
pombe    16 LQFGINGPEEFVKDGTVEVSRRDLYTMTDRS-PAEHGALDLHMGTSNKQIN-CATCGESMADCMG 78

  Fly    78 HMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRL--IDAGYIIEAQELE 140
            |.|:::|..||::..:.|....:|...|..|..:.:.|.|....:..||.  ||          .
pombe    79 HFGYVKLALPVFHIGYFKATLTILQNICKDCSSVLLSDQEKRQFLKDLRRPGID----------N 133

  Fly   141 LFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITHSALQRLGK 205
            |.:|:| |:.            ::.|                      |               |
pombe   134 LRRSQI-CKR------------INDH----------------------C---------------K 148

  Fly   206 KCRHCNKSMRFVRYMHRRLVFYVTLADIKERVGTGAETGGQNKVIFADECRRYLRQ-------IY 263
            |.|.|:|                  .|..:.|   .:..|..|:|  .|..||:|:       ..
pombe   149 KMRRCSK------------------CDAMQGV---VKKAGPLKII--HERFRYVRKSQDDEENFR 190

  Fly   264 ANYPELLKLLVPV---LGLSNTDLTQ-------GDRSPVDLFFMDTLPVTPPRARPLNMVGDMLK 318
            .::.|.||.:..:   |..::.||..       ...:|||   .:.|.:.|...||.|::...:.
pombe   191 HSFDEALKTIPELKMHLSKAHDDLNPLKVLNLFKQITPVD---CELLGMDPEHGRPENLLWRYVP 252

  Fly   319 GNP--------------QTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEK 369
            ..|              :.|:.:.|.|.....:::               :||..  || |....
pombe   253 APPVCIRPSVAQEGATTEDDLTVKITEIIWTSSLI---------------RAALS--KG-TPISN 299

  Fly   370 LYTAWLALQMSVDVLLDVNM------SREMKSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTVIT 428
            |...|..:|:|:.:.::..|      ....|...|..|.::.|.|..|.::.||||:::.||||:
pombe   300 LMEQWEFMQLSIAMYINSEMPGLRPSDMPSKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVIS 364

  Fly   429 PDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDK-NGFTTYIPAD 492
            ||||:.:|::.:|...||.|::|..||..|...|:..:.|||||||||||:.|: :||..::...
pombe   365 PDPNLRIDQVAVPYRIAKILTFPERVTTQNKKHLQDCIRNGPDVHPGANYVIDRESGFKRFLRFG 429

  Fly   493 NASKRESLAKLLLSNPKDGIK---IVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRL 554
            |   |..:|        |.:|   ||.||:.:.||:|.||||||||.|||.|..:: ...:|.|.
pombe   430 N---RNRIA--------DDLKIGDIVERHLHDNDVVLFNRQPSLHKLSIMAHLVKV-RPWRTLRF 482

  Fly   555 HYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLS 619
            :...|..|||||||||||.|.||:|.|:.||..|:.:.:|.:.|::|.|:....||.:.:...||
pombe   483 NECVCGPYNADFDGDEMNLHVPQTEEAKTEALELMGIKNNLVSPRNGEPIIAATQDFITAAYLLS 547

  Fly   620 IRGRFFNREDYQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYER--INL 682
            ::..|.:|:....:... :......|.|.||.|:||..||:|||:. |:::.  |..:.:  :||
pombe   548 LKDTFLDRKSISNICCY-MMDASTHIDLPPPAIIKPRCLWTGKQVF-TVLMK--PNRFSKVLVNL 608

  Fly   683 D----SFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYG-ATTYGLI 742
            |    ||::|..|.       |.:|   |:     :..:.|||.|::.||:||...| .....|.
pombe   609 DAKTRSFSRIKSKT-------PEMC---PK-----DGYLMIRNSEIIAGVVDKSVVGDGKKDSLF 658

  Fly   743 HCMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVA 807
            :.:...||...:...:|..:|:...||...||::|::|:........::..::       |.|.|
pombe   659 YVILRDYGALEAAEAITRLSKMCARFLGNRGFSIGIEDVQPGKSLSSQKEILV-------NKAYA 716

  Fly   808 AALE---------LEDEPPHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPR-G 862
            .:.:         ||.:|..|:     ||.          |:.|..|.|....:|:...|:.. |
pombe   717 TSDDFIMQYAKGILECQPGMDQ-----EAT----------LEAKISSTLSKVRDDVGEICMDELG 766

  Fly   863 LITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGG 927
                 |:|:..:|...|:|||.:|..|:...:||..:.|||.|.....:|||.|......|.:.|
pombe   767 -----PANSPLIMATCGSKGSKINVSQMVACVGQQIISGKRVPDGFQDRSLPHFHKNSKHPLAKG 826

  Fly   928 FIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSV 992
            |:...|.:|:.|.:|.||.::|||||:||||||:.:||:.|.|:|.||.||..||.|||.|::.|
pombe   827 FVSNSFYSGLTPTEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSSAYDGTVRSSNSDV 891

  Fly   993 VQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKK 1057
            |||:||:||||
pombe   892 VQFVYGDDGLD------------------------------------------------------ 902

  Fly  1058 KPAKLRAAFTHFSEELREEVEVKRP--NEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKY-AR 1119
             |.        :.|...:.||.||.  :.:|....|.  |..:|. ::..|..::||...|: ..
pombe   903 -PT--------YMEGDGQAVEFKRTWIHSVNLNYDRH--DSAMLP-YEIIDYVNRALDDPKFLTN 955

  Fly  1120 CPDP------TVAVYKQDLYYGSVSERTRKL-------------------ITDYAKRKPALKETI 1159
            |...      |..:.....|..||.|| |.|                   ....||||     ::
pombe   956 CNRDFIETIRTFVIENIAKYLASVRER-RDLAPMLEEPDMDDLDDMEGDEFAPVAKRK-----SV 1014

  Fly  1160 ADIMRV--------------KTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTL 1210
            .:|:||              |.:::...||..||.|.|||||||.|||||.||||||.. ...||
pombe  1015 ENIIRVTEKQLRSFVDRCWEKYMRAKVEPGTAVGAIGAQSIGEPGTQMTLKTFHFAGVA-AQTTL 1078

  Fly  1211 GIPRLREILMLASSNIKTPSMDIPIKPGQQHQAEKLRINLNSVTLANLLEYVHVSTGLTLDPERS 1275
            |:||::||:. |:..|.||                                  :.||..::
pombe  1079 GVPRIKEIIN-AAKTISTP----------------------------------IITGQLIN---- 1104

  Fly  1276 YEYDMRFQFLPREVYKEDYGVRPKHIIK-YMHQTFFKQLIRAILKVSNASRTTKIVVIDDKKDAD 1339
                             |...|...::| .:.:|:.|.:...|.:|.....|...:.:
pombe  1105 -----------------DRDERSARVVKGRIEKTYLKDVTSYIEEVYGPVTTYLSIQV------- 1145

  Fly  1340 KEDDNDLDNGDEVGRSKAKANDDDSSDDNDDDDATGV----KLK---QRKTDEKDYDDPDDVEEL 1397
                    |.|.:.:.:.        |....|.|..:    |||   |:.|..      :.::::
pombe  1146 --------NFDTISKLQL--------DITLADIAAAIWNTPKLKIPSQQVTVN------NTLQQI 1188

  Fly  1398 HDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVERLLSNDMVKAYTYDKENHLWCQVKLNLSVRYQ 1462
            |.....|.::.:.:...:.|          ..:|:|
pombe  1189 HVHTSSDGKSSETEVYYRLQ----------TYKRVL----------------------------- 1214

  Fly  1463 KPDLTSIIRELAGKSVVHQVQHIKRAIIYKGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDI 1527
             ||:.........:||::| :..|..:..:||....::.|:|| :|.....|.::::     .|:
pombe  1215 -PDVVVAGIPTINRSVINQ-ESGKIELFMEGTGLQAVMNTEGI-VGTKTSTNHVMEM-----KDV 1271

  Fly  1528 HAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGM-EHSSSPL 1591
                  .|||||...|:.|:......:|:|||.||:.|:.|.||..|....::|.|: :...|.|
pombe  1272 ------LGIEAARYSIISEIGYTMAKHGLTVDPRHIMLLGDVMTCKGEVLGITRFGVAKMKDSVL 1330

  Fly  1592 QQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVRNGTGAFELLTK 1640
            ...|||.:...|.:||.....|.:...|..:::|.....||..|:|:.:
pombe  1331 ALASFEKTTDHLFNAAARFAKDSIEGISECIVLGKLAPIGTNVFQLIRR 1379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	285/1026 (28%)
		HMG-box_SF	1065..1119	CDD:438789	13/56 (23%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	108/480 (23%)
rpc1	NP_595506.1	RNAP_III_RPC1_N	22..885	CDD:259847	287/1026 (28%)
		rpoC2	829..>1072	CDD:214368	95/314 (30%)
		RNAP_III_Rpc1_C	1035..1374	CDD:132723	107/477 (22%)