Protein Alignment Polr1A and rpc-1

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_501127.2
• Gene: rpc-1 / 177491
• WormBaseID: WBGene00004411
• Length: 1400
• Species: Caenorhabditis elegans
• Alignment Length: 1701
• Identity: 444/1701 - (26%)
• Similarity: 737/1701 - (43%)
• Gaps: 400/1701 - (23%)

  Fly     5 RAMDVHMFPSDLEFAVFTDQEIRKLSVVKVITGITF-DALGHAIPG--GLYDIRMGSYGRCMDPC 66
            :.:.|...|.|.||       :|:.:.|.:.....: |..|...|.  |..|.:||...: ...|
 Worm    14 KVVGVKFAPGDCEF-------MRQTAHVPIFNNKLYEDVEGKLQPANYGPLDPKMGVSTK-TGTC 70

  Fly    67 GTC-LKLQDCPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDA 130
            .|| |.|.||.||.|:.:|..||::..|.|...:||...|.:|                     :
 Worm    71 STCGLGLTDCVGHFGYFDLDVPVFHIGFFKLTIQLLQCICKNC---------------------S 114

  Fly   131 GYIIEAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAI 195
            ..::..::..:|..:::..|.:.|    :...:|..|.|..|         ..||.:.|.|:...
 Worm   115 SILLTPEQHRVFSRQVMNPNLDYL----HRKALHKRIVAACK---------KGSTCSHCGLKNGT 166

  Fly   196 THSA--------------LQRLGKKCRHCNKSMRFVRYMHRRLVFYVTLADIKERVGTGAETGGQ 246
            ...|              :..|||                     :.|:....:.||
 Worm   167 VKKAVGAVLKIAFASPVSVDELGK---------------------FATMFSSNQEVG-------- 202

  Fly   247 NKVIFADECRR---------YLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPV 302
                  |..|:         :::::::|..|   ..:|||.:.:.:    ::.|.|| .:..:||
 Worm   203 ------DHVRKMKFTLLNPLFVQKLFSNIKE---GDIPVLMVRSGE----EKHPNDL-LLTRMPV 253

  Fly   303 TPPRARPLNMVGDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAH 367
            .|...|| ::|.::..|..:.|:.:.::|.....:|:.|:.:.|....|
 Worm   254 PPVCIRP-SVVSEVKAGTTEDDVTMKLMEIMLTNDVLKKHKRDGAPSKT---------------- 301

  Fly   368 EKLYTAWLALQMSVDVLLDVNMS---------REMKSGEGLKQIIEKKSGLIRSHMMGKRVNYAA 423
              |:..|..||:...:.::..||         |.|::   ..|.::.|.|..|.::.||||:::.
 Worm   302 --LFETWEHLQIQCALYINSEMSGLPPDMQPKRAMRA---FTQRLKGKQGRFRGNLCGKRVDFSG 361

  Fly   424 RTVITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANY-IQDKNGFTT 487
            ||||:||||:.:|::|:|...|..|::|..|...|:.::|::|:||.|||||||| ::.|.|...
 Worm   362 RTVISPDPNLRIDQVGVPIHVAMTLTFPEIVNASNIEKMRQLVINGSDVHPGANYLVEKKTGNKK 426

  Fly   488 YIPADNASKRESLAKLLLSNPKDGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTF 552
            .:   ...||:.|||    |.:.| ..:.||:.:.||:|.||||||||.|||.|:|:::.| :||
 Worm   427 LL---KYGKRDELAK----NLRMG-DTIERHLDDNDVVLFNRQPSLHKISIMSHRAKVMPG-RTF 482

  Fly   553 RLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVK 617
            |.:...|..|||||||||||.|.||:..|:|||..|:||.:|.:.|:.|.||...|||.:..|..
 Worm   483 RFNECACTPYNADFDGDEMNLHLPQTYEAKAEASELMNVKNNLITPRSGEPLVAAIQDFITGGYL 547

  Fly   618 LSIRGRFFNRED---YQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYER 679
            |:.:..|..|.:   :...:....::.:..|::.||.|.:|..||:|||::..|   |.|:....
 Worm   548 LTHKDTFLPRAEVYRFAAALIDASAKKQTKIRIPPPAIRRPVELWTGKQLIELI---IRPDKGSD 609

  Fly   680 INLDSFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATT-YGLIH 743
            ::|:..||......|:.     :|.        .:|.|.|||..||.|.|||...|::: ..:.:
 Worm   610 VSLNLTAKNKSYTGNLE-----LCS--------KDSYVIIRNSVLLAGCLDKSLLGSSSKVNIFY 661

  Fly   744 CMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAA 808
            .:...||.|.:...:....::...||...||::|:.|:       |...:::||...:.::..:.
 Worm   662 MLMRDYGEDAAVDAMWRLARMAPVFLSNRGFSIGIGDV-------RPSEQLLREKGQLVDNGYSK 719

  Fly   809 ALELEDEPPHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQ 873
            ..:...|....:|  |.:....::.....::.|:..::.|    .....||..  ::|:  |...
 Worm   720 CSQYIKELEEGKL--KAQPGCTEEETLESIILRELSTIRD----HAGQVCLRN--LSKY--NAPL 774

  Fly   874 LMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQ 938
            .|.:.|:|||.:|..|:...:||..:.|.|||.....:|||.|...:.:|::.||:...|.:|:.
 Worm   775 TMAVCGSKGSFINISQMIACVGQQAISGHRPPDGFEERSLPHFERKKKTPEAKGFVANSFYSGLT 839

  Fly   939 PQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLD 1003
            |.:||||.|.|||||:||||||:.:||:||.|:|.||.|...||.|||.|...|::|::||||||
 Worm   840 PTEFFFHTMGGREGLVDTAVKTAETGYMQRRLVKCLEDLCASYDGTVRSSVGDVIEFVFGEDGLD 904

  Fly  1004 --ILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPAKLRAAF 1066
              ::::|   |....||     |.:|..|: .:...:||...|.:.::.:::..:|   |.:..:
 Worm   905 PAMMEAK---DGSVVDF-----THVLEHAK-NIQTTKEQPIPVDKLDEVLKAEIQK---KFKGKY 957

  Fly  1067 THFSEELRE---EVEVKRPNEINSKTGRRRFDEGLLKLWKKADA-----EDKALYRKKYAR-CPD 1122
            .||:::|.|   :.|:|:.                 |.|:...|     |...|..|:..: |.:
 Worm   958 VHFADKLSEYITQTEIKKS-----------------KKWQNGKAHCGNHETADLKTKESCKICKN 1005

  Fly  1123 PTVAVYKQDLYYGSVSERTRKLITDYAKRKPALKETIADIMRVKTIKSLAAPGEPVGLIAAQSIG 1187
              :..||..|...|...:|:..             :..::...|..:::..||..||.|||.|||
 Worm  1006 --LEAYKTSLLANSCLTKTQLC-------------SFIELCYYKVARAITEPGTAVGAIAATSIG 1055

  Fly  1188 EPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIP-IKPGQQHQAEKLRINLN 1251
            ||||||||.||||||...||:|.|:||::||:. |...|.||.:... :.|..:..|.:::..:.
 Worm  1056 EPSTQMTLKTFHFAGVASMNITQGVPRIKEIIN-AVKTISTPIITAALLDPYDESLARRVKARIE 1119

  Fly  1252 SVTLANLLEYVHVSTGLTLDPERSYEYDMRFQFLPREVY-KEDY----GVRPKHIIKYMHQTFFK 1311
            ..||..:.:|:                        .||| .:||    .:..|.|.....:...:
 Worm  1120 KTTLGEICDYI------------------------EEVYLPDDYFLLVKLNSKRIRLLQLEVCME 1160

  Fly  1312 QLIRAIL--KVSNASRTTKIVVIDDKKDADKEDDNDLDNGDEVGRSKAKANDDDSSDDNDDDDAT 1374
            .:..||.  ||....|..|||.                    .|::........:|
 Worm  1161 SISYAIATSKVCPQMRGCKIVA--------------------HGKTMMAIRPPSTS--------- 1196

  Fly  1375 GVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVERLLSNDMVK 1439
              ||.:..|.:                                          .::..|:|.:||
 Worm  1197 --KLSKTMTMQ------------------------------------------ILKYSLANVVVK 1217

  Fly  1440 AYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKR----AIIYKGTDDDQLL 1500
            .                         :.|:     .:.|:|..:  |:    :::.:|||...:|
 Worm  1218 G-------------------------IPSV-----NRCVIHADE--KKGDFYSLLVEGTDFRSVL 1250

  Fly  1501 KTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSL 1565
            .:.|:            |..:...|:...:|...|||||...|:.|:......:||.:||||:.|
 Worm  1251 SSVGV------------DPRKTNFNNALVVADVLGIEAARSCIINEIIATMDAHGIGLDRRHVML 1303

  Fly  1566 IADYMTFDGTFQPLSRKGM-EHSSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVR 1629
            :||.||:.|....::|.|: :...|.|...|||.::..|..||.|.:.|.:...|..:::|.|:.
 Worm  1304 LADVMTYRGEVLGITRNGLVKMKDSVLLLASFEKTMDHLFEAAFFSQRDVIHGVSECIIMGTPMT 1368

  Fly  1630 NGTGAFELLTK 1640
            .|||.|:|:.|
 Worm  1369 VGTGTFKLMQK 1379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	278/1004 (28%)
		HMG-box_SF	1065..1119	CDD:438789	12/61 (20%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	116/484 (24%)
rpc-1	NP_501127.2	RNAP_III_RPC1_N	26..887	CDD:259847	282/1009 (28%)
		rpoC2	837..>1080	CDD:214368	99/286 (35%)
		RNAP_III_Rpc1_C	1034..1374	CDD:132723	115/481 (24%)