DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RpI1 and ama-1

DIOPT Version :9

Sequence 1:	NP_523743.1	Gene:	RpI1 / 36617	FlyBaseID:	FBgn0019938	Length:	1642	Species:	Drosophila melanogaster
Sequence 2:	NP_500523.4	Gene:	ama-1 / 177190	WormBaseID:	WBGene00000123	Length:	1856	Species:	Caenorhabditis elegans

Alignment Length:	1774	Identity:	483/1774 - (27%)
Similarity:	741/1774 - (41%)	Gaps:	466/1774 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 SDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMG---SYGRCMDPCGTCL-KLQD 74
            |.::|.:...:||:::||..|.....::. |....|||.|.|.|   ..||||    ||. .|.|
Worm    16 SRVQFGILGPEEIKRMSVAHVEFPEVYEN-GKPKLGGLMDPRQGVIDRRGRCM----TCAGNLTD 75

  Fly    75 CPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAGYIIEAQEL 139
            ||||.||:||..||::..|:....::|...|.:|.:|               |||..   ..:.|
Worm    76 CPGHFGHLELAKPVFHIGFLTKTLKILRCVCFYCGRL---------------LIDKS---APRVL 122

  Fly   140 ELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAITHSALQRLG 204
            |:.|              |.|......:..:|.|               |..::....:|.:..|
Worm   123 EILK--------------KTGTNSKKRLTMIYDL---------------CKAKSVCEGAAEKEEG 158

  Fly   205 -------------KKCRHCNKSMRFVRYM--HRRLVFYVTLADIKERVGTGAETGGQNKVIFADE 254
                         |....|.      ||.  :||:...:. |:.|:.|.   |...:.|::...|
Worm   159 MPDDPDDPMNDGKKVAGGCG------RYQPSYRRVGIDIN-AEWKKNVN---EDTQERKIMLTAE 213

  Fly   255 CRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLKG 319
                  ::...:.::....:.|:|:.    .|..|.  :......|||.|...||..:.....|.
Worm   214 ------RVLEVFQQITDEDILVIGMD----PQFARP--EWMICTVLPVPPLAVRPAVVTFGSAKN 266

  Fly   320 NPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDVL 384
              |.|:       .|.|:.::   |..|:....||       .|..||.......| ||..|..|
Worm   267 --QDDL-------THKLSDII---KTNQQLQRNEA-------NGAAAHVLTDDVRL-LQFHVATL 311

  Fly   385 LD----------VNMSREMKSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIG 439
            :|          ....|.:||   :||.::.|.|.||.::|||||:::||||||.|||:.:|.:|
Worm   312 VDNCIPGLPTATQKGGRPLKS---IKQRLKGKEGRIRGNLMGKRVDFSARTVITADPNLPIDTVG 373

  Fly   440 IPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTT---YIPADNASKRESLA 501
            :|...|:.|::|..||.:||.:|:::|..|...:|||.||..:||...   |.|        ..|
Worm   374 VPRTIAQNLTFPEIVTPFNVDKLQELVNRGDTQYPGAKYIIRENGARVDLRYHP--------RAA 430

  Fly   502 KLLLSNPKDGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADF 566
            .|.|   :.|.: |.||:.:||:::.||||:|||.|:|||:.:||.. .|||::.|....|||||
Worm   431 DLHL---QPGYR-VERHMKDGDIIVFNRQPTLHKMSMMGHRVKILPW-STFRMNLSVTSPYNADF 490

  Fly   567 DGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQ 631
            ||||||.|.|||...|||...:..|....:.|:...|:.|::||.:.:...::.|..|.:.....
Worm   491 DGDEMNLHLPQSLETRAEIEEIAMVPRQLITPQANKPVMGIVQDTLCAVRMMTKRDVFIDWPFMM 555

  Fly   632 QLVFQGLSQLKK-DIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGKNWNV 695
            .|    |..|.. |.|:..|.||||..||:|||:.|.||..                    |.||
Worm   556 DL----LMYLPTWDGKVPQPAILKPKPLWTGKQVFSLIIPG--------------------NVNV 596

  Fly   696 SRPRPPICGTNPEGNDL--------SESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGD 752
            .|..    .|:|:..|.        .:::|.|.:||||.|::..:..|.:...|:|.:....|.:
Worm   597 LRTH----STHPDSEDSGPYKWISPGDTKVIIEHGELLSGIVCSKTVGKSAGNLLHVVTLELGYE 657

  Fly   753 VSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPP 817
            ::....:....|...:|..||.|:|:.|.:.........:..||:.:
Worm   658 IAANFYSHIQTVINAWLIREGHTIGIGDTIADQATYLDIQNTIRKAK------------------ 704

  Fly   818 HDELVEKMEAAYVKD------SKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMV 876
             .::|:.:|.|:..|      :..|...:.|...:|:...:...|:.  :..:::|  ||.:.||
Worm   705 -QDVVDVIEKAHNDDLEPTPGNTLRQTFENKVNQILNDARDRTGSSA--QKSLSEF--NNFKSMV 764

  Fly   877 LSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQD 941
            :||:|||.:|..|:...:||..:||||.|.....::||.|...:..|:|.||::..::.|:.|.:
Worm   765 VSGSKGSKINISQVIACVGQQNVEGKRIPFGFRHRTLPHFIKDDYGPESKGFVENSYLAGLTPSE 829

  Fly   942 FFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLD--- 1003
            ||||.|.||||||||||||:.:||:||.|||.:|.:.|:||.|||:|...:||..|||||||
Worm   830 FFFHAMGGREGLIDTAVKTAETGYIQRRLIKAMESVMVNYDGTVRNSLAQMVQLRYGEDGLDGMW 894

  Fly  1004 -----ILKSKFFNDKFCADF---LTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKPA 1060
                 :...|..|..|..||   ||.|                          |.:|.
Worm   895 VENQNMPTMKPNNAVFERDFRMDLTDN--------------------------KFLRK------- 926

  Fly  1061 KLRAAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLLKL---WKKADAEDKALYRKKYARCPD 1122
                   ::||::..|::              ..::|:..:   |.:.: ||:.|.||.:.|...
Worm   927 -------NYSEDVVREIQ--------------ESEDGISLVESEWSQLE-EDRRLLRKIFPRGDA 969

  Fly  1123 PTV-------------AVYKQDL----------YYGSVSERTRKLI----TDYAKRKPALKET-I 1159
            ..|             .::|.||          ....|.|.::|||    .|...::.....| :
Worm   970 KIVLPCNLQRLIWNAQKIFKVDLRKPVNLSPLHVISGVRELSKKLIIVSGNDEISKQAQYNATLL 1034

  Fly  1160 ADIMRVKTI----------------------------KSLAAPGEPVGLIAAQSIGEPSTQMTLN 1196
            .:|:...|:                            :::|.|||.||.:||||:|||:||||||
Worm  1035 MNILLRSTLCTKNMCTKSKLNSEAFDWLLGEIESRFQQAIAQPGEMVGALAAQSLGEPATQMTLN 1099

  Fly  1197 TFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIKPGQQHQAEKLR---INLNSVTLANL 1258
            |||:||....|||||:|||:||:.: |..:||||:.:.:........||.:   ..|...|
Worm  1100 TFHYAGVSAKNVTLGVPRLKEIINV-SKTLKTPSLTVFLTGAAAKDPEKAKDVLCKLEHTT---- 1159

  Fly  1259 LEYVHVSTGLTLDPERSYEYDMRFQFLPRE-VYKED------YGVRPKHIIKYMHQTFFKQLIRA 1316
            |:.|..:|.:..||:            |:. |..||      :...|.|
Worm  1160 LKKVTCNTAIYYDPD------------PKNTVIAEDEEWVSIFYEMPDH---------------- 1196

  Fly  1317 ILKVSNASRTTKIVV---IDDKKDADKEDDNDLDNGDEVGRSKAKANDDDS--SDDNDDDDATGV 1376
                 :.|||:..::   :|.|:..||:...:: ..|.:  .....||..:  :|||.:
Worm  1197 -----DLSRTSPWLLRIELDRKRMVDKKLTMEM-IADRI--HGGFGNDVHTIYTDDNAE------ 1247

  Fly  1377 KLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKAVERLLSNDMV--- 1438
            ||               |..|..|.:|..||::|.     .|..::|...:.:|..:.:|:.
Worm  1248 KL---------------VFRLRIAGEDKGEAQEEQ-----VDKMEDDVFLRCIEANMLSDLTLQG 1292

  Fly  1439 -----KAY-----TYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKRAIIYKG 1493
                 |.|     |.||:..:                   |..|...|||.
Worm  1293 IPAISKVYMNQPNTDDKKRII-------------------ITPEGGFKSVA-------------- 1324

  Fly  1494 TDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITV 1558
               |.:|:|||..:..:....:| |..|..||||..|....||||..:.|.:|:.||....|..|
Worm  1325 ---DWILETDGTALLRVLSERQI-DPVRTTSNDICEIFEVLGIEAVRKAIEREMDNVISFDGSYV 1385

  Fly  1559 DRRHLSLIADYMTFDGTFQPLSRKGMEHSS-SPLQQMSFESSLQFLKSAAGFGRADELSSPSSRL 1622
            :.|||:|:.|.||..|....::|.|:.... ..|.:.|||.::..|..||.....|.:...|..:
Worm  1386 NYRHLALLCDVMTAKGHLMAITRHGINRQEVGALMRCSFEETVDILMEAAVHAEEDPVKGVSENI 1450

  Fly  1623 MVGLPVRNGTGAFELLTKI 1641
            |:|...|.|||.|:|:..:
Worm  1451 MLGQLARCGTGCFDLVLDV 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpI1	NP_523743.1	RNA_pol_rpoA1	14..1009	CDD:274106	309/1049 (29%)
		RNAP_I_RPA1_N	18..982	CDD:259844	293/1010 (29%)
		RNA_pol_Rpb1_5	936..1593	CDD:282807	201/755 (27%)
		HMG-box	1057..1119	CDD:294061	10/64 (16%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	140/528 (27%)
ama-1	NP_500523.4	PRK08566	7..893	CDD:236292	309/1037 (30%)
		RNAP_II_RPB1_N	17..870	CDD:259848	293/1013 (29%)
		RNA_pol_Rpb1_5	824..1420	CDD:282807	200/754 (27%)
		RNA_pol_Rpb1_6	890..1073	CDD:282801	36/237 (15%)
		RNAP_II_Rpb1_C	1053..1468	CDD:132720	140/518 (27%)
		CTD	1493..1584	CDD:215026
		CytochromB561_N	<1735..>1828	CDD:286826
		DUF3432	1746..1837	CDD:288743
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0086
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D591636at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820