Protein Alignment Polr1A and rpoa-1

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_001022450.1
• Gene: rpoa-1 / 175015
• WormBaseID: WBGene00012999
• Length: 1737
• Species: Caenorhabditis elegans
• Alignment Length: 1768
• Identity: 698/1768 - (39%)
• Similarity: 986/1768 - (55%)
• Gaps: 207/1768 - (11%)

  Fly    14 SDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMGSYGRCMDPCGTCLKLQ-DCPG 77
            |:.:...:...||.||||:|:....|||.:||.|.|||||..:|. ....|.|.||.:.: .|||
 Worm    16 SNFKLRSYFPHEIDKLSVLKITQTKTFDEVGHPIAGGLYDPILGP-DNTFDMCMTCNQYERHCPG 79

  Fly    78 HMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDH--ECEIIMLQLRLIDAGYIIEAQELE 140
            |||||:|..||:||...:|...||...|:||::|..|..  ...:::.|||..:.|....|.:||
 Worm    80 HMGHIQLAVPVFNPLLFQFTYNLLKGSCVHCHRLTCKGDGVNARMLLAQLRCFELGVEHVAFDLE 144

  Fly   141 LFKSEIVCQNTENLVAIKNGDM-----------VHPHIAAM-YKLLEKNEKNSSNSTKTSCSLR- 192
            ....:          .|.|.|:           |...||.: .|.|.:.....|..||.|..|:
 Worm   145 SILRD----------KIANADLFGDDDSKTFNDVDACIAQLANKPLSELTAFKSMPTKNSVQLKK 199

  Fly   193 ---TAITHSALQRLGKKCRHCNKSMRFVRYMHRR--LVFYVTLA--------------------- 231
               |....|.|.:..:||..|......:|....|  |:.:.:.|
 Worm   200 DIITEFLRSHLFKRLQKCPLCKNRNGVLRNDGARSILIDFTSGARGGGKSKKAIIIIGDNGYNEE 264

  Fly   232 -----DIKERVGTGAETGG------------QNKVIFADEC----------RRYLRQIYANYPEL 269
                 |.:::.|.|||..|            |.|.:...||          |.:.|.::.|..:|
 Worm   265 SSTDEDEEKKGGGGAEVTGDVVDLDEGSLEMQMKNVRTGECDKLAWRGAEVREHFRMLFKNDGKL 329

  Fly   270 LKLLVPVL--GLSNTDLTQGDRSPVDLFFMDTLPVTPPRARPLNMVGDMLKGNPQTDIYINIIEN 332
            |..|.|:|  .|:..|:.    .|:|..|::.:.|.|.:.||:.|.......:|||.....::|.
 Worm   330 LLKLFPMLVDELNGEDMI----CPLDGLFLERILVPPKKFRPIRMFKGAQYEDPQTLNLRKVLEA 390

  Fly   333 NHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEKLYTAWLALQMSVDVLLDVNMSR-EMKSG 396
            ...::.:...|||......:|..|  ..::|:|.:.:::.|:|.||:..:.:.|.:::: :..|.
 Worm   391 TETISAISLIMKGDTSAQLKELIA--NRVRGKTINAQMHDAYLQLQLRANAIFDQDLNKGDRDSI 453

  Fly   397 EGLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTE 461
            .|:|||:|||.||.|.||||||||:|.|:||||||.:::|||||||||||||::..||..:||.|
 Worm   454 AGIKQILEKKQGLFRMHMMGKRVNFACRSVITPDPYLDIDEIGIPDIFAKKLTFTEPVNAFNVNE 518

  Fly   462 LRKMVMNGPDVHPGANYIQDKNGFTTYI--PADNASKRESLAKLLLSNPKDGIK---IVHRHVLN 521
            ::.::..||..|||||:..:.:|..|.:  ..:...:|..:||.|.:...:.::   .|.||:.|
 Worm   519 MKGLLRQGPHQHPGANFFVEPSGKKTMLGDKPEEKKRRMQMAKTLNAATTENLRQTPKVLRHMKN 583

  Fly   522 GDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAY 586
            ||::::|||||||||||:||:||:|.|::..|::|:.||||||||||||||.|..||.:|:.|..
 Worm   584 GDMIMMNRQPSLHKPSILGHRARVLTGQRALRMNYAPCKAYNADFDGDEMNGHLVQSHIAQTEVR 648

  Fly   587 NLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFNREDYQQLVFQGLSQLKKDIKLLPPT 651
            .:.||.||:|||||.|||.|||||||:|||.||:|.||.|:||:..||....:|..|.|::.|||
 Worm   649 EIANVGSNFLVPKDATPLLGLIQDHVVSGVLLSVRDRFLNKEDFMHLVLASFAQYSKRIEIPPPT 713

  Fly   652 ILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGKNWNVSRPRPPICGTNPEGNDLSESQ 716
            ||.|..||:|||:::||:.|.||:|...||||..||.....|.|.       |.:....|:|||.
 Worm   714 ILYPKRLWTGKQVITTIVKNCIPDGKPLINLDGKAKTPLSCWIVP-------GFDAPQFDMSESH 771

  Fly   717 VQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDI 781
            |..|.||||||||||..:|||.:||.||.:||||......||:.|:::||.:||..||||||.||
 Worm   772 VVFRQGELLVGVLDKAHFGATQFGLAHCAFELYGHRCGVQLLSCFSRLFTTYLQFHGFTLGVADI 836

  Fly   782 LVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPPHDELVEKMEAAYVK------DSKFRVLLD 840
            ||...||.||::.:.|.|.:||..|..|..|.|.....|:...:.|.|..      |.|   :||
 Worm   837 LVVKDADGKRKEAVMESRTIGNQVVKTAFGLPDTATPAEIKRTLAATYCNPRGQGTDVK---MLD 898

  Fly   841 RKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPP 905
            ...|..:..|.:.|..:|:|.||:..||.|.||||:.||||||.||.:|||..||||||||||..
 Worm   899 FGMKQGIAKYNDAITKSCVPTGLLRLFPQNALQLMIQSGAKGSAVNAIQISGCLGQIELEGKRMA 963

  Fly   906 LMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCL 970
            :.|:|::||||..|:.||::||:||.||:||:.||:.|||.|||||||||||||||||||||||:
 Worm   964 VTIAGRTLPSFRCFDPSPRAGGYIDQRFLTGMNPQELFFHTMAGREGLIDTAVKTSRSGYLQRCI 1028

  Fly   971 IKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLM 1035
            ||||||:.||||.||||.|.||:||.|||||:|..|:.|.|.| ...||..|..|:...::.:.:
 Worm  1029 IKHLEGIRVHYDSTVRDHDGSVIQFRYGEDGMDTTKATFLNKK-TMPFLEDNLEAVTLASKPEGV 1092

  Fly  1036 KDEE-QLAKVQRHEKHIRSWEKK--KPAK------LRAAFTHFSEELREEVEVKRPNEINSKTGR 1091
            .|.: .:.:.::..|.|..|:||  |..|      ..:|||:||.| ...:|.||
 Worm  1093 TDADFGIKETEKRYKKIVKWKKKAEKSGKSGTKKSYFSAFTNFSAE-HIGMEKKR---------- 1146

  Fly  1092 RRFDEGLLKLWKKADAEDKALYRKKYAR-----CPDPTVAVYKQDLYYGSVSER---------TR 1142
                  :|.:|.:...|:    |::|||     ||:.....:......|::.|:         ||
 Worm  1147 ------ILAMWFELSLEE----REQYARGIPKKCPEAVDERFNPTCKLGALPEKMLDEIEGFCTR 1201

  Fly  1143 --KLITDYAKRKPALKETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGE 1205
              |.:.|....|..||.|    :..|.::|||.|||.|||:||||||||||||||||||||||||
 Worm  1202 RVKKVDDEEPPKEVLKRT----LYWKGMRSLADPGENVGLLAAQSIGEPSTQMTLNTFHFAGRGE 1262

  Fly  1206 MNVTLGIPRLREILMLASSNIKTPSMDIPIKPG-QQHQAEKLRINLNSVTLANLLEYVHVSTGLT 1269
            |||||||||||||||.||.:|.|||..|.:..| .:.:.:.::..|:.|.|..||:...:...:|
 Worm  1263 MNVTLGIPRLREILMTASKSIATPSASIAVIAGTSRDRIDSIKRELDRVYLKQLLKNFSLEEKIT 1327

  Fly  1270 LDPERS-YEYDMRFQFLPREVYKEDYGVR---PKHIIKYMHQTFFKQLIRAILKVSNASRTTKIV 1330
            |...:| ..|.:|...|..|  |.:.|.|   ...|::.:.:.|..::.:||.|        |..
 Worm  1328 LTQNQSCRRYHLRIDILAAE--KRELGARHLKRSQIMEEIEKRFILRVAQAIKK--------KYH 1382

  Fly  1331 VIDDKKDADKED--DNDLDNGDEVGRSKAKA----NDDDSSDDNDDD----DATGVKLKQRKTDE 1385
            .|.|.:......  ..::..|.|.|.:|.:.    ::.||||:..|.    ||...:|.:|..||
 Worm  1383 EITDYQQMSHRTMRQGNMAAGIETGGTKNRGLQGPDNGDSSDEEADGGREADAAEARLHRRHRDE 1447

  Fly  1386 -KDYDDPDDVEELHDANDDDD--EAEDEDDEEKGQDGND--------NDGDDKAVERLLSNDMVK 1439
             .||:..|  ||..:..::::  :::.||.:::|.||.|        |....::|:||..|  :.
 Worm  1448 GADYEGED--EERVEVREEEEPMDSDSEDVKKEGLDGEDQTTEPLLVNSSRIQSVQRLSEN--IS 1508

  Fly  1440 AYTYDKENHLWCQVKLNLSVRYQ-KPDLTSIIRELAGKSVVHQVQHIKRAI---IYKGTDDDQLL 1500
            :||||.:::.||:|...|.:|.: |.|::||:.:.....:|||...|:|.:   ..|...:..:|
 Worm  1509 SYTYDVKSNKWCEVVFELPLRNKTKMDVSSIVEKEVELFIVHQTPGIERCVETTEQKNGKEMTIL 1573

  Fly  1501 KTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVYGITVDRRHLSL 1565
            :|.|:|:...|:|..:||:|.:||||::.|...||:||.|:.|..|::|||.||||.|.:|||||
 Worm  1574 QTQGVNLAAFFKHADVLDVNSVYSNDLNLILENYGVEACSKAITTEMNNVFAVYGIEVSKRHLSL 1638

  Fly  1566 IADYMTFDGTFQPLSRKGMEHSSSPLQQMSFESSLQFLKSAAGFGRADELSSPSSRLMVGLPVRN 1630
            .||||||.|..||.:|..|..||||||:|:||:::.||:.|...|..|.::|||:||::|...|.
 Worm  1639 TADYMTFTGQIQPFNRGAMSSSSSPLQKMTFETTMAFLREALLHGEEDNVNSPSARLVMGALPRG 1703

  Fly  1631 GTGAFELL--TKI 1641
            |||:|:||  ||:
 Worm  1704 GTGSFDLLLDTKM 1716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	432/1046 (41%)
		HMG-box_SF	1065..1119	CDD:438789	14/53 (26%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	200/501 (40%)
rpoa-1	NP_001022450.1	PRK14977	10..1713	CDD:184940	696/1763 (39%)
		RNAP_I_RPA1_N	23..1040	CDD:259844	432/1043 (41%)