Protein Alignment Polr1A and POLR3A

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_008986.2
• Gene: POLR3A / 11128
• HGNCID: 30074
• Length: 1390
• Species: Homo sapiens
• Alignment Length: 1718
• Identity: 466/1718 - (27%)
• Similarity: 733/1718 - (42%)
• Gaps: 441/1718 - (25%)

  Fly     5 RAMDVHMFPSDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIP--GGLYDIRMGSYGRCMDPCG 67
            |..||....|.:.|.:.:.:|:|:.:.::|::...:.......|  .|:.|.|||:..:.. ||.
Human     7 RETDVAKKISHICFGMKSPEEMRQQAHIQVVSKNLYSQDNQHAPLLYGVLDHRMGTSEKDR-PCE 70

  Fly    68 TCLK-LQDCPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAG 131
            ||.| |.||.||.|:|:|..|.::..:.:.|..:|.:.|..|         |.|::.|..
Human    71 TCGKNLADCLGHYGYIDLELPCFHVGYFRAVIGILQMICKTC---------CHIMLSQEE----- 121

  Fly   132 YIIEAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAIT 196
               :.|.|:..|                                                |..:|
Human   122 ---KKQFLDYLK------------------------------------------------RPGLT 135

  Fly   197 HSALQRLGKK------------CRHCN------KSMRFVRYMHRRLVFYVTLADIKERVGTGAET 243
            :  ||:.|.|            |.||.      |....::.:|.:   |.|...:.:.:.:....
Human   136 Y--LQKRGLKKKISDKCRKKNICHHCGAFNGTVKKCGLLKIIHEK---YKTNKKVVDPIVSNFLQ 195

  Fly   244 GGQNKVIFADECRRYLRQIYANYPELLKLL---------VPVLGLSNTDLTQGDRSPVDLFFMDT 299
            ..:..:....|....|.:...|...|:.|.         ||:| |.|.:..:    |.|| .:..
Human   196 SFETAIEHNKEVEPLLGRAQENLNPLVVLNLFKRIPAEDVPLL-LMNPEAGK----PSDL-ILTR 254

  Fly   300 LPVTPPRARPLNMVGDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGE 364
            |.|.|...|| ::|.|:..|..:.|:.:.:.|...:.:|:.|:...|       ||.
Human   255 LLVPPLCIRP-SVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRISG-------AKT-------- 303

  Fly   365 TAHEKLYTAWLALQMSVDVLLD-------VNMSREMKSGEGLKQIIEKKSGLIRSHMMGKRVNYA 422
               :.:...|..||:...:.::       :||:.: |...|..|.::.|.|..|.::.||||:::
Human   304 ---QMIMEDWDFLQLQCALYINSELSGIPLNMAPK-KWTRGFVQRLKGKQGRFRGNLSGKRVDFS 364

  Fly   423 ARTVITPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKN---- 483
            .||||:||||:.:||:.:|...||.|::|..|.:.|:..|||:|.|||:||||||:||.::
Human   365 GRTVISPDPNLRIDEVAVPVHVAKILTFPEKVNKANINFLRKLVQNGPEVHPGANFIQQRHTQMK 429

  Fly   484 GFTTYIPADNASKRESLAKLLLSNPKDGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHG 548
            .|..|      ..||.:|:.|    |.| .||.||:::|||:|.||||||||.|||.|.||: ..
Human   430 RFLKY------GNREKMAQEL----KYG-DIVERHLIDGDVVLFNRQPSLHKLSIMAHLARV-KP 482

  Fly   549 EKTFRLHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVI 613
            .:|||.:...|..|||||||||||.|.||:|.|:|||..|:...:|.:.|::|.||...|||.:.
Human   483 HRTFRFNECVCTPYNADFDGDEMNLHLPQTEEAKAEALVLMGTKANLVTPRNGEPLIAAIQDFLT 547

  Fly   614 SGVKLSIRGRFFNREDYQQLVFQGLSQLKKD----IKLLPPTILKPAVLWSGKQILSTIIINIIP 674
            ....|:::..||:|....|::...|  :.||    ::|.|||||||..||:||||.| :|:....
Human   548 GAYLLTLKDTFFDRAKACQIIASIL--VGKDEKIKVRLPPPTILKPVTLWTGKQIFS-VILRPSD 609

  Fly   675 EGYERINLDSFAKIAGKNWNVSRPRPPICGTNPEGNDL--SESQVQIRNGELLVGVLDKQQYGA- 736
            :...|.||    :..||.:         ||   :|.||  ::|.|.|:|.||:.|.:||...|:
Human   610 DNPVRANL----RTKGKQY---------CG---KGEDLCANDSYVTIQNSELMSGSMDKGTLGSG 658

  Fly   737 TTYGLIHCMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIR----- 796
            :...:.:.:...:|.:.:...::...::...:|...||::|:.|:.......:.:.:::.
Human   659 SKNNIFYILLRDWGQNEAADAMSRLARLAPVYLSNRGFSIGIGDVTPGQGLLKAKYELLNAGYKK 723

  Fly   797 -----ECRNVGNSAVAAALELEDEPPHDELVEKMEAAYVKDSKFRVLLDRKYKSLLDGYTNDINS 856
                 |..|.|        :|:.: |.....|.:||..:|:  ..|:.|.            ..|
Human   724 CDEYIEALNTG--------KLQQQ-PGCTAEETLEALILKE--LSVIRDH------------AGS 765

  Fly   857 TCLPRGLITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFET 921
            .||..  :.|  ||:...|.|.|:|||.:|..|:...:||..:.|.|.|.....:|||.|.....
Human   766 ACLRE--LDK--SNSPLTMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSK 826

  Fly   922 SPKSGGFIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVR 986
            .|.:.||:...|.:|:.|.:||||.|||||||:||||||:.:||:||.|:|.||.|...||||||
Human   827 LPAAKGFVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVR 891

  Fly   987 DSDNSVVQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHI 1051
            .|...::||:||.||||                         ||.:: .|||
Human   892 SSTGDIIQFIYGGDGLD-------------------------PAAME-GKDE------------- 917

  Fly  1052 RSWEKKKPA-KLRAAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRK 1115
             ..|.|:.. .::|.|...||....:      ||:...|      |.::|             :.
Human   918 -PLEFKRVLDNIKAVFPCPSEPALSK------NELILTT------ESIMK-------------KS 956

  Fly  1116 KYARCPDPTVAVYKQDLYYGSVSERTRKLITDYA----------------KRKPALKETIADIMR 1164
            ::..|.|..:...|:  :...|||:.:|....|.                :..|...|...:..|
Human   957 EFLCCQDSFLQEIKK--FIKGVSEKIKKTRDKYGINDNGTTEPRVLYQLDRITPTQVEKFLETCR 1019

  Fly  1165 VKTIKSLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTP 1229
            .|.:::...||..||.:.|||||||.|||||.||||||...||:|||:||::||:. ||..|.||
Human  1020 DKYMRAQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIIN-ASKAISTP 1083

  Fly  1230 SMDIPI-KPGQQHQAEKLRINLNSVTLANLLEYVHVSTGLTLDPERSYEYDMRFQFLPREVYKED 1293
            .:...: |......|..::..:....|..:.||:..                  .|||.:.:
Human  1084 IITAQLDKDDDADYARLVKGRIEKTLLGEISEYIEE------------------VFLPDDCF--- 1127

  Fly  1294 YGVRPKHIIKYMHQTFFKQLIRAILKVS-NASRTTKIVVIDDKKDADKEDDNDLDNGDEVGRSKA 1357
                                  .::|:| ...|..::.|                |.:.|..|..
Human  1128 ----------------------ILVKLSLERIRLLRLEV----------------NAETVRYSIC 1154

  Fly  1358 KANDDDSSDDNDDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDN 1422
            .:                 ||:.:         |.|| .:|
Human  1155 TS-----------------KLRVK---------PGDV-AVH------------------------ 1168

  Fly  1423 DGDDKAVERLLSNDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKR 1487
               .:||..:...:..|:..|             ..:::.|.||.        |.||..:..:.|
Human  1169 ---GEAVVCVTPRENSKSSMY-------------YVLQFLKEDLP--------KVVVQGIPEVSR 1209

  Fly  1488 AIIY----KGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVS 1548
            |:|:    .|.:..:|| .:|.|:..:...:.:.. .|..||:.:.:.:|.|||||...|:.|:.
Human  1210 AVIHIDEQSGKEKYKLL-VEGDNLRAVMATHGVKG-TRTTSNNTYEVEKTLGIEAARTTIINEIQ 1272

  Fly  1549 NVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGM-EHSSSPLQQMSFESSLQFLKSAAGFGRA 1612
            .....:|:::||||:.|::|.||:.|....::|.|: :...|.|...|||.:...|..||.||:.
Human  1273 YTMVNHGMSIDRRHVMLLSDLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQK 1337

  Fly  1613 DELSSPSSRLMVGLPVRNGTGAFELLTK 1640
            |.:...|..:::|:|:..|||.|:||.|
Human  1338 DSVCGVSECIIMGIPMNIGTGLFKLLHK 1365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	300/1021 (29%)
		HMG-box_SF	1065..1119	CDD:438789	8/53 (15%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	117/478 (24%)
POLR3A	NP_008986.2	RNAP_III_RPC1_N	24..891	CDD:259847	303/1021 (30%)
		rpoC2	841..>1058	CDD:214368	92/283 (33%)
		Bridging helix. /evidence=ECO:0000250|UniProtKB:G3MZY8	843..884		27/40 (68%)
		RNAP_III_Rpc1_C	1021..1360	CDD:132723	116/475 (24%)
		Trigger loop. /evidence=ECO:0000250|UniProtKB:G3MZY8	1029..1070		28/40 (70%)