DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpI1 and polr1a

DIOPT Version :9

Sequence 1:NP_523743.1 Gene:RpI1 / 36617 FlyBaseID:FBgn0019938 Length:1642 Species:Drosophila melanogaster
Sequence 2:XP_031751156.1 Gene:polr1a / 100158635 XenbaseID:XB-GENE-1005160 Length:1784 Species:Xenopus tropicalis


Alignment Length:1719 Identity:736/1719 - (42%)
Similarity:1049/1719 - (61%) Gaps:119/1719 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LEFAVFTDQEIRKLSVVKVITGITFDALGHAIPGGLYDIRMG-SYGRCMDPCGTCLK-LQDCPGH 78
            :.|..::.:|||||||..:......|.||:.:..||||:.:| :.|:  :.|.||.: ..:||||
 Frog    83 VSFGCYSAEEIRKLSVKALTNPHYMDNLGNPMMNGLYDLALGPADGK--EVCSTCAQDFNNCPGH 145

  Fly    79 MGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAGYIIEAQELELFK 143
            :|||||...||||.|...:..|:...|.||:.|........:::.||:::|.|.:.|..|||...
 Frog   146 LGHIELPLTVYNPLFFDKLYLLVRGSCFHCHLLTCHRSVIHLLLNQLKVLDRGAVHEVHELENVL 210

  Fly   144 SEIVCQN---TENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSN-STKTSCSLRTAITHS--ALQR 202
            ..::..|   |.|.:..:.||...       |:|:|.:|.... |.|.:|..|..:..:  ..|.
 Frog   211 HRLLEANAAATGNEIREELGDHTR-------KVLKKYKKQPGGISVKNTCVTRNQLIGNFWKTQM 268

  Fly   203 LGKKCRHCNKSMRFVRYMHR-RLVFYVTLADIKERVGTGAETGGQNKVIFADEC--RRYLRQIYA 264
            :..||.:|......||..|. :|...::........|......|..:|..:.:.  |.||..  .
 Frog   269 VSAKCPNCKAPRSVVRKEHNSKLTIIMSSKSSASSKGGNKPAEGDTEVADSSQLAKRGYLTP--N 331

  Fly   265 NYPELLKLLVPVLGLSNTDLTQG------DRSPVDLFFMDTLPVTPPRARPLNMVGDMLKGNPQT 323
            :..||:|.|....|.....|..|      .....|.||:|.:.|.|.|.||:|.:||.:..|..|
 Frog   332 STKELIKALWENEGFFLQHLFSGITGNGESAFTPDTFFLDIIVVPPSRYRPVNRLGDQVFTNGHT 396

  Fly   324 DIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQ----------------TLKGETAHEKLYT 372
            .....::::..::..:|..|...||::.|..::...                ||.|::..:|||.
 Frog   397 VNLQAVLKDVSMIQKLLAVMAQDQEQMPEVTESGMSLKEGEVTENIDRSFLATLMGQSLTDKLYN 461

  Fly   373 AWLALQMSVDVLLDVNMSREM-KSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTVITPDPNINVD 436
            :|:.||..|:::.|.:|.:.| :...|::|::|||.||.|.|||||||:||||:||.||..||.:
 Frog   462 SWVRLQSHVNIVFDSDMDKLMTEKYPGIRQVLEKKEGLFRKHMMGKRVDYAARSVICPDMYINTN 526

  Fly   437 EIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKNGFTTYIPADNASKRESLA 501
            |||||.:||.||:||.|||.|||.|||:.|||||:|||||:.:..::|..|.:.:.|.|:||::|
 Frog   527 EIGIPMVFATKLTYPQPVTPWNVQELRQAVMNGPNVHPGASMVISEDGSRTILNSSNVSQREAVA 591

  Fly   502 KLLLSNPKDG-----IKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFRLHYSNCKA 561
            |.||: |..|     .|||.|||.|||||||||||:||:|||..||||||.|||..||||:||||
 Frog   592 KQLLT-PSTGAQTLAAKIVCRHVKNGDVLLLNRQPTLHRPSIQAHKARILPGEKVLRLHYANCKA 655

  Fly   562 YNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKLSIRGRFFN 626
            |||||||||||||:||||:.|||||:|......||||||||||.||||||::||..::|||.||.
 Frog   656 YNADFDGDEMNAHFPQSELGRAEAYSLACTDEQYLVPKDGTPLAGLIQDHMVSGANMTIRGCFFT 720

  Fly   627 REDYQQLVFQGLSQLKKDIKLLPPTILKPAVLWSGKQILSTIIINIIPEGYERINLDSFAKIAGK 691
            ||.|.:||:|||:..:..:|:|||.||||..||:|||::||::||:|||....:||...|||:||
 Frog   721 REQYMELVYQGLTDKRGRVKVLPPAILKPYPLWTGKQVVSTLLINVIPENLIPLNLTGKAKISGK 785

  Fly   692 NWNVSRPRPPICGTNPEGNDLSESQVQIRNGELLVGVLDKQQYGATTYGLIHCMYELYGGDVSTL 756
            .|...:|| ||.|.:|:  .:.||||.||:||||.|||||..||::::||:||.||||||:.|..
 Frog   786 AWVKEQPR-PIPGFSPD--SMCESQVIIRDGELLCGVLDKAHYGSSSFGLVHCCYELYGGETSGK 847

  Fly   757 LLTAFTKVFTFFLQL-EGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAVAAALELEDEPPHDE 820
            |||...::||.:||| .||||||:||||...||.:|..|:::..:.|..|:.||..|.:....:|
 Frog   848 LLTCLARLFTAYLQLYRGFTLGVEDILVLPYADAQRLNIVQQSLHCGGKAIRAAFNLSEAASDEE 912

  Fly   821 LVEKMEAAYV-KDSKFRVLLDRKYKSLLDGYTNDINSTCLPRGLITKFPSNNLQLMVLSGAKGSM 884
            ...|.:.|:: ||.:...::|.|:|..::.:.|:||..|:|.||...||.|||||||.||||||.
 Frog   913 AHGKWQDAHLSKDQRDFNMVDLKFKEEVNQFNNEINKVCMPFGLHRPFPENNLQLMVQSGAKGST 977

  Fly   885 VNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGGFIDGRFMTGIQPQDFFFHCMAG 949
            |||||||||||||||||:|||||.||:|||.|..::.||:||||:.|||:|||:|.:||||||||
 Frog   978 VNTMQISCLLGQIELEGRRPPLMPSGRSLPCFQPYDFSPRSGGFVTGRFLTGIKPPEFFFHCMAG 1042

  Fly   950 REGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSVVQFLYGEDGLDILKSKFFNDK- 1013
            ||||:|||||||||||||||:|||||||.|.|||||||||.||:||||||||||:.|::|...| 
 Frog  1043 REGLVDTAVKTSRSGYLQRCIIKHLEGLVVQYDLTVRDSDGSVIQFLYGEDGLDVPKTQFLQPKQ 1107

  Fly  1014 FCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKKKP--AKLRAAFTHFSEELREE 1076
            |  .|:.:|...|.:...|..:.......:.::|...|..|:.:.|  ::..:.|..:|::....
 Frog  1108 F--PFIAENYEVIKQSKHLDEVLSRVNTEQAEQHNHAIYRWKARHPNLSQRISPFLLYSQKQMAA 1170

  Fly  1077 VEVKRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCPDPTVAVYKQDLYYGSVSERT 1141
            .:...|||:: :.||......:|:.|..|:.:.::.|.::.:..|||.:||::.|||.|||||..
 Frog  1171 AKASCPNELD-ENGRDLASRKVLESWYAANEKTRSKYVRRSSTLPDPCLAVWRPDLYLGSVSENF 1234

  Fly  1142 RKLITDYA----KRKPALK-------ETIADIMRVKTIKSLAAPGEPVGLIAAQSIGEPSTQMTL 1195
            :..:..|.    :::.:.:       :::..::.:|..::|..||:.|||:||||||||||||||
 Frog  1235 QSKMAQYGCLWEEQRDSSQGMSSLTFDSLKTLLHLKWQRALCDPGDAVGLLAAQSIGEPSTQMTL 1299

  Fly  1196 NTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIPIKPGQQ--HQAEKLRINLNSVTLANL 1258
            |||||||||||||||||||||||||:||:|||||.|.:|:...::  .:.::|:..|..|.||.:
 Frog  1300 NTFHFAGRGEMNVTLGIPRLREILMVASANIKTPMMSVPVLNTKKAVKKVKQLKKKLTRVCLAEV 1364

  Fly  1259 LEYVHVSTGLTLDPERSYEYD---MRFQFLPREVYKEDYGVRPKHIIKYMHQTFFKQLIRAILKV 1320
            :..:.|.....:: |:|.:|.   :||.|||.|.|:::..:||:.::::|...|||.:..||.:.
 Frog  1365 IHKLDVEETFRIE-EKSQKYQVYKIRFHFLPHEYYRQEKLLRPEGVLRFMETRFFKIMFDAIKRK 1428

  Fly  1321 SNASRTTKIVVIDDKKDADKEDDNDLDNGDE----VGRSKAKANDDDSSDDNDDDDATGVKLKQR 1381
            |  |:......:..::...|:..:..|.|::    |...:.:.|.||..||.::.||.....|:|
 Frog  1429 S--SKLASFREVGTRRATQKDHGDGEDQGNQESQPVENEEEQVNADDDDDDAEEGDADATDKKRR 1491

  Fly  1382 KTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGD--------------------- 1425
            |..|::.|...:.||..:.| :::....|..||...|..:|.||                     
 Frog  1492 KKQEEEVDYESEEEEAEEDN-EEEVGSPEAGEETSADVKENTGDIVDEIEENSHSPVPARRPQSG 1555

  Fly  1426 -------DKAVERLLS-NDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQV 1482
                   :..:..:|| |..::.|.||.||.|||::.:.|.:.....|:.|::..||..::||:.
 Frog  1556 LAKEVVAENRINDVLSLNSAIEDYCYDTENSLWCEITIKLQLMKIHFDICSLVSSLAHSAIVHET 1620

  Fly  1483 QHIKRAII----YKGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVI 1543
            ..|.|.::    .|..|.:.:|.|:|||:.|:|:::.||:|.||||||||.:|:|:|||||.:|:
 Frog  1621 SGITRCLLNDTANKQGDKELILNTEGINLYELFKYSNILELRRLYSNDIHTMAKTFGIEAALRVV 1685

  Fly  1544 VKEVSNVFKVYGITVDRRHLSLIADYMTFDGTFQPLSRKGMEHSSSPLQQMSFESSLQFLKSAAG 1608
            .:|:.:||.||||.||.|||||:||||.|:||::||:|.||:.||||.|||:||:|.:|||.|..
 Frog  1686 EREIKDVFAVYGIEVDPRHLSLVADYMCFEGTYKPLNRIGMQSSSSPFQQMTFETSYKFLKDATM 1750

  Fly  1609 FGRADELSSPSSRLMVGLPVRNGTGAFEL 1637
            .|..|:|.|||:.|:||..|:.|||.|:|
 Frog  1751 NGARDDLQSPSACLVVGKVVKGGTGLFDL 1779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpI1NP_523743.1 RNA_pol_rpoA1 14..1009 CDD:274106 490/1033 (47%)
RNAP_I_RPA1_N 18..982 CDD:259844 468/1004 (47%)
RNA_pol_Rpb1_5 936..1593 CDD:282807 281/712 (39%)
HMG-box 1057..1119 CDD:294061 12/63 (19%)
RNAP_I_Rpa1_C 1166..1638 CDD:132722 210/514 (41%)
polr1aXP_031751156.1 RNAP_I_RPA1_N 84..1075 CDD:259844 468/1005 (47%)
rpoC2_cyan 961..>1306 CDD:274104 174/347 (50%)
RNAP_I_Rpa1_C 1270..1780 CDD:132722 210/514 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 497 1.000 Domainoid score I361
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H7033
Inparanoid 1 1.050 1284 1.000 Inparanoid score I166
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D57214at33208
OrthoFinder 1 1.000 - - FOG0005035
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR19376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3561
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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