Protein Alignment Polr1A and polr3a

DIOPT Version :10

• Sequence 1: NP_523743.1
• Gene: Polr1A / 36617
• FlyBaseID: FBgn0019938
• Length: 1642
• Species: Drosophila melanogaster
• Sequence 2: NP_001096178.1
• Gene: polr3a / 100124725
• XenbaseID: XB-GENE-1012749
• Length: 1390
• Species: Xenopus tropicalis
• Alignment Length: 1712
• Identity: 457/1712 - (26%)
• Similarity: 726/1712 - (42%)
• Gaps: 429/1712 - (25%)

  Fly     5 RAMDVHMFPSDLEFAVFTDQEIRKLSVVKVITGITFDALGHAIP--GGLYDIRMGSYGRCMDPCG 67
            |..||....|.:.|.|.:.:::|:.:.:::::...:....:..|  .|:.|.|||:..:... |.
 Frog     6 RETDVAKKISHICFGVKSAEQMRQQAHIQIVSKSLYSQDNNHTPLAFGVLDHRMGTSEKDRH-CQ 69

  Fly    68 TCLK-LQDCPGHMGHIELGTPVYNPFFIKFVQRLLCIFCLHCYKLQMKDHECEIIMLQLRLIDAG 131
            ||.| |.:|.||.|:::|..|.::..:.|.|..:|.:.|..|.::.:...|
 Frog    70 TCGKNLAECLGHYGYLDLELPCFHVGYFKAVIGILQMICKTCSRILLNAEE-------------- 120

  Fly   132 YIIEAQELELFKSEIVCQNTENLVAIKNGDMVHPHIAAMYKLLEKNEKNSSNSTKTSCSLRTAIT 196
               ..|.|:..|                    .|.:..:.|...|.:.:.....||.|....|..
 Frog   121 ---RKQFLDFLK--------------------RPGLTYLQKRGLKKKISDKCRKKTVCLYCGAYN 162

  Fly   197 HSALQRLGKKCRHCNKSMRFVRYMHRRLVFYVTL----------------------ADIKERVGT 239
            .|.     |||       ..::.:|.:   |.|.                      .:::..:|.
 Frog   163 GSV-----KKC-------GLLKIIHEK---YKTTKKVVDPMVSHFLQSFDTAIEHNKEVESLLGR 212

  Fly   240 GAETGGQNKVIFADECRRYLRQIYANYPELLKLLVPVLGLSNTDLTQGDRSPVDLFFMDTLPVTP 304
            ..|  ..|.:|..:    .||||.|....|| |:.|..|           .|.|| .:..|.|.|
 Frog   213 AQE--NLNPLIVLN----LLRQIPAEDIPLL-LMNPEAG-----------KPSDL-ILTRLLVPP 258

  Fly   305 PRARPLNMVGDMLKGNPQTDIYINIIENNHVLNVVLKYMKGGQEKLTEEAKAAYQTLKGETAHEK 369
            ...|| ::|.|:..|..:.|:.:.:.|...:.:|:.|:...|       ||.           :.
 Frog   259 LCIRP-SVVSDLKSGTNEDDLTMKLTEIIFLNDVIKKHRITG-------AKT-----------QM 304

  Fly   370 LYTAWLALQMSVDVLLD-------VNMSREMKSGEGLKQIIEKKSGLIRSHMMGKRVNYAARTVI 427
            :...|..||:...:.::       :||:.: |...|..|.::.|.|..|.::.||||:::.||||
 Frog   305 IMEDWDFLQLQCALYINSELSGIPMNMAPK-KWTRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVI 368

  Fly   428 TPDPNINVDEIGIPDIFAKKLSYPVPVTEWNVTELRKMVMNGPDVHPGANYIQDKN----GFTTY 488
            :||||:.:||:.:|...||.|::|..|.:.|:..:||:|.||||||||||:||.::    .|..|
 Frog   369 SPDPNLRIDEVAVPVHVAKILTFPEKVNQANMQLMRKLVQNGPDVHPGANFIQQRHTQMKRFLKY 433

  Fly   489 IPADNASKRESLAKLLLSNPKDGIKIVHRHVLNGDVLLLNRQPSLHKPSIMGHKARILHGEKTFR 553
                  ..||.:|:.|...     .||.||:::||::|.||||||||.|||.|.||: ...:|||
 Frog   434 ------GNREKIAQELRFG-----DIVERHLIDGDIVLFNRQPSLHKLSIMAHIARV-KPHRTFR 486

  Fly   554 LHYSNCKAYNADFDGDEMNAHYPQSEVARAEAYNLVNVASNYLVPKDGTPLGGLIQDHVISGVKL 618
            .:...|..|||||||||||.|.||:|.|:||||.|:...:|.:.|::|.||...|||.:.:...|
 Frog   487 FNECVCTPYNADFDGDEMNLHLPQTEEAKAEAYVLMGTKANLVTPRNGEPLIAAIQDFLTAAYLL 551

  Fly   619 SIRGRFFNREDYQQLVFQGLSQLKKD----IKLLPPTILKPAVLWSGKQILSTIIINIIPEGYER 679
            :::..||:|....|::...|  :.||    ::|.||.||||..||:|||:.| :|:....:...|
 Frog   552 TLKDTFFDRAKACQIIASIL--VGKDEKIKVRLPPPAILKPVTLWTGKQVFS-LILQPSHDNPVR 613

  Fly   680 INLDSFAKIAGKNWNVSRPRPPICGTNPEGNDL--SESQVQIRNGELLVGVLDKQQYGA-TTYGL 741
            .||    :..||.:         ||   :|.||  ::|.|.|:|.||:.|.|||...|: :...:
 Frog   614 ANL----RTKGKQY---------CG---KGEDLCHNDSYVTIQNSELMCGSLDKGTLGSGSKNNI 662

  Fly   742 IHCMYELYGGDVSTLLLTAFTKVFTFFLQLEGFTLGVKDILVTDVADRKRRKIIRECRNVGNSAV 806
            .:.:...:|...:...::...::...||...||::|:.|:                  ..|...:
 Frog   663 FYILLRDWGQVEAADAMSRLARLAPVFLSNRGFSIGIGDV------------------TPGQGLL 709

  Fly   807 AAALELEDE--PPHDELVEKMEAAYVK-------DSKFRVLLDRKYKSLLDGYTNDINSTCLPRG 862
            .|..:|.|.  ...||.:|.:....::       :.....|:.|:...:.|    ...|.||..
 Frog   710 KAKQDLLDAGYKKCDEYIEALNTGKLQPQPGCSAEETLEALILRELSVIRD----HAGSACLRE- 769

  Fly   863 LITKFPSNNLQLMVLSGAKGSMVNTMQISCLLGQIELEGKRPPLMISGKSLPSFTSFETSPKSGG 927
             :.|  ||:..:|.|.|:|||.:|..|:...:||..:.|.|.|.....:|||.|......|.:.|
 Frog   770 -LDK--SNSPLIMALCGSKGSFINISQMIACVGQQAISGSRVPDGFENRSLPHFEKHSKLPAAKG 831

  Fly   928 FIDGRFMTGIQPQDFFFHCMAGREGLIDTAVKTSRSGYLQRCLIKHLEGLSVHYDLTVRDSDNSV 992
            |:...|.:|:.|.:||||.|||||||:||||||:.:||:||.|:|.||.|...||||||.|...:
 Frog   832 FVANSFYSGLTPTEFFFHTMAGREGLVDTAVKTAETGYMQRRLVKSLEDLCSQYDLTVRSSTGDI 896

  Fly   993 VQFLYGEDGLDILKSKFFNDKFCADFLTQNATAILRPAQLQLMKDEEQLAKVQRHEKHIRSWEKK 1057
            :||:||.||||                         ||.::...:..:..:|..:.|.:... .:
 Frog   897 IQFIYGGDGLD-------------------------PAAMEGKDEPLEFKRVLENVKAVYPC-SE 935

  Fly  1058 KPAKLRAAFTHFSEELREEVEVKRPNEINSKTGRRRFDEGLLKLWKKADAEDKALYRKKYARCPD 1122
            :||..:......||.:.::.|                                      :..|.|
 Frog   936 EPALSKNELILTSESIMKKTE--------------------------------------FLCCQD 962

  Fly  1123 PTVAVYKQDL--YYGSVSERTRKLITDYA----------------KRKPALKETIADIMRVKTIK 1169
            .    |.|::  :...||||.:|....|.                :..|...|...:..|.|.::
 Frog   963 S----YLQEIKKFVTGVSERIKKTRDKYGINDNGTTEPRVLYQLDRITPTQLEKFLETCRDKYMR 1023

  Fly  1170 SLAAPGEPVGLIAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMLASSNIKTPSMDIP 1234
            :...||..||.:.|||||||.|||||.||||||...||:|||:||::||:. ||.||.||.
 Frog  1024 AQMEPGSAVGALCAQSIGEPGTQMTLKTFHFAGVASMNITLGVPRIKEIIN-ASKNISTPI---- 1083

  Fly  1235 IKPGQQHQAEKLRINLNSVTLANLLEYVHVSTGLTLDPERSYEYDMRFQFLPREVYKEDYGVRPK 1299
                                         ::..|.:|.:..:.     :.:...:.|...|
 Frog  1084 -----------------------------ITAHLDIDDDADFA-----RLVKGRIEKTLLG---- 1110

  Fly  1300 HIIKYMHQTFFKQLIRAILKVS-NASRTTKIVVIDDKKDADKEDDNDLDNGDEVGRSKAKANDDD 1363
            .|.:|:.:.|.......::|:| ...|..::.|                |.:.|..|...:
 Frog  1111 EISEYIEEVFLPDDCFLLVKLSLERIRLLRLEV----------------NAETVRYSICMS---- 1155

  Fly  1364 SSDDNDDDDATGVKLKQRKTDEKDYDDPDDVEELHDANDDDDEAEDEDDEEKGQDGNDNDGDDKA 1428
                         ||:.:         |.|:
 Frog  1156 -------------KLRVK---------PGDI---------------------------------- 1164

  Fly  1429 VERLLSNDMVKAYTYDKENHLWCQVKLNLSVRYQKPDLTSIIRELAGKSVVHQVQHIKRAIIY-- 1491
               .:..:.|...| .:||.       ..|:.|    :...::|...|.||..:..:.||:|:
 Frog  1165 ---AVHGEAVLCVT-PRENS-------KSSMYY----VLQSLKEDLPKVVVQGIPEVARAVIHID 1214

  Fly  1492 --KGTDDDQLLKTDGINIGEMFQHNKILDLNRLYSNDIHAIARTYGIEAASQVIVKEVSNVFKVY 1554
              .|.:..:|| .:|.|:..:...:.:.. :|..||:.:.:.:|.|||||...|:.|:......:
 Frog  1215 EQSGKEKYKLL-VEGDNLRSVMATHGVKG-SRTTSNNTYEVEKTLGIEAARSTIINEIQYTMVNH 1277

  Fly  1555 GITVDRRHLSLIADYMTFDGTFQPLSRKGM-EHSSSPLQQMSFESSLQFLKSAAGFGRADELSSP 1618
            |:::||||:.|:||.||:.|....::|.|: :...|.|...|||.:...|..||.||:.|.:...
 Frog  1278 GMSIDRRHVMLLADLMTYKGEVLGITRFGLAKMKESVLMLASFEKTADHLFDAAYFGQKDSVCGV 1342

  Fly  1619 SSRLMVGLPVRNGTGAFELLTK 1640
            |..:::|:|:..|||.|:||.|
 Frog  1343 SECIIMGIPMNIGTGLFKLLHK 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Polr1A	NP_523743.1	RNAP_I_RPA1_N	18..982	CDD:259844	297/1015 (29%)
		HMG-box_SF	1065..1119	CDD:438789	3/53 (6%)
		RNAP_I_Rpa1_C	1166..1638	CDD:132722	116/477 (24%)
polr3a	NP_001096178.1	RNAP_III_RPC1_N	23..890	CDD:259847	299/1015 (29%)
		RNAP_III_Rpc1_C	1020..1359	CDD:132723	115/474 (24%)