DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	546	Identity:	149/546 - (27%)
Similarity:	251/546 - (45%)	Gaps:	107/546 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLPILIHL----SPYIS-AQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAP 72
            ||.:|||:    ||..| .:.|||...:|.|..:|    .|:..|:.|||||:|:.|:..|||||
  Rat    17 LLLLLIHVQGQHSPESSPIRNTHIGQVRGKLDHVK----DTKAGVHTFLGIPFAKPPVGPLRFAP 77

  Fly    73 AKPSSSFNRTLQATTMQPLCPQLANTIYDESSDG------SMPRSVSTDEDCLYLNIWTPESGMR 131
            .:....::.....|:...:|.|..:.|   :::|      .:| .||..||||||||:.|.....
  Rat    78 PEAPEPWSGVRDGTSQPAMCLQNLDVI---NAEGLKEMKLKLP-PVSMSEDCLYLNIYAPAHAHE 138

  Fly   132 YGKLPIVV------IVTGEEFAYDWPRNRINGLDLAGEGIVVVSVQYRNNIYGWLSLGEQHRNVP 190
            ...||::|      ::||....||.....:|      |.:|||::|||..:.|:.|.|::|..
  Rat   139 GSNLPVMVWIHGGGLMTGMASMYDGSLLTVN------EDLVVVTIQYRLGVLGFFSTGDEHAR-- 195

  Fly   191 GNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPG--- 252
            ||:|..|...||||:::|...||||||.:|:.|..:||..::.......|..:....:|..|
  Rat   196 GNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVAL 260

  Fly   253 -PIMRALGQNHQKWIVETGQV---LVQKL-GCQFEEAQRRQLMGCLRRKSREDLLRAYESVYNHG 312
             |.:          |.:|.::   :|.|: ||:..:::  .|:.|||.||..::|...:.|
  Rat   261 LPYL----------IADTSEMFSTMVAKVSGCEAMDSE--ALVHCLRAKSEAEILAINKVV---- 309

  Fly   313 NGSSQL--GVILPEGLPL--EQRLRNKTLPPV--LLGITSNEGAFLQDYWL------------DV 359
                |:  .|:..|.||.  ::.|.::...||  ::|:.::|..     |.            ::
  Rat   310 ----QMVPAVVDGEFLPRHPKELLASEDFRPVPSIIGVNNDEYG-----WTIPLVMGTTQMIKEL 365

  Fly   360 AREG-QVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWRYFNGKGEGVSHLLAGMQRLLSES 423
            :||. |..|.|.....:||  :...:.:.||            :.|..|....|.|....|:.:.
  Rat   366 SRENLQAILKKTTAQLMLP--LECSDLLMEE------------YMGDIEDPKTLQAQFTELMEDF 416

  Fly   424 LYELPYSRILELLNGTTSYA--YVFDHSHSMD-MRGRRNLFGGASHSSDLPLLLGPSLFQQIARR 485
            ::.:|   .|::.:...|:|  |.::..|.:. ::..|.....|.|..::|.:.|  .|....:.
  Rat   417 MFVIP---ALQVAHFQCSHAPVYFYEFQHQITFLKDIRPPHVKADHGDEIPFVFG--YFFWDMKT 476

  Fly   486 RFSGEEEQLCRKIRGAFANFIKNGNP 511
            .|:.||:.|.|::...:|||.::|||
  Rat   477 DFTEEEKLLSRRMMKYWANFARHGNP 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	141/527 (27%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	142/532 (27%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	38/110 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920