Protein Alignment CG12869 and NLGN2

DIOPT Version :10

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 133/548 - (24%)
• Similarity: 225/548 - (41%)
• Gaps: 95/548 - (17%)

  Fly    50 GAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSDGSMPRSV-- 112
            |.|..|||:|||..|:...||.|.:..:|:.....|||:.|.|||        :..|::|..:
Human    64 GPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQ--------NLHGALPAIMLP 120

  Fly   113 ---------------STDEDCLYLNIWTP-ESG------------------MRYGKLPIVVIVTG 143
                           :..|||||||::.| |.|                  ...||.|:::.:.|
Human   121 VWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHG 185

  Fly   144 EEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRR 207
            ..: .:...|..:|..||..| ::|.::.||..:.|:||.|:|  ...|||||.|...||||:..
Human   186 GSY-MEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQ--AAKGNYGLLDQIQALRWLSE 247

  Fly   208 NADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQV 272
            |...|||:|:.||:.|.|:|.:.:.|:.....|..:.|..:...|..:.:...|:|.  ::..::
Human   248 NIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQP--LKYTRL 310

  Fly   273 LVQKLGCQFEEAQRRQLMGCLRRKSREDLL--RAYESVYNHGNGSSQLGVILPEGLPLEQRLRNK 335
            |..|:||..|::  .:.:.|||||...:|:  ....:.|:...|....|.::|:...:..:....
Human   311 LAAKVGCDREDS--AEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEF 373

  Fly   336 TLPPVLLGITSNEG-AFLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRW 399
            ....:|:|:...|| .|::|     :.|.:..:........:.|.:..|....|........|::
Human   374 LNYDMLIGVNQGEGLKFVED-----SAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKF 433

  Fly   400 RYFN----GKGEGVSHLLAGMQR-----LLSESLYELPYSRILELLNGTTSYAYVFDHSHSMDMR 455
            .|.:    ..||        |:|     |.::..:..|.....:|.....|..|.:...|.....
Human   434 MYTDWADRDNGE--------MRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAE 490

  Fly   456 GRRNLFGGASHSSDLPLLLGPSLF--QQIARRRFSGEEEQLCRKIRGAFANFIKNGNPT------ 512
            ||.. :..|:|..:||.:.|..:.  ..:....||..:..|...:...:.||.|.|:|.
Human   491 GRPE-WADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQD 554

  Fly   513 -------PGRIYD-GWLPYN-KENPFVY 531
                   |.|..: .|..:| ||..:::
Human   555 TKFIHTKPNRFEEVVWSKFNSKEKQYLH 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	133/548 (24%)
NLGN2	NP_065846.1	COesterase	42..601	CDD:395084	133/548 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835