Protein Alignment CG12869 and NLGN4X

DIOPT Version :9

• Sequence 1: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 145/575 - (25%)
• Similarity: 241/575 - (41%)
• Gaps: 90/575 - (15%)

  Fly    26 AQQTHIKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQ 89
            ||...:....|.:.||:. .|:...|.|..:||:|||..|..|.||.|.:|.||:......|...
Human    43 AQYPVVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFA 107

  Fly    90 PLCPQLANTIYDESS--------------DGSMPRSVSTDEDCLYLNIWTP-ESGM--------- 130
            .:|||    ..||.|              |..|......:||||||||:.| |.|.
Human   108 AVCPQ----HLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDI 168

  Fly   131 -------------RYGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG-IVVVSVQYRNNIYGWLS 181
                         :..|.|::|.:.|..: .:...|.|:|..||..| ::|:::.||..|.|:||
Human   169 TSNDRGEDEDIHDQNSKKPVMVYIHGGSY-MEGTGNMIDGSILASYGNVIVITINYRLGILGFLS 232

  Fly   182 LGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQL 246
            .|:|  ...|||||.|...|||||..|..||||:|..:|:.|.|:|.:.::|:.....|..:.|.
Human   233 TGDQ--AAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQK 295

  Fly   247 VLMSPGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCLRRKSREDLLR--AYESVY 309
            .::..|..:.:...|:|.  .:..::|..|:||...:.  ..::.|||.|:.::|::  ...:.|
Human   296 AIIQSGTALSSWAVNYQP--AKYTRILADKVGCNMLDT--TDMVECLRNKNYKELIQQTITPATY 356

  Fly   310 NHGNGSSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQDYWLDVAREGQVALHKYI 371
            :...|....|.::|:.  :.:|| ...|.   .::||:...||....|..:|  .|..|..:.:
Human   357 HIAFGPVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGLKFVDGIVD--NEDGVTPNDF- 415

  Fly   372 NHTLLPNVMRALESVGEESSTQLAAIRWRYFN-GKGEGVSHLLAGMQRLLSESLYELPYSRILEL 435
             ...:.|.:..|....|...|....|::.|.: ...|........:..|.::..:..|.....:|
Human   416 -DFSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADL 479

  Fly   436 --LNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL-----LLGPSLFQQIARRRFSGEEEQ 493
              ..|:.:|.|.|.|....:|:..   :..::|..::|.     ::||:   ::....||..:..
Human   480 HAQYGSPTYFYAFYHHCQSEMKPS---WADSAHGDEVPYVFGIPMIGPT---ELFSCNFSKNDVM 538

  Fly   494 LCRKIRGAFANFIKNGNPT-------------PGRIYD-GWLPYNKENPFVYSLG 534
            |...:...:.||.|.|:|.             |.|..: .|..||.::.....:|
Human   539 LSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWSKYNPKDQLYLHIG 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	144/574 (25%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	145/575 (25%)
		Aes	<179..>286	CDD:223730	41/109 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810