DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and ces2b

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	553	Identity:	140/553 - (25%)
Similarity:	248/553 - (44%)	Gaps:	69/553 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQL 95
            :..:.|.|.|..:...|....:.::..||:|::|:..||..|.:|:.::.....||...|:|.|.
Zfish   557 VNTKLGSLRGSYMMAKGKDSVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVRDATKQPPMCLQP 621

  Fly    96 ANTIYDESSDGSMPRSV---STDEDCLYLNIWTPESGMRYGKLPIVVIVTGEEFAYDWPRNRING 157
            ...:.|..:  :||...   ...||||||||:||.......|||::|.:.|...|:. ..:..:.
Zfish   622 KEVMVDLLA--TMPLKTEFPEVSEDCLYLNIYTPSKPGDNKKLPVMVWIHGGGLAFG-SASIFDA 683

  Fly   158 LDLAG-EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITL 221
            ..||. :.||||.||||..:.|:.|.|::|  .||||||.|...||:|::.|..:|||:|..:|:
Zfish   684 HALAAYQDIVVVMVQYRLGLLGFFSTGDEH--APGNYGLLDQVAALQWVQENIHSFGGDPGSVTV 746

  Fly   222 LGHGSGGAPLALVA-----------TLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQ 275
            .|..:||...:|:.           .:.:|.......:|||.|:             .|.:.|..
Zfish   747 FGESAGGVSASLLVLSPLSANLFHRAIAESGTAAMNAIMSPDPL-------------STARSLGN 798

  Fly   276 KLGCQFEEAQRRQLMGCLRRKSREDLLR-AYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLP- 338
            ..||..  :..::::.|:.:.:.||:|: |.|.|... .|.:..|..||:.  :::.|:::...
Zfish   799 VSGCDI--SSTKKIVDCVMQMTEEDILKIAREQVLLR-FGVTVDGQFLPKS--VDELLQSQEFSK 858

  Fly   339 -PVLLGITSNEGAF-LQDY-----WLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAA 396
             |::.|:|.::|.| |.::     |.|...:.|:.       ..||.....|:..|      ||.
Zfish   859 VPLMTGVTDDDGGFTLPEFIAPPGWRDGMTKDQIM-------PFLPTYNYDLQDPG------LAE 910

  Fly   397 IRWRYFNGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTSYAYVFDHSH-SMDMRGRRNL 460
            |..:.:.|.......:..|.:.::.:..:.||..::......|.:..|:::..| :...:.:|..
Zfish   911 IVLKEYLGATTDKIKIRDGFREIVGDFFFNLPARKLANYHRDTGAPVYMYEFQHPAYIFQNKRPS 975

  Fly   461 FGGASHSSDLPLLLGPSLFQQIAR--RRFSGEEEQLCRKIRGAFANFIKNGNPT-PGRIYDGWLP 522
            |.|..|..:|..:.|........:  ...|.||::||:.....:.||.:.|||. ||.:  .|..
Zfish   976 FVGCDHGDELLFVFGYCFGNGHIKVEGELSKEEQELCKTTMAYWGNFARTGNPNGPGLV--EWPK 1038

  Fly   523 YNKENPFVYSLGEQAKTPQT--GSVDEAEVDKL 553
            |..|..:: .:|.:.|:.:.  |:.....::||
Zfish  1039 YGAEAEYL-GIGLEQKSSKNFKGNHFHFMIEKL 1070

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	137/537 (26%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613
		COesterase	553..1065	CDD:306613	138/546 (25%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000