DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	598	Identity:	153/598 - (25%)
Similarity:	258/598 - (43%)	Gaps:	104/598 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRLLPILIHLSPYIS---AQQTH--IKLEQGDLIGLKV-FPDGTRGAVYAFLGIPYAQAPINELR 69
            |||...::..:.:::   ||| |  :....|.|.|||. .|:...|.|..:||||||..|..|.|
Zfish    21 LRLFTWIVLAAAWLAITWAQQ-HPIVTTNYGKLRGLKTPLPNEILGPVEQYLGIPYALPPTGERR 84

  Fly    70 FAPAKPSSSFNRTLQATTMQPLCPQ------LANTI----YDESSDGSMPRSVSTDEDCLYLNIW 124
            |.|.:|..|:.....||...|:|||      |.|.:    :..:.|..:.......||||||||:
Zfish    85 FQPPEPPMSWPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIY 149

  Fly   125 TP-------------------------ESGMRYGKLPIVVIVTGEEFAYDWPRNRINGLDLAGEG 164
            .|                         |:|:|    |::|.:.|..: .:...|.|:|..||..|
Zfish   150 VPTEDVGANKGDDFTNNEGGENKDIHDENGLR----PVMVYIHGGSY-MEGTGNMIDGSILASYG 209

  Fly   165 -IVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGG 228
             ::||::.||..:.|:||.|:|  ...|||||.|...|||||:.|..||.|:|..:|:.|.|:|.
Zfish   210 NVIVVTLNYRLGVLGFLSTGDQ--AAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGA 272

  Fly   229 APLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVETGQVLVQKLGCQFEEAQRRQLMGCL 293
            :.::|:.....|..:.|..::..|..:.:...|:|.  .:..::|.:|:||...::  ..|:.||
Zfish   273 SCVSLLTLSHYSEDLFQKAIIQSGTALSSWAVNYQP--AKYTRILAEKVGCNMLDS--IDLVECL 333

  Fly   294 RRKSREDLLRAY--ESVYNHGNGSSQLGVILPEG--LPLEQ-RLRNKTLPPVLLGITSNEGAFLQ 353
            :.|:.::|:..|  ::.|:...|....|.::|:.  :.:|| ...|.   .::||:...||....
Zfish   334 QNKNYKELIEQYITQAKYHIAFGPVIDGDVIPDDPQILMEQGEFLNY---DIMLGVNQGEGFKFV 395

  Fly   354 DYWLD-----VAREGQVALHKYINHTLLPNVMRALESVGEESSTQLAAIRWRYFN-GKGEGVSHL 412
            |..:|     .|.:...|:..:::|         |....|...|....|::.|.: ...|.....
Zfish   396 DGIVDSEDGVSANDFDFAVSDFVDH---------LYGYPEGKDTLRETIKFMYTDWADKENPETR 451

  Fly   413 LAGMQRLLSESLYELPYSRILEL--LNGTTSYAYVFDHSHSMDMRGRRNLFGGASHSSDLPL--- 472
            ...:..|.::..:..|.....:|  ..|:.:|.|.|.|....:|:..   :..::|..::|.
Zfish   452 RKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPS---WSDSAHGDEVPYVFG 513

  Fly   473 --LLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNPT-------------PGRIYD-GWL 521
              :|||:   .:....||..:..|...:...:.||.|.|:|.             |.|..: .|.
Zfish   514 IPMLGPT---DLFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAWS 575

  Fly   522 PYNKENPFVYSLG 534
            .||.::.....:|
Zfish   576 KYNPKDQLYLHIG 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	149/579 (26%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	146/575 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810