DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12869 and Ces2h

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	145/560 - (25%)
Similarity:	226/560 - (40%)	Gaps:	138/560 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LSPYISAQQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIPYAQAPINELRFAPAKPSSSFNRTLQ 84
            |||   .:.||    .|.::|..:...|....|::|||||:|:.||..|||||.:....::....
  Rat    29 LSP---IRTTH----TGQILGSLIHMKGLDVGVHSFLGIPFAKPPIGPLRFAPPEAPEPWSGVRD 86

  Fly    85 ATTMQPLCPQ---LANTIYDESSDGSMPRSVSTDEDCLYLNIWTPESGMRYGKLPIVV------I 140
            .|:...:|.|   ..|....:....::| .:...||||||||:||........||::|      :
  Rat    87 GTSHPAMCLQDITAMNMQAFKLLKLTLP-LIPMSEDCLYLNIYTPNHAHEGSNLPVMVWIHGGAL 150

  Fly   141 VTGEEFAYDWPRNRINGLDLAG-EGIVVVSVQYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRW 204
            |.|....||       |..||. |.:|||::|||..:.|:.|.|:||..  ||:|..|...||.|
  Rat   151 VIGMASLYD-------GSMLAAMENVVVVTIQYRLGVLGFFSTGDQHAR--GNWGYLDQVAALHW 206

  Fly   205 IRRNADAFGGNPDHITLLGHGSGGAPLALVATLEDSSQVKQLVLMSPGPIMRALGQNHQKWIVET 269
            :::|...||||||.:|:.|..:||..:        ||.|       ..|:.|.|....   |:|:
  Rat   207 VQQNIAHFGGNPDRVTIFGESAGGTSV--------SSHV-------VSPMSRGLFHGA---IMES 253

  Fly   270 GQVLVQKL----------------GCQFEEAQRRQLMGCLRRKSREDLL---RAYESVYNHGNGS 315
            |..|:..|                ||  |:...:.|:.|||.||.|:::   :|:..:    :|.
  Rat   254 GVALMSSLISVSSDVVYRTVANLSGC--EQVDSKALVNCLRGKSEEEIMSINKAFRII----SGI 312

  Fly   316 SQLGVILPEGLPLEQRLRNKTLP-PVLLGITSNEGAFLQDYWLDVAREGQVALHKYINHTLLPNV 379
            .. |:.||.. |.|........| |.::|:.::|..     |                  ::|:.
  Rat   313 VD-GIFLPRH-PKELLASADFHPIPSIIGVNNDEYG-----W------------------IIPSS 352

  Fly   380 MRALES--------VGEESSTQLAAIRW---------RYFNGKGEGVSHLLAGMQRLLSESLYEL 427
            |...:|        |......::|.:.|         ..:.|..|....|....:.::.:..:.:
  Rat   353 MTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMGDSEDPQFLQVQFKEMMEDFTFVI 417

  Fly   428 PYSRILELLNGTTS-YAYVFDHSHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIARRRFSG-- 489
            |..::......... |.|.|.|..|. .:..:.....|.|..::..:.          |.|.|
  Rat   418 PALQVAHFQRSNAPVYFYEFQHRPSF-FKDSKPPHVKADHGDEILFIF----------RSFWGGT 471

  Fly   490 ------EEEQLCRKIRGAFANFIKNGNPTPGRIYDGWLPY 523
                  |||.|.|::...:|||.:.|||..    :| |||
  Rat   472 QVDLTEEEELLSRRMMKYWANFARQGNPNS----EG-LPY 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	142/553 (26%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	144/559 (26%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	41/111 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920