DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12869 and Ces2h

DIOPT Version :9

Sequence 1:	NP_001369085.1	Gene:	CG12869 / 36616	FlyBaseID:	FBgn0033943	Length:	839	Species:	Drosophila melanogaster
Sequence 2:	NP_001258974.1	Gene:	Ces2h / 436059	MGIID:	3648740	Length:	558	Species:	Mus musculus

Alignment Length:	602	Identity:	151/602 - (25%)
Similarity:	254/602 - (42%)	Gaps:	138/602 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LRIQQI-LRL------LPILIHLSPYISA---QQTHIKLEQGDLIGLKVFPDGTRGAVYAFLGIP 59
            :|::|| .||      |.:|:.:....|.   :.||.....|.||.:|....|    |::|||||
Mouse     1 MRLEQIHARLTTATCGLLLLLRVQGQDSTSPIRTTHTGQILGSLIHMKDLDVG----VHSFLGIP 61

  Fly    60 YAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQ------------LANTIYDESSDGSMPRSV 112
            :|:.|:..|||||.:|...:......|:...:|.|            |..|:      ...|.|
Mouse    62 FAKPPVGPLRFAPPEPPEPWGGVRDGTSHPAMCLQDITAMNMQAFKLLKLTL------PPFPMS- 119

  Fly   113 STDEDCLYLNIWTPESGMRYGKLPIVV------IVTGEEFAYDWPRNRINGLDLAG-EGIVVVSV 170
               ||||||||:.|:.......||::|      :|.|....||       |..||. |.:|||::
Mouse   120 ---EDCLYLNIYAPDHAHEGSNLPVMVWIHGGSLVIGMASMYD-------GSMLAAMENVVVVTI 174

  Fly   171 QYRNNIYGWLSLGEQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAPLALVA 235
            |||..:.|:.|.|::...  ||:|..|...||||:::|...||||||.:|:.|..:||
Mouse   175 QYRLGVLGFFSTGDERAR--GNWGYLDQVAALRWLQQNIAYFGGNPDRVTIFGTSAGG------- 230

  Fly   236 TLEDSSQVKQLVL--MSPGPIMRALGQNHQKWIVETGQVLVQKL----------------GCQFE 282
                 :.|..||:  ||.|....|        |:|:|..|:..|                ||  |
Mouse   231 -----TSVSSLVVSPMSQGLFRGA--------IMESGVALISSLISVSSDVVYQTVANLSGC--E 280

  Fly   283 EAQRRQLMGCLRRKSREDLL---RAYESVYNHGNGSSQLGVILPEGLPLEQRLRNKTLP-PVLLG 343
            :.....|:.|||.||.|:::   :|::.:....:     |:.||.. |.|........| |.::|
Mouse   281 QVDSEALVNCLRGKSEEEIMAINKAFKIIPGIVD-----GIFLPRH-PQELMASADFHPVPSIIG 339

  Fly   344 ITSNEGAFLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGEESSTQL------AAIRWRYF 402
            :.::|..     |:..:....:...|.::..:       ::::.:..:||:      :.:....:
Mouse   340 VNNDEYG-----WIIPSSMSMIDSKKGMDRQM-------VQAILQRRATQMMWPPEVSDLLMEEY 392

  Fly   403 NGKGEGVSHLLAGMQRLLSESLYELPYSRILELLNGTTSYA----YVFDHSHSMDMRGRRNLFGG 463
            .|..|....|....:.::.:..:.:|   .|::.....|:|    |.|.|..|. .:..:.....
Mouse   393 MGDNEDPQFLQVQFKEMMKDFTFVIP---ALQVAQFQRSHAPVFFYEFQHRPSF-FKDSKPSHVK 453

  Fly   464 ASHSSDLPLLLGPSLFQQIARRRFSGEEEQLCRKIRGAFANFIKNGNP-TPGRIYDGWLPYNKEN 527
            |.|..::..:.  ..|....:..|:.|||.|.|::...:|||.:..|| :.|..|  |..::::.
Mouse   454 ADHGDEILFIF--RSFWGGTQVDFTEEEELLSRRMMKYWANFARQRNPNSEGLPY--WPMFDQDE 514

  Fly   528 PFVY-----SLGEQAKT 539
            .::.     ::|...||
Mouse   515 QYLQLDTQPAVGRALKT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	143/570 (25%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:278561	143/573 (25%)
Ces2h	NP_001258974.1	Aes	<127..>230	CDD:223730	39/111 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233524at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010